5JR2
Crystal structure of the EphA4 LBD in complex with APYd3 peptide inhibitor
Summary for 5JR2
Entry DOI | 10.2210/pdb5jr2/pdb |
Descriptor | Ephrin type-A receptor 4, APYd3 peptide, HEXANE-1,6-DIOL, ... (5 entities in total) |
Functional Keywords | receptor tyrosine kinase, peptide inhibitor, ephrin, als, transferase-inhibitor complex, transferase/inhibitor |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 8 |
Total formula weight | 89020.84 |
Authors | Lechtenberg, B.C.,Olson, E.J.,Pasquale, E.B.,Dawson, P.E.,Riedl, S.J. (deposition date: 2016-05-05, release date: 2016-07-06, Last modification date: 2023-09-27) |
Primary citation | Olson, E.J.,Lechtenberg, B.C.,Zhao, C.,Rubio de la Torre, E.,Lamberto, I.,Riedl, S.J.,Dawson, P.E.,Pasquale, E.B. Modifications of a Nanomolar Cyclic Peptide Antagonist for the EphA4 Receptor To Achieve High Plasma Stability. Acs Med.Chem.Lett., 7:841-846, 2016 Cited by PubMed: 27660688DOI: 10.1021/acsmedchemlett.6b00132 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.75 Å) |
Structure validation
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