8AEU

Structure of hMDM2 in complex with Nutlin-3a-aa

Summary for 8AEU

Entry DOI	10.2210/pdb8aeu/pdb
Descriptor	E3 ubiquitin-protein ligase Mdm2, BETA-MERCAPTOETHANOL, 4-[[(4~{S},5~{R})-4,5-bis(4-chlorophenyl)-2-(4-methoxy-2-propan-2-yloxy-phenyl)-4,5-dihydroimidazol-1-yl]carbonyl]-3-methylidene-piperazin-2-one, ... (4 entities in total)
Functional Keywords	biological activity, drug design, inhibitors, protein-protein interactions, ligase
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	12071.01
Authors	Labuzek, B.,Golik, P.,Magiera-Mularz, K.,Berg, T. (deposition date: 2022-07-13, release date: 2023-01-18, Last modification date: 2024-02-07)
Primary citation	Nietzold, F.,Rubner, S.,Labuzek, B.,Golik, P.,Surmiak, E.,Del Corte, X.,Kitel, R.,Protzel, C.,Reppich-Sacher, R.,Stichel, J.,Magiera-Mularz, K.,Holak, T.A.,Berg, T. Nutlin-3a-aa: Improving the Bioactivity of a p53/MDM2 Interaction Inhibitor by Introducing a Solvent-Exposed Methylene Group. Chembiochem, 24:e202300006-e202300006, 2023 Cited by PubMed: 36602436 DOI: 10.1002/cbic.202300006 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation