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9INS
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BU of 9ins by Molmil
MONOVALENT CATION BINDING IN CUBIC INSULIN CRYSTALS
Descriptor: INSULIN (CHAIN A), INSULIN (CHAIN B)
Authors:Badger, J, Dodson, G.G.
Deposit date:1991-10-23
Release date:1991-11-07
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Monovalent cation binding to cubic insulin crystals
Biophys.J., 61, 1992
8Z4B
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BU of 8z4b by Molmil
Crystal structure of LysB22-AspB28 insulin analog at ambient structure
Descriptor: CHLORIDE ION, Insulin A chain, Insulin B chain, ...
Authors:Ayan, E, Demirci, H.
Deposit date:2024-04-17
Release date:2024-05-22
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structure of LysB22-AspB28 insulin analog at ambient structure
To Be Published
8VJC
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BU of 8vjc by Molmil
Cryo-EM structure of short form insulin receptor (IR-A) with three IGF2 bound, asymmetric conformation.
Descriptor: Insulin-like growth factor II, Isoform Short of Insulin receptor
Authors:An, W, Hall, C, Li, J, Huang, A, Wu, J, Park, J, Bai, X.C, Choi, E.
Deposit date:2024-01-06
Release date:2024-03-27
Last modified:2024-04-03
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Activation of the insulin receptor by insulin-like growth factor 2.
Nat Commun, 15, 2024
8VJB
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BU of 8vjb by Molmil
Cryo-EM structure of short form insulin receptor (IR-A) with four IGF2 bound, symmetric conformation.
Descriptor: Insulin-like growth factor II, Isoform Short of Insulin receptor
Authors:An, W, Hall, C, Li, J, Huang, A, Wu, J, Park, J, Bai, X.C, Choi, E.
Deposit date:2024-01-06
Release date:2024-03-27
Last modified:2024-04-03
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Activation of the insulin receptor by insulin-like growth factor 2.
Nat Commun, 15, 2024
8U4E
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BU of 8u4e by Molmil
Cryo-EM structure of long form insulin receptor (IR-B) with three IGF2 bound, asymmetric conformation.
Descriptor: Insulin receptor, Insulin-like growth factor II
Authors:An, W, Hall, C, Li, J, Huang, A, Wu, J, Park, J, Bai, X.C, Choi, E.
Deposit date:2023-09-10
Release date:2024-03-27
Last modified:2024-04-03
Method:ELECTRON MICROSCOPY (4.2 Å)
Cite:Activation of the insulin receptor by insulin-like growth factor 2.
Nat Commun, 15, 2024
8U4C
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BU of 8u4c by Molmil
Cryo-EM structure of long form insulin receptor (IR-B) with four IGF2 bound, symmetric conformation.
Descriptor: Insulin receptor, Insulin-like growth factor II
Authors:An, W, Hall, C, Li, J, Huang, A, Wu, J, Park, J, Bai, X.C, Choi, E.
Deposit date:2023-09-10
Release date:2024-03-27
Last modified:2024-04-03
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Activation of the insulin receptor by insulin-like growth factor 2.
Nat Commun, 15, 2024
8TAN
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BU of 8tan by Molmil
CryoEM structure of MFRV-VILP bound to IGF1Rzip
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Insulin-like growth factor, ...
Authors:Kirk, N.S.
Deposit date:2023-06-27
Release date:2024-01-17
Last modified:2024-01-31
Method:ELECTRON MICROSCOPY (3.05 Å)
Cite:A viral insulin-like peptide inhibits IGF-1 receptor phosphorylation and regulates IGF1R gene expression.
Mol Metab, 80, 2024
8SBD
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BU of 8sbd by Molmil
Cryo-EM structure of insulin amyloid-like fibril that is composed of two antiparallel protofilaments
Descriptor: Insulin A chain, Insulin B chain
Authors:Wang, L.W, Hall, C, Uchikawa, E, Chen, D.L, Choi, E, Zhang, X.W, Bai, X.C.
Deposit date:2023-04-03
Release date:2023-08-30
Last modified:2023-09-27
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Structural basis of insulin fibrillation.
Sci Adv, 9, 2023
8RVT
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BU of 8rvt by Molmil
Structure of full-length human insulin fibrils
Descriptor: Insulin A chain, Insulin B chain
Authors:Bardiaux, B, Suladze, S, Reif, B.
