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1NUK
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1nuk
CRYSTAL STRUCTURE OF THE LIGAND-BINDING DOMAIN OF THE EPHB2 RECEPTOR TYROSINE KINASE
Descriptor:PROTEIN (TYROSINE-PROTEIN KINASE RECEPTOR EPH) (2.7.1.112)
Authors:Himanen, J.-P., Henkemeyer, M., Nikolov, D.B.
Deposit date:1998-10-13
Release date:1999-10-13
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Crystal structure of the ligand-binding domain of the receptor tyrosine kinase EphB2.
Nature, 396, 1998
2BBA
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2bba
CRYSTAL STRUCTURE AND THERMODYNAMIC CHARACTERIZATION OF THE EPHB4 RECEPTOR IN COMPLEX WITH AN EPHRIN-B2 ANTAGONIST PEPTIDE REVEALS THE DETERMINANTS FOR RECEPTOR SPECIFICITY.
Descriptor:Ephrin type-B receptor 4 (E.C.2.7.1.112)
Authors:Chrencik, J.E., Kuhn, P., Accelerated Technologies Center for Gene to 3D Structure (ATCG3D)
Deposit date:2005-10-17
Release date:2006-07-18
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Structure and thermodynamic characterization of the EphB4/Ephrin-B2 antagonist peptide complex reveals the determinants for receptor specificity.
Structure, 14, 2006
2LW8
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2lw8
NMR SOLUTION STRUCTURE OF EPH RECEPTOR
Descriptor:Ephrin type-A receptor 4
Authors:Qin, H., Song, J.
Deposit date:2012-07-24
Release date:2013-07-24
Method:SOLUTION NMR
Cite:NMR solution structure of Eph receptor
To be Published
2QBX
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2qbx
EPHB2/SNEW ANTAGONISTIC PEPTIDE COMPLEX
Descriptor:Ephrin type-B receptor 2 (E.C.2.7.10.1), antagonistic peptide
Authors:Chrencik, J.E., Brooun, A., Recht, M.I., Nicola, G., Pasquale, E.B., Kuhn, P., Accelerated Technologies Center for Gene to 3D Structure (ATCG3D)
Deposit date:2007-06-18
Release date:2007-11-06
Modification date:2009-09-08
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Three-dimensional structure of the EphB2 receptor in complex with an antagonistic peptide reveals a novel mode of inhibition.
J.Biol.Chem., 282, 2007
2WO1
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2wo1
CRYSTAL STRUCTURE OF THE EPHA4 LIGAND BINDING DOMAIN
Descriptor:EPHRIN TYPE-A RECEPTOR (E.C.2.7.10.1)
Authors:Bowden, T.A., Aricescu, A.R., Nettleship, J.E., Siebold, C., Rahman-Huq, N., Owens, R.J., Stuart, D.I., Jones, E.Y.
Deposit date:2009-07-21
Release date:2009-10-27
Modification date:2011-11-23
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Structural Plasticity of Eph-Receptor A4 Facilitates Cross-Class Ephrin Signalling
Structure, 17, 2009
3C8X
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3c8x
CRYSTAL STRUCTURE OF THE LIGAND BINDING DOMAIN OF HUMAN EPHRIN A2 (EPHA2) RECEPTOR PROTEIN KINASE
Descriptor:Ephrin type-A receptor 2 (E.C.2.7.10.1)
Authors:Walker, J.R., Yermekbayeva, L., Seitova, A., Butler-Cole, C., Bountra, C., Weigelt, J., Arrowsmith, C.H., Edwards, A.M., Bochkarev, A., Dhe-Paganon, S., Structural Genomics Consortium (SGC)
Deposit date:2008-02-14
Release date:2008-03-25
Modification date:2010-06-30
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Architecture of Eph receptor clusters.
Proc.Natl.Acad.Sci.USA, 107, 2010
3CKH
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3ckh
CRYSTAL STRUCTURE OF EPH A4 RECEPTOR
Descriptor:Ephrin type-A receptor 4 (E.C.2.7.10.1)
Authors:Shi, J.H., Song, J.X.
