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1F16
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1f16
SOLUTION STRUCTURE OF A PRO-APOPTOTIC PROTEIN BAX
Descriptor:SOLUTION STRUCTURE OF A PRO-APOPTOTIC PROTEIN BAX
Authors:Suzuki, M., Youle, R.J., Tjandra, N.
Deposit date:2000-05-18
Release date:2000-11-22
Modification date:2009-02-24
Method:SOLUTION NMR
Cite:Structure of Bax: coregulation of dimer formation and intracellular localization.
Cell(Cambridge,Mass.), 103, 2000
1K3K
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1k3k
SOLUTION STRUCTURE OF A BCL-2 HOMOLOG FROM KAPOSI'S SARCOMA VIRUS
Descriptor:functional anti-apoptotic factor vBCL-2 homolog
Authors:Huang, Q., Petros, A.M., Virgin, H.W., Fesik, S.W., Olejniczak, E.T.
Deposit date:2001-10-03
Release date:2002-04-10
Modification date:2009-02-24
Method:SOLUTION NMR
Cite:Solution structure of a Bcl-2 homolog from Kaposi sarcoma virus.
Proc.Natl.Acad.Sci.USA, 99, 2002
1Q59
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1q59
SOLUTION STRUCTURE OF THE BHRF1 PROTEIN FROM EPSTEIN-BARR VIRUS, A HOMOLOG OF HUMAN BCL-2
Descriptor:Early antigen protein R
Authors:Huang, Q., Petros, A.M., Virgin, H.W., Fesik, S.W., Olejniczak, E.T.
Deposit date:2003-08-06
Release date:2003-09-23
Modification date:2009-02-24
Method:SOLUTION NMR
Cite:Solution Structure of the BHRF1 Protein From Epstein-Barr Virus, a Homolog of Human Bcl-2
J.Mol.Biol., 332, 2003
1WSX
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1wsx
SOLUTION STRUCTURE OF MCL-1
Descriptor:myeloid cell leukemia sequence 1
Authors:Day, C.L., Chen, L., Richardson, S.J., Harrison, P.J., Huang, D.C., Hinds, M.G.
Deposit date:2004-11-12
Release date:2004-11-23
Modification date:2009-02-24
Method:SOLUTION NMR
Cite:Solution Structure of Prosurvival Mcl-1 and Characterization of Its Binding by Proapoptotic BH3-only Ligands
J.Biol.Chem., 280, 2005
2IMS
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2ims
THE X-RAY STRUCTURE OF A BAK HOMODIMER REVEALS AN INHIBITORY ZINC BINDING SITE
Descriptor:Apoptosis regulator BAK
Authors:Moldoveanu, T., Liu, Q., Tocilj, A., Watson, M., Shore, G.C., Gehring, K.B.
Deposit date:2006-10-04
Release date:2006-12-26
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (1.48 Å)
Cite:The X-Ray Structure of a BAK Homodimer Reveals an Inhibitory Zinc Binding Site
Mol.Cell, 24, 2006
2IMT
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2imt
THE X-RAY STRUCTURE OF A BAK HOMODIMER REVEALS AN INHIBITORY ZINC BINDING SITE
Descriptor:Apoptosis regulator BAK
Authors:Moldoveanu, T., Liu, Q., Tocilj, A., Watson, M., Shore, G.C., Gehring, K.B.
Deposit date:2006-10-04
Release date:2007-01-23
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (1.49 Å)
Cite:The X-ray structure of a BAK homodimer reveals an inhibitory zinc binding site.
Mol.Cell, 24, 2006
2JCN
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2jcn
THE CRYSTAL STRUCTURE OF BAK1 - A MITOCHONDRIAL APOPTOSIS REGULATOR
Descriptor:BCL-2 HOMOLOGOUS ANTAGONIST/KILLER
Authors:Moche, M., Stenmark, P., Arrowsmith, C., Berglund, H., Busam, R., Collins, R., Edwards, A., Ericsson, U.B., Flodin, S., Flores, A., Graslund, S., Hammarstrom, M., Hallberg, B.M., Holmberg Schiavone, L., Johansson, I., Karlberg, T., Kosinska, U., Kotenyova, T., Lundgren, S., Nilsson, M.E., Nyman, T., Ogg, D., Persson, C., Sagemark, J., Sundstrom, M., Uppenberg, J., Upsten, M., Thorsell, A.G., Van Den Berg, S., Weigelt, J., Nordlund, P., Structural Genomics Consortium (Sgc)
Deposit date:2006-12-27
Release date:2007-01-04
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:The Crystal Structure of Bak1 - an Apoptosis Trigger in the Mitochondrial Outer Membrane
To be Published
2KUA
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2kua
SOLUTION STRUCTURE OF A DIVERGENT BCL-2 PROTEIN
Descriptor:Bcl-2-like protein 10
Authors:Rautureau, G.J., Day, C.L., Hinds, M.G.
Deposit date:2010-02-16
Release date:2010-03-23
Modification date:2010-05-19
Method:SOLUTION NMR
Cite:The structure of Boo/Diva reveals a divergent Bcl-2 protein.