Deposit date:2024-02-02
Release date:2024-05-29
Last modified:2024-06-12
Method:SOLID-STATE NMR
Cite:Atomic resolution structure of full-length human insulin fibrils.
Proc.Natl.Acad.Sci.USA, 121, 2024
8RRP
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BU of 8rrp by Molmil
Insulin Icodec - A14E B16H B25H B29Ne-C20 diacid-LgGlu-2xAdo desB30 human insulin
Descriptor: ACETATE ION, Insulin, Insulin B chain
Authors:Schluckebier, G, Johansson, E.
Deposit date:2024-01-23
Release date:2024-07-10
Last modified:2024-07-31
Method:X-RAY DIFFRACTION (2 Å)
Cite:Enhanced disulphide bond stability contributes to the once-weekly profile of insulin icodec.
Nat Commun, 15, 2024
8PJH
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BU of 8pjh by Molmil
Crystal structure of human insulin desB30 precursor with an Aspartate-Glycine-Lysine C-peptide in dimer (T2) conformation
Descriptor: Insulin
Authors:Schluckebier, G, Johansson, E.
Deposit date:2023-06-23
Release date:2023-11-08
Last modified:2024-04-17
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Molecular engineering of insulin for recombinant expression in yeast.
Trends Biotechnol, 42, 2024
8PJC
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BU of 8pjc by Molmil
Crystal structure of human insulin desB30 precursor with an Alanine-Alanine-Lysine C-peptide in dimer (T2) conformation
Descriptor: Insulin
Authors:Schluckebier, G, Johansson, E.
Deposit date:2023-06-23
Release date:2023-11-08
Last modified:2024-04-17
Method:X-RAY DIFFRACTION (2.14 Å)
Cite:Molecular engineering of insulin for recombinant expression in yeast.
Trends Biotechnol, 42, 2024
8PI6
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BU of 8pi6 by Molmil
Crystal structure of the monomeric zinc free human insulin A22K, B3E, B26E, B29R, desB30 precursor with a Ser-Glu-Asp-Trp-Trp-Arg C-peptide and a Glu-Glu-Gly-Glu-Pro-Arg N-terminal extension
Descriptor: Insulin B chain,Insulin A chain
Authors:Johansson, E, Schluckebier, G.
Deposit date:2023-06-21
Release date:2023-11-08
Last modified:2024-04-17
Method:X-RAY DIFFRACTION (2.14 Å)
Cite:Molecular engineering of insulin for recombinant expression in yeast.
Trends Biotechnol, 42, 2024
8PI5
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BU of 8pi5 by Molmil
Crystal structure of human insulin desB30 precursor with an Alanine-Methionine-Lysine C-peptide in hexamer (T3R3) conformation
Descriptor: CHLORIDE ION, Insulin B chain,Insulin A chain, RESORCINOL, ...
Authors:Johansson, E, Schluckebier, G.
Deposit date:2023-06-21
Release date:2023-11-08
Last modified:2024-04-17
Method:X-RAY DIFFRACTION (1.66 Å)
Cite:Molecular engineering of insulin for recombinant expression in yeast.
Trends Biotechnol, 42, 2024
8PI4
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BU of 8pi4 by Molmil
Crystal structure of human insulin desB30 precursor with an Alanine-Methionine-Lysine C-peptide in dimer (T2) conformation
Descriptor: Insulin B chain,Insulin A chain
Authors:Johansson, E, Schluckebier, G.
Deposit date:2023-06-21
Release date:2023-11-08
Last modified:2024-04-17
Method:X-RAY DIFFRACTION (1.25 Å)
Cite:Molecular engineering of insulin for recombinant expression in yeast.
Trends Biotechnol, 42, 2024
8ONK
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BU of 8onk by Molmil
Human insulin in complex with the analytical antibody S1 Fab and the analytical antibody HUI-001 Fab
Descriptor: Heavy chain of analytical antibody HUI-001 Fab, Heavy chain of analytical antibody S1 Fab, Insulin A chain, ...
Authors:Johansson, E.
Deposit date:2023-04-03
Release date:2024-04-10
Method:X-RAY DIFFRACTION (3.403 Å)
Cite:Macromolecular structure of insulin and IgE clonality impacts IgE-mediated activation of sensitized basophils
To Be Published
8ONI
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BU of 8oni by Molmil
Human insulin in complex with the analytical antibody S1 Fab
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Heavy chain of analytical antibody S1 Fab, Insulin A chain, ...