Deposit date:2008-03-15
Release date:2008-09-23
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal Structure and NMR Binding Reveal That Two Small Molecule Antagonists Target the High Affinity Ephrin-binding Channel of the EphA4 Receptor
J.Biol.Chem., 283, 2008
3CZU
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3czu
CRYSTAL STRUCTURE OF THE HUMAN EPHRIN A2- EPHRIN A1 COMPLEX
Descriptor:Ephrin type-A receptor 2 (E.C.2.7.10.1), Ephrin-A1
Authors:Walker, J.R., Yermekbayeva, L., Seitova, A., Butler-Cole, C., Bountra, C., Wikstrom, M., Arrowsmith, C.H., Edwards, A.M., Bochkarev, A., Dhe-Paganon, S., Structural Genomics Consortium (SGC)
Deposit date:2008-04-30
Release date:2008-08-12
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Architecture of Eph receptor clusters.
Proc.Natl.Acad.Sci.USA, 107, 2010
3ETP
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3etp
THE CRYSTAL STRUCTURE OF THE LIGAND-BINDING DOMAIN OF THE EPHB2 RECEPTOR AT 2.0 A RESOLUTION
Descriptor:Ephrin type-B receptor 2 (E.C.2.7.10.1)
Authors:Goldgur, Y., Paavilainen, S., Nikolov, D.B, Himanen, J.P.
Deposit date:2008-10-08
Release date:2008-10-21
Modification date:2009-06-09
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure of the ligand-binding domain of the EphB2 receptor at 2 A resolution.
Acta Crystallogr.,Sect.F, 65, 2009
3HPN
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3hpn
LIGAND RECOGNITION BY A-CLASS EPH RECEPTORS: CRYSTAL STRUCTURES OF THE EPHA2 LIGAND-BINDING DOMAIN AND THE EPHA2/EPHRIN-A1 COMPLEX
Descriptor:Ephrin type-A receptor 2 (E.C.2.7.10.1)
Authors:Himanen, J.P., Goldgur, Y., Miao, H., Myshkin, E., Guo, H., Buck, M., Nguyen, M., Rajashankar, K.R., Wang, B., Nikolov, D.B.
Deposit date:2009-06-04
Release date:2009-06-30
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (2.52 Å)
Cite:Ligand recognition by A-class Eph receptors: crystal structures of the EphA2 ligand-binding domain and the EphA2/ephrin-A1 complex.
Embo Rep., 10, 2009
3NRU
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3nru
LIGAND BINDING DOMAIN OF EPHA7
Descriptor:Ephrin receptor (E.C.2.7.10.1)
Authors:Walker, J.R., Yermekbayeva, L., Seitova, A., Kania, J., Bountra, C., Weigelt, J., Arrowsmith, C.H., Edwards, A.M., Bochkarev, A., Dhe-Paganon, S.
Deposit date:2010-06-30
Release date:2010-12-08
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Ephrin A7 ligand binding domain
To be Published
3P1I
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3p1i
LIGAND BINDING DOMAIN OF HUMAN EPHRIN TYPE-B RECEPTOR 3
Descriptor:Ephrin type-B receptor 3 (E.C.2.7.10.1)
Authors:Walker, J.R., Yermekbayeva, L., Seitova, A., Kania, J., Bountra, C., Weigelt, J., Arrowsmith, C.H., Edwards, A.M., Bochkarev, A., Dhe-Paganon, S., Structural Genomics Consortium (SGC)
Deposit date:2010-09-30
Release date:2011-01-19
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Ligand Binding Domain of Human Ephb3
To be Published
3SKJ
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3skj
STRUCTURAL AND FUNCTIONAL CHARACTERIZATION OF AN AGONISTIC ANTI-HUMAN EPHA2 MONOCLONAL ANTIBODY
Descriptor:Antibody, light chain, Antibody, heavy chain, Ephrin type-A receptor 2 (E.C.2.7.10.1)
Authors:Oganesyan, V.Y., Wu, H., Dall'Acqua, W.F.