Proteins, 78, 2010
2LR1
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2lr1
STRUCTURAL MECHANISM FOR BAX INHIBITION BY CYTOMEGALOVIRUS PROTEIN VMIA
Descriptor:Apoptosis regulator BAX, Immediate early glycoprotein
Authors:Ma, J.
Deposit date:2012-03-20
Release date:2012-12-05
Modification date:2013-01-16
Method:SOLUTION NMR
Cite:Structural mechanism of Bax inhibition by cytomegalovirus protein vMIA.
Proc.Natl.Acad.Sci.USA, 109, 2012
2MHS
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2mhs
NMR STRUCTURE OF HUMAN MCL-1
Descriptor:Induced myeloid leukemia cell differentiation protein Mcl-1
Authors:Liu, G., Poppe, L., Aoki, K., Yamane, H., Lewis, J., Szyperski, T.
Deposit date:2013-12-04
Release date:2014-05-14
Method:SOLUTION NMR
Cite:High-Quality NMR Structure of Human Anti-Apoptotic Protein Domain Mcl-1(171-327) for Cancer Drug Design.
Plos One, 9, 2014
2ROC
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2roc
SOLUTION STRUCTURE OF MCL-1 COMPLEXED WITH PUMA
Descriptor:Induced myeloid leukemia cell differentiation protein Mcl-1 homolog, Bcl-2-binding component 3
Authors:Day, C.L., Smits, C., Fan, F.C., Lee, E.F., Fairlie, W.D., Hinds, M.G.
Deposit date:2008-03-17
Release date:2008-07-08
Modification date:2009-02-24
Method:SOLUTION NMR
Cite:Structure of the BH3 Domains from the p53-Inducible BH3-Only Proteins Noxa and Puma in Complex with Mcl-1
J.Mol.Biol., 380, 2008
2ROD
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2rod
SOLUTION STRUCTURE OF MCL-1 COMPLEXED WITH NOXAA
Descriptor:Induced myeloid leukemia cell differentiation protein Mcl-1 homolog, Noxa
Authors:Day, C.L., Smits, C., Fan, F.C., Lee, E.F., Fairlie, W.D., Hinds, M.G.
Deposit date:2008-03-17
Release date:2008-07-08
Modification date:2009-02-24
Method:SOLUTION NMR
Cite:Structure of the BH3 Domains from the p53-Inducible BH3-Only Proteins Noxa and Puma in Complex with Mcl-1
J.Mol.Biol., 380, 2008
2VOF
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2vof
STRUCTURE OF MOUSE A1 BOUND TO THE PUMA BH3-DOMAIN
Descriptor:BCL-2-RELATED PROTEIN A1, BCL-2-BINDING COMPONENT 3
Authors:Smits, C., Czabotar, P.E., Hinds, M.G., Day, C.L.
Deposit date:2008-02-17
Release date:2008-03-04
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural Plasticity Underpins Promiscuous Binding of the Prosurvival Protein A1.
Structure, 16, 2008
2VOH
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2voh
STRUCTURE OF MOUSE A1 BOUND TO THE BAK BH3-DOMAIN
Descriptor:BCL-2-RELATED PROTEIN A1, BCL-2 HOMOLOGOUS ANTAGONIST/KILLER
Authors:Smits, C., Czabotar, P.E., Hinds, M.G., Day, C.L.
Deposit date:2008-02-17
Release date:2008-03-04
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural Plasticity Underpins Promiscuous Binding of the Prosurvival Protein A1.
Structure, 16, 2008
2XPX
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2xpx
CRYSTAL STRUCTURE OF BHRF1:BAK BH3 COMPLEX
Descriptor:APOPTOSIS REGULATOR BHRF1, BCL-2 HOMOLOGOUS ANTAGONIST/KILLER
Authors:Kvansakul, M., Huang, D.C.S., Colman, P.M.
Deposit date:2010-08-31
Release date:2011-01-26
Modification date:2011-12-28
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Structural Basis for Apoptosis Inhibition by Epstein-Barr Virus Bhrf1.
Plos Pathog., 6, 2010
2YV6
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2yv6
CRYSTAL STRUCTURE OF HUMAN BCL-2 FAMILY PROTEIN BAK
Descriptor:Bcl-2 homologous antagonist/killer
Authors:Wang, H., Kishishita, S., Murayama, K., Takemoto, C., Terada, T., Shirouzu, M., RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2007-04-09
Release date:2008-04-15
Modification date:2010-02-02
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Novel dimerization mode of the human Bcl-2 family protein Bak, a mitochondrial apoptosis regulator.
J.Struct.Biol., 166, 2009
3I1H
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3i1h
CRYSTAL STRUCTURE OF HUMAN BFL-1 IN COMPLEX WITH BAK BH3 PEPTIDE
Descriptor:Protein BFL-1, Apoptosis regulator BAK
Authors:Guan, R., Xiao, R., Zhao, L., Acton, T., White, E., Gelinas, C., Montelione, G.T., Northeast Structural Genomics Consortium (NESG)
Deposit date:2009-06-26
Release date:2009-07-14
Modification date:2014-11-12
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:crystal structure of human BFL-1 in complex with BAK BH3 peptide
To be Published
3MK8
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3mk8
THE MCL-1 BH3 HELIX IS AN EXCLUSIVE MCL-1 INHIBITOR AND APOPTOSIS SENSITIZER
Descriptor:Induced myeloid leukemia cell differentiation protein Mcl-1/MCL-1 stapled BH3 domain complex
Authors:Stewart, M., Fire, E., Keating, A.E., Walensky, L.D.
