5OC8

HDM2 (17-111, WILD TYPE) COMPLEXED WITH NVP-HDM201 AT 1.56A

Summary for 5OC8

• Entry DOI: 10.2210/pdb5oc8/pdb
• Related: 5LN2
• Descriptor: E3 ubiquitin-protein ligase Mdm2, (4~{S})-5-(5-chloranyl-1-methyl-2-oxidanylidene-pyridin-3-yl)-4-(4-chlorophenyl)-2-(2,4-dimethoxypyrimidin-5-yl)-3-propan-2-yl-4~{H}-pyrrolo[3,4-d]imidazol-6-one, CHLORIDE ION, ... (4 entities in total)
• Functional Keywords: ppi with p53, inhibitor complex, cell cycle, ligase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 11746.92

Authors

Kallen, J. (deposition date: 2017-06-29, release date: 2018-08-22, Last modification date: 2024-01-17)

• Primary citation: Jeay, S.,Ferretti, S.,Holzer, P.,Fuchs, J.,Chapeau, E.A.,Wartmann, M.,Sterker, D.,Romanet, V.,Murakami, M.,Kerr, G.,Durand, E.Y.,Gaulis, S.,Cortes-Cros, M.,Ruetz, S.,Stachyra, T.M.,Kallen, J.,Furet, P.,Wurthner, J.,Guerreiro, N.,Halilovic, E.,Jullion, A.,Kauffmann, A.,Kuriakose, E.,Wiesmann, M.,Jensen, M.R.,Hofmann, F.,Sellers, W.R.; Dose and Schedule Determine Distinct Molecular Mechanisms Underlying the Efficacy of the p53-MDM2 Inhibitor HDM201.; Cancer Res., 78:6257-6267, 2018; PubMed: 30135191; DOI: 10.1158/0008-5472.CAN-18-0338

Experimental method

X-RAY DIFFRACTION (1.56 Å)