Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

8UPA
DownloadVisualize
BU of 8upa by Molmil
Structure of gp130 in complex with a de novo designed IL-6 mimetic
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, De novo designed IL-6 mimetic, Interleukin-6 receptor subunit beta, ...
Authors:Borowska, M.T, Jude, K.M, Garcia, K.C.
Deposit date:2023-10-22
Release date:2024-08-28
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:De novo design of miniprotein antagonists of cytokine storm inducers.
Nat Commun, 15, 2024
8X80
DownloadVisualize
BU of 8x80 by Molmil
Structure of leptin-LepR trimer with a small gap
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Leptin, ...
Authors:Xie, Y.F, Gao, G.F.
Deposit date:2023-11-27
Release date:2024-08-07
Method:ELECTRON MICROSCOPY (3.88 Å)
Cite:Structural plasticity of human leptin binding to its receptor LepR
Hlife, 1, 2023
8X81
DownloadVisualize
BU of 8x81 by Molmil
Structure of leptin-LepR trimer with a large gap
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Leptin, ...
Authors:Xie, Y.F, Gao, G.F.
Deposit date:2023-11-27
Release date:2024-08-07
Method:ELECTRON MICROSCOPY (3.77 Å)
Cite:Structural plasticity of human leptin binding to its receptor LepR
Hlife, 1, 2023
8X85
DownloadVisualize
BU of 8x85 by Molmil
Structure of leptin-LepR dimer
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Leptin, Leptin receptor, ...
Authors:Xie, Y.F, Shang, G.J, Qi, J.X, Gao, G.F.
Deposit date:2023-11-27
Release date:2024-08-07
Method:ELECTRON MICROSCOPY (3.58 Å)
Cite:Structural plasticity of human leptin binding to its receptor LepR
Hlife, 1, 2023
8K3J
DownloadVisualize
BU of 8k3j by Molmil
Structure of human CNTN2 immunoglobulin domains 1-6 homo-dimer
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Contactin-2, ...
Authors:Zhang, Z.Z.
Deposit date:2023-07-16
Release date:2024-07-17
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Structure of human CNTN2 immunoglobulin domains 1-6 homo-dimer
To Be Published
9BA4
DownloadVisualize
BU of 9ba4 by Molmil
Full-length cross-linked Contactin 2 (CNTN2)
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Contactin-2
Authors:Liu, J.L, Fan, S.F, Ren, G.R, Rudenko, G.R.
Deposit date:2024-04-03
Release date:2024-07-17
Last modified:2024-07-24
Method:ELECTRON MICROSCOPY (3.54 Å)
Cite:Molecular mechanism of contactin 2 homophilic interaction.
Structure, 2024
8VVM
DownloadVisualize
BU of 8vvm by Molmil
Structure of FabS1CE1-EPR1-1 in complex with the erythropoietin receptor
Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ...
Authors:Singer, A.U, Bruce, H.A, Pavlenco, A, Ploder, L, Luu, G, Blazer, L, Adams, J.J, Sidhu, S.S.
Deposit date:2024-01-31
Release date:2024-07-10
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Antigen-binding fragments with improved crystal lattice packing and enhanced conformational flexibility at the elbow region as crystallization chaperones.
Protein Sci., 33, 2024
8VVO
DownloadVisualize
BU of 8vvo by Molmil
Structure of FabS1CE2-EPR1-1 in complex with the erythropoietin receptor
Descriptor: CHLORIDE ION, Erythropoietin receptor, S1CE2 VARIANT OF FAB-EPR-1 heavy chain, ...
Authors:Singer, A.U, Bruce, H.A, Pavlenco, A, Ploder, L, Luu, G, Blazer, L, Adams, J.J, Sidhu, S.S.
Deposit date:2024-01-31
Release date:2024-07-10
Method:X-RAY DIFFRACTION (3.09 Å)
Cite:Antigen-binding fragments with improved crystal lattice packing and enhanced conformational flexibility at the elbow region as crystallization chaperones.
Protein Sci., 33, 2024
8VUI
DownloadVisualize
BU of 8vui by Molmil
Structure of FabS1CE-EPR-1, an elbow-locked Fab, in complex with the erythropoeitin receptor
Descriptor: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, AMMONIUM ION, ...
Authors:Singer, A.U, Bruce, H.A, Blazer, L, Adams, J.J, Sidhu, S.S.
Deposit date:2024-01-29
Release date:2024-07-10
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Antigen-binding fragments with improved crystal lattice packing and enhanced conformational flexibility at the elbow region as crystallization chaperones.
Protein Sci., 33, 2024
8PEQ
DownloadVisualize
BU of 8peq by Molmil
Complex of diubiquitin-derived artificial binding protein (Affilin) variant Af2 with its target oncofetal fibronectin (fragment 7B8)
Descriptor: Affilin variant Af2, Fibronectin, SULFATE ION
Authors:Parthier, C, Katzschmann, A, Fiedler, E, Haupts, U, Reimann, A.
Deposit date:2023-06-14
Release date:2024-06-26
Last modified:2024-08-14
Method:X-RAY DIFFRACTION (2.32 Å)
Cite:Ubiquitin-derived artificial binding proteins targeting oncofetal fibronectin reveal scaffold plasticity by beta-strand slippage.
