2KBW

Solution Structure of human Mcl-1 complexed with human Bid_BH3 peptide

Summary for 2KBW

• Entry DOI: 10.2210/pdb2kbw/pdb
• Related: 1wsx
• Descriptor: Induced myeloid leukemia cell differentiation protein Mcl-1, BH3-interacting domain death agonist (2 entities in total)
• Functional Keywords: mcl-1, bid_bh3, complex, alternative splicing, apoptosis, cytoplasm, developmental protein, differentiation, membrane, mitochondrion, nucleus, phosphoprotein, polymorphism, transmembrane, ubl conjugation
• Biological source: Homo sapiens (human); More
• Cellular location: Membrane; Single-pass membrane protein (Potential): Q07820; Cytoplasm (By similarity). BH3-interacting domain death agonist p15: Mitochondrion membrane (By similarity). BH3-interacting domain death agonist p13: Mitochondrion membrane (By similarity). Isoform 1: Cytoplasm. Isoform 3: Cytoplasm. Isoform 2: Mitochondrion membrane: P55957
• Total number of polymer chains: 2
• Total formula weight: 22449.34

Authors

Liu, Q.,Moldoveanu, T.,Sprules, T.,Matta-Camacho, E.,Mansur-Azzam, N.,Gehring, K. (deposition date: 2008-12-09, release date: 2009-12-15, Last modification date: 2022-03-16)

• Primary citation: Liu, Q.,Moldoveanu, T.,Sprules, T.,Matta-Camacho, E.,Mansur-Azzam, N.,Gehring, K.; Apoptotic regulation by MCL-1 through heterodimerization.; J.Biol.Chem., 285:19615-19624, 2010; PubMed: 20392693; DOI: 10.1074/jbc.M110.105452

Experimental method

SOLUTION NMR