Deposit date:2010-04-14
Release date:2010-06-23
Modification date:2010-08-04
Method:X-RAY DIFFRACTION (2.321 Å)
Cite:The MCL-1 BH3 helix is an exclusive MCL-1 inhibitor and apoptosis sensitizer.
Nat.Chem.Biol., 6, 2010
3PK1
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3pk1
CRYSTAL STRUCTURE OF MCL-1 IN COMPLEX WITH THE BAXBH3 DOMAIN
Descriptor:Induced myeloid leukemia cell differentiation protein Mcl-1, Apoptosis regulator BAX
Authors:Czabotar, P.E., Colman, P.M.
Deposit date:2010-11-11
Release date:2010-12-29
Modification date:2014-01-22
Method:X-RAY DIFFRACTION (2.486 Å)
Cite:Mutation to Bax beyond the BH3 domain disrupts interactions with pro-survival proteins and promotes apoptosis
J.Biol.Chem., 286, 2011
3QBR
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3qbr
BAKBH3 IN COMPLEX WITH SJA
Descriptor:SJCHGC06286 protein, Bcl-2 homologous antagonist/killer
Authors:Lee, E.F., Clarke, O.B., Fairlie, W.D., Colman, P.M., Evangelista, M., Feng, Z., Speed, T.P., Tchoubrieva, E., Strasser, A., Kalinna, B.
Deposit date:2011-01-13
Release date:2011-04-13
Modification date:2013-06-26
Method:X-RAY DIFFRACTION (2.601 Å)
Cite:Discovery and molecular characterization of a Bcl-2-regulated cell death pathway in schistosomes.
Proc.Natl.Acad.Sci.USA, 108, 2011
3WIX
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3wix
CRYSTAL STRUCTURE OF MCL-1 IN COMPLEX WITH COMPOUND 4
Descriptor:Induced myeloid leukemia cell differentiation protein Mcl-1
Authors:Sogabe, S., Igaki, S., Hayano, Y.
Deposit date:2013-09-26
Release date:2013-11-27
Modification date:2014-03-12
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Discovery of potent Mcl-1/Bcl-xL dual inhibitors by using a hybridization strategy based on structural analysis of target proteins.
J.Med.Chem., 56, 2013
3WIY
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3wiy
CRYSTAL STRUCTURE OF MCL-1 IN COMPLEX WITH COMPOUND 10
Descriptor:Induced myeloid leukemia cell differentiation protein Mcl-1
Authors:Sogabe, S., Igaki, S., Hayano, Y.
Deposit date:2013-09-26
Release date:2013-11-27
Modification date:2014-03-12
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Discovery of potent Mcl-1/Bcl-xL dual inhibitors by using a hybridization strategy based on structural analysis of target proteins.
J.Med.Chem., 56, 2013
4BD6
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4bd6
BAX DOMAIN SWAPPED DIMER IN COMPLEX WITH BAXBH3
Descriptor:APOPTOSIS REGULATOR BAX
Authors:Czabotar, P.E., Westphal, D., Adams, J.M., Colman, P.M.
Deposit date:2012-10-05
Release date:2013-02-13
Method:X-RAY DIFFRACTION (2.494 Å)
Cite:Bax Crystal Structures Reveal How Bh3 Domains Activate Bax and Nucleate its Oligomerization to Induce Apoptosis.
Cell(Cambridge,Mass.), 152, 2013
4BD7
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4bd7
BAX DOMAIN SWAPPED DIMER INDUCED BY OCTYLMALTOSIDE
Descriptor:APOPTOSIS REGULATOR BAX
Authors:Czabotar, P.E., Westphal, D., Adams, J.M., Colman, P.M.
Deposit date:2012-10-05
Release date:2013-02-13
Method:X-RAY DIFFRACTION (2.801 Å)
Cite:Bax Crystal Structures Reveal How Bh3 Domains Activate Bax and Nucleate its Oligomerization to Induce Apoptosis.
Cell(Cambridge,Mass.), 152, 2013
4BD8
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4bd8
BAX DOMAIN SWAPPED DIMER INDUCED BY BIMBH3 WITH CHAPS
Descriptor:APOPTOSIS REGULATOR BAX
Authors:Czabotar, P.E., Westphal, D., Adams, J.M., Colman, P.M.
Deposit date:2012-10-05
Release date:2013-02-13
Method:X-RAY DIFFRACTION (2.22 Å)
Cite:Bax Crystal Structures Reveal How Bh3 Domains Activate Bax and Nucleate its Oligomerization to Induce Apoptosis.
Cell(Cambridge,Mass.), 152, 2013
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105212
entries available on 2014-11-26
00:00 UTC / 09:00 JST