Commun Biol, 7, 2024
8T9B
DownloadVisualize
BU of 8t9b by Molmil
Structure of the CK variant of Fab F1 (FabC-F1) in complex with the C-terminal FN3 domain of EphA2
Descriptor: CK variant of Fab F1 heavy chain, CK variant of Fab F1 light chain, Ephrin type-A receptor 2
Authors:Singer, A.U, Bruce, H.A, Enderle, L, Blazer, L, Adams, J.J, Sicheri, F, Sidhu, S.S.
Deposit date:2023-06-23
Release date:2024-05-01
Method:X-RAY DIFFRACTION (4.2 Å)
Cite:Engineered Antigen-binding Fragments for Enhanced Crystallization of Antibody:Antigen Complexes
To be Published
8U4E
DownloadVisualize
BU of 8u4e by Molmil
Cryo-EM structure of long form insulin receptor (IR-B) with three IGF2 bound, asymmetric conformation.
Descriptor: Insulin receptor, Insulin-like growth factor II
Authors:An, W, Hall, C, Li, J, Huang, A, Wu, J, Park, J, Bai, X.C, Choi, E.
Deposit date:2023-09-10
Release date:2024-03-27
Last modified:2024-04-03
Method:ELECTRON MICROSCOPY (4.2 Å)
Cite:Activation of the insulin receptor by insulin-like growth factor 2.
Nat Commun, 15, 2024
8U4B
DownloadVisualize
BU of 8u4b by Molmil
Cryo-EM structure of long form insulin receptor (IR-B) in the apo state
Descriptor: Insulin receptor
Authors:An, W, Hall, C, Li, J, Huang, A, Wu, J, Park, J, Bai, X.C, Choi, E.
Deposit date:2023-09-10
Release date:2024-03-27
Last modified:2024-04-03
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Activation of the insulin receptor by insulin-like growth factor 2.
Nat Commun, 15, 2024
8U4C
DownloadVisualize
BU of 8u4c by Molmil
Cryo-EM structure of long form insulin receptor (IR-B) with four IGF2 bound, symmetric conformation.
Descriptor: Insulin receptor, Insulin-like growth factor II
Authors:An, W, Hall, C, Li, J, Huang, A, Wu, J, Park, J, Bai, X.C, Choi, E.
Deposit date:2023-09-10
Release date:2024-03-27
Last modified:2024-04-03
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Activation of the insulin receptor by insulin-like growth factor 2.
Nat Commun, 15, 2024
8VJB
DownloadVisualize
BU of 8vjb by Molmil
Cryo-EM structure of short form insulin receptor (IR-A) with four IGF2 bound, symmetric conformation.
Descriptor: Insulin-like growth factor II, Isoform Short of Insulin receptor
Authors:An, W, Hall, C, Li, J, Huang, A, Wu, J, Park, J, Bai, X.C, Choi, E.
Deposit date:2024-01-06
Release date:2024-03-27
Last modified:2024-04-03
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Activation of the insulin receptor by insulin-like growth factor 2.
Nat Commun, 15, 2024
8VJC
DownloadVisualize
BU of 8vjc by Molmil
Cryo-EM structure of short form insulin receptor (IR-A) with three IGF2 bound, asymmetric conformation.
Descriptor: Insulin-like growth factor II, Isoform Short of Insulin receptor
Authors:An, W, Hall, C, Li, J, Huang, A, Wu, J, Park, J, Bai, X.C, Choi, E.
Deposit date:2024-01-06
Release date:2024-03-27
Last modified:2024-04-03
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Activation of the insulin receptor by insulin-like growth factor 2.
Nat Commun, 15, 2024
8QY4
DownloadVisualize
BU of 8qy4 by Molmil
Structure of interleukin 11 (gp130 P496L mutant).
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Interleukin-11, ...
Authors:Gardner, S, Bubeck, D, Jin, Y.
Deposit date:2023-10-25
Release date:2024-02-21
Last modified:2024-09-04
Method:ELECTRON MICROSCOPY (3.06 Å)
Cite:Structural insights into IL-11-mediated signalling and human IL6ST variant-associated immunodeficiency.
Nat Commun, 15, 2024
8QY5
DownloadVisualize
BU of 8qy5 by Molmil
Structure of interleukin 6.
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Interleukin-6, ...
Authors:Gardner, S, Bubeck, D, Jin, Y.
Deposit date:2023-10-25
Release date:2024-02-21
Last modified:2024-09-04
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Structural insights into IL-11-mediated signalling and human IL6ST variant-associated immunodeficiency.
Nat Commun, 15, 2024
8QY6
DownloadVisualize
BU of 8qy6 by Molmil
Structure of interleukin 6 (gp130 P496L mutant).
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Interleukin-6, ...
Authors:Gardner, S, Bubeck, D, Jin, Y.
Deposit date:2023-10-25
Release date:2024-02-21
Last modified:2024-09-04
Method:ELECTRON MICROSCOPY (3.16 Å)
Cite:Structural insights into IL-11-mediated signalling and human IL6ST variant-associated immunodeficiency.
Nat Commun, 15, 2024
8ODZ
DownloadVisualize
BU of 8odz by Molmil
Cryo-EM structure of a pre-dimerized murine IL-12 complete extracellular signaling complex (Class 1).
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Interleukin-12 receptor subunit beta-1,Death-associated protein kinase 1, Interleukin-12 receptor subunit beta-2,Calmodulin-1, ...
Authors:Felix, J, Bloch, Y, Savvides, S.