8VJB

Cryo-EM structure of short form insulin receptor (IR-A) with four IGF2 bound, symmetric conformation.

Summary for 8VJB

• Entry DOI: 10.2210/pdb8vjb/pdb
• EMDB information: 41877 41878 41880 43279
• Descriptor: Isoform Short of Insulin receptor, Insulin-like growth factor II (2 entities in total)
• Functional Keywords: insulin receptor, igf2, rtk, signaling protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 6
• Total formula weight: 391339.78

Authors

An, W.,Hall, C.,Li, J.,Huang, A.,Wu, J.,Park, J.,Bai, X.C.,Choi, E. (deposition date: 2024-01-06, release date: 2024-03-27, Last modification date: 2024-04-03)

• Primary citation: An, W.,Hall, C.,Li, J.,Hung, A.,Wu, J.,Park, J.,Wang, L.,Bai, X.C.,Choi, E.; Activation of the insulin receptor by insulin-like growth factor 2.; Nat Commun, 15:2609-2609, 2024; PubMed: 38521788; DOI: 10.1038/s41467-024-46990-6

Experimental method

ELECTRON MICROSCOPY (3.6 Å)