3MK8
The MCL-1 BH3 Helix is an Exclusive MCL-1 Inhibitor and Apoptosis Sensitizer
Summary for 3MK8
| Entry DOI | 10.2210/pdb3mk8/pdb |
| Descriptor | Induced myeloid leukemia cell differentiation protein Mcl-1 (3 entities in total) |
| Functional Keywords | mcl-1, mcl-1 sahb d, staple, sahb, bcl-2 family, apoptosis, anti-apoptotic, apoptosis-apoptosis regulator complex, apoptosis/apoptosis regulator |
| Biological source | Homo sapiens (human) |
| Cellular location | Membrane ; Single-pass membrane protein : Q07820 Q07820 |
| Total number of polymer chains | 2 |
| Total formula weight | 20337.17 |
| Authors | Stewart, M.,Fire, E.,Keating, A.E.,Walensky, L.D. (deposition date: 2010-04-14, release date: 2010-06-23, Last modification date: 2023-11-22) |
| Primary citation | Stewart, M.L.,Fire, E.,Keating, A.E.,Walensky, L.D. The MCL-1 BH3 helix is an exclusive MCL-1 inhibitor and apoptosis sensitizer. Nat.Chem.Biol., 6:595-601, 2010 Cited by PubMed: 20562877DOI: 10.1038/nchembio.391 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.321 Å) |
Structure validation
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