Authors:Johansson, E.
Deposit date:2023-04-03
Release date:2024-04-10
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Macromolecular structure of insulin and IgE clonality impacts IgE-mediated activation of sensitized basophils
To Be Published
8IPZ
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BU of 8ipz by Molmil
Crystal structure of insulin detemir
Descriptor: CHLORIDE ION, Insulin A chain, Insulin B chain, ...
Authors:DeMirci, H, Ayan, E.
Deposit date:2023-03-15
Release date:2023-12-13
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Crystal structure of insulin detemir
To Be Published
8HSK
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BU of 8hsk by Molmil
Insulin single mutant INS-Q
Descriptor: Insulin A chain, Insulin B chain, SULFATE ION
Authors:Rao, S.S, Kundapura, S.V, Kulal, A, Ramagopal, U.A.
Deposit date:2022-12-19
Release date:2023-12-20
Method:X-RAY DIFFRACTION (1.64 Å)
Cite:Insulin single mutant INS-Q
To Be Published
8HSF
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BU of 8hsf by Molmil
Insulin triple mutant INS-RQD
Descriptor: Insulin A chain, Insulin B chain
Authors:Kundapura, S.V, Rao, S.S, Kulal, A, Ramagopal, U.A.
Deposit date:2022-12-19
Release date:2023-12-20
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Insulin triple mutant INS-RQD
To Be Published
8HGZ
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BU of 8hgz by Molmil
Crystal structure of insulin
Descriptor: CHLORIDE ION, Insulin A chain, Insulin B chain, ...
Authors:DeMirci, H, Ayan, E.
Deposit date:2022-11-16
Release date:2024-03-06
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Comparative Study of High-Resolution LysB29(N epsilon-myristoyl) des(B30) Insulin Structures Display Novel Dynamic Causal Interrelations in Monomeric-Dimeric Motions
Crystals, 13, 2023
8GSG
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BU of 8gsg by Molmil
T3R3 form of Human insulin with single Zn
Descriptor: CHLORIDE ION, Insulin A chain, Insulin B chain, ...
Authors:Zhu, Z.L.
Deposit date:2022-09-06
Release date:2023-03-15
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:T3R3 insulin with single Zn
To Be Published
8EZ0
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BU of 8ez0 by Molmil
Cryo-EM structure of 4 insulins bound full-length mouse IR mutant with physically decoupled alpha CTs (C684S/C685S/C687S; denoted as IR-3CS) Symmetric conformation
Descriptor: Insulin, Insulin receptor
Authors:Li, J, Wu, J.Y, Hall, C, Bai, X.C, Choi, E.
Deposit date:2022-10-29
Release date:2022-11-09
Last modified:2023-08-30
Method:ELECTRON MICROSCOPY (3.7 Å)
Cite:Molecular basis for the role of disulfide-linked alpha CTs in the activation of insulin-like growth factor 1 receptor and insulin receptor.
Elife, 11, 2022
8EYY
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BU of 8eyy by Molmil
Cryo-EM structure of 4 insulins bound full-length mouse IR mutant with physically decoupled alpha CTs (C684S/C685S/C687S, denoted as IR-3CS) Asymmetric conformation 2
Descriptor: Insulin, Insulin receptor
Authors:Li, J, Wu, J.Y, Hall, C, Bai, X.C, Choi, E.
Deposit date:2022-10-29
Release date:2022-11-09
Last modified:2022-12-07
Method:ELECTRON MICROSCOPY (4.9 Å)
Cite:Molecular basis for the role of disulfide-linked alpha CTs in the activation of insulin-like growth factor 1 receptor and insulin receptor.
Elife, 11, 2022
8EYX
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BU of 8eyx by Molmil
Cryo-EM structure of 4 insulins bound full-length mouse IR mutant with physically decoupled alpha CTs (C684S/C685S/C687S; denoted as IR-3CS) Asymmetric conformation 1
Descriptor: Insulin, Insulin receptor
Authors:Li, J, Wu, J.Y, Hall, C, Bai, X.C, Choi, E.
Deposit date:2022-10-29
Release date:2022-11-09
Last modified:2022-12-07
Method:ELECTRON MICROSCOPY (4.5 Å)
Cite:Molecular basis for the role of disulfide-linked alpha CTs in the activation of insulin-like growth factor 1 receptor and insulin receptor.
Elife, 11, 2022

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