Deposit date:2011-06-22
Release date:2011-08-31
Modification date:2012-08-29
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural and functional characterization of an agonistic anti-human EphA2 monoclonal antibody.
J.Mol.Biol., 413, 2011
4ET7
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4et7
CRYSTAL STRUCTURE OF EPH RECEPTOR 5
Descriptor:Ephrin type-A receptor 5 (E.C.2.7.10.1)
Authors:Shi, J.H., Zhu, W.L., Song, J.X.
Deposit date:2012-04-24
Release date:2013-05-22
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Crystal structure of Eph receptor 5
To be Published
4W4Z
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4w4z
STRUCTURE OF THE EPHA4 LBD IN COMPLEX WITH PEPTIDE
Descriptor:Ephrin type-A receptor 4 (E.C.2.7.10.1), APY-bAla8.am peptide
Authors:Lechtenberg, B.C., Mace, P.D., Riedl, S.J.
Deposit date:2014-08-15
Release date:2014-10-08
Method:X-RAY DIFFRACTION (2.41 Å)
Cite:Development and Structural Analysis of a Nanomolar Cyclic Peptide Antagonist for the EphA4 Receptor.
Acs Chem.Biol., 2014
4W50
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4w50
STRUCTURE OF THE EPHA4 LBD IN COMPLEX WITH PEPTIDE
Descriptor:Ephrin type-A receptor 4 (E.C.2.7.10.1), APY peptide
Authors:Lechtenberg, B.C., Mace, P.D., Riedl, S.J.
Deposit date:2014-08-16
Release date:2014-10-08
Method:X-RAY DIFFRACTION (2.42 Å)
Cite:Development and Structural Analysis of a Nanomolar Cyclic Peptide Antagonist for the EphA4 Receptor.
Acs Chem.Biol., 2014
1KGY
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1kgy
CRYSTAL STRUCTURE OF THE EPHB2-EPHRINB2 COMPLEX
Descriptor:EPHRIN TYPE-B RECEPTOR 2 (E.C.2.7.1.112), EPHRIN-B2
Authors:Himanen, J-P., Rajashankar, K.R., Lackmann, M., Cowan, C.A., Henkemeyer, M., Nikolov, D.B.
Deposit date:2001-11-28
Release date:2002-05-28
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Crystal structure of an Eph receptor-ephrin complex.
Nature, 414, 2001
2HLE
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2hle
STRUCTURAL AND BIOPHYSICAL CHARACTERIZATION OF THE EPHB4-EPHRINB2 PROTEIN PROTEIN INTERACTION AND RECEPTOR SPECIFICITY.
Descriptor:Ephrin type-B receptor 4 (E.C.2.7.10.1), Ephrin-B2
Authors:Chrencik, J.E., Brooun, A., Kuhn, P., Accelerated Technologies Center for Gene to 3D Structure (ATCG3D)
Deposit date:2006-07-06
Release date:2006-08-22
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Structural and Biophysical Characterization of the EphB4-EphrinB2 Protein-Protein Interaction and Receptor Specificity.
J.Biol.Chem., 281, 2006
2WO2
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2wo2
CRYSTAL STRUCTURE OF THE EPHA4-EPHRINB2 COMPLEX
Descriptor:EPHRIN TYPE-A RECEPTOR (E.C.2.7.10.1), EPHRIN-B2
Authors:Bowden, T.A., Aricescu, A.R., Nettleship, J.E., Siebold, C., Rahman-Huq, N., Owens, R.J., Stuart, D.I., Jones, E.Y.
Deposit date:2009-07-21
Release date:2009-10-27
Modification date:2011-11-09
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Structural Plasticity of Eph-Receptor A4 Facilitates Cross-Class Ephrin Signalling
Structure, 17, 2009
2WO3
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2wo3
CRYSTAL STRUCTURE OF THE EPHA4-EPHRINA2 COMPLEX
Descriptor:EPHRIN TYPE-A RECEPTOR (E.C.2.7.10.1), EPHRIN-A2
Authors:Bowden, T.A., Aricescu, A.R., Nettleship, J.E., Siebold, C., Rahman-Huq, N., Owens, R.J., Stuart, D.I., Jones, E.Y.
Deposit date:2009-07-21
Release date:2009-10-27
Modification date:2011-11-23
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Structural Plasticity of Eph-Receptor A4 Facilitates Cross-Class Ephrin Signalling
Structure, 17, 2009
3GXU
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3gxu
CRYSTAL STRUCTURE OF EPH RECEPTOR AND EPHRIN COMPLEX
Descriptor:Ephrin type-A receptor 4, Ephrin-B2
Authors:Qin, H.N., Song, J.X.
Deposit date:2009-04-03
Release date:2009-10-27
Modification date:2009-11-10
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural characterization of the EphA4-ephrin-B2 complex reveals new features enabling Eph-ephrin binding promiscuity
J.Biol.Chem., 2009
3HEI
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3hei
LIGAND RECOGNITION BY A-CLASS EPH RECEPTORS: CRYSTAL STRUCTURES OF THE EPHA2 LIGAND-BINDING DOMAIN AND THE EPHA2/EPHRIN-A1 COMPLEX
Descriptor:Ephrin type-A receptor 2 (E.C.2.7.10.1), Ephrin-A1
Authors:Himanen, J.P., Goldgur, Y., Miao, H., Myshkin, E., Guo, H., Buck, M., Nguyen, M., Rajashankar, K.R., Wang, B., Nikolov, D.B.
Deposit date:2009-05-08
Release date:2009-06-30
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Ligand recognition by A-class Eph receptors: crystal structures of the EphA2 ligand-binding domain and the EphA2/ephrin-A1 complex.
Embo Rep., 10, 2009
3MBW
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3mbw
CRYSTAL STRUCTURE OF THE HUMAN EPHRIN A2 LBD AND CRD DOMAINS IN COMPLEX WITH EPHRIN A1
Descriptor:Crystal structure of the human ephrin A2 LBD and CRD domains complex with ephrin A1
Authors:Walker, J.R., Yermekbayeva, L., Seitova, A., Butler-Cole, C., Bountra, C., Weigelt, J., Arrowsmith, C.H., Edwards, A.M., Bochkarev, A., Dhe-Paganon, S., Structural Genomics Consortium (SGC)
Deposit date:2010-03-26
Release date:2010-06-09
Modification date:2010-06-30
Method:X-RAY DIFFRACTION (2.81 Å)
Cite:Architecture of Eph receptor clusters.
Proc.Natl.Acad.Sci.USA, 107, 2010
4L0P
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4l0p
STRUCTURE OF THE HUMAN EPHA3 RECEPTOR LIGAND BINDING DOMAIN COMPLEXED WITH EPHRIN-A5
Descriptor:Ephrin type-A receptor 3, Ephrin-A5
Authors:Forse, G.J., Kolatkar, A.R., Kuhn, P.
Deposit date:2013-05-31
Release date:2014-06-11
Method:X-RAY DIFFRACTION (2.26 Å)
Cite:Cancer-specific Somatic Mutations Result in Structural and Thermodynamic Changes in the EphA3 Receptor
To be Published
1SHW
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1shw
EPHB2 / EPHRINA5 COMPLEX STRUCTURE
Descriptor:Ephrin-A5/Ephrin type-B receptor 2
Authors:Himanen, J.P., Chumley, M.J., Lackmann, M., Li, C., Barton, W.A., Jeffrey, P.D., Vearing, C., Geleick, D., Feldheim, D.A., Boyd, A.W.
Deposit date:2004-02-26
Release date:2004-05-18
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Repelling class discrimination: ephrin-A5 binds to and activates EphB2 receptor signaling
Nat.Neurosci., 7, 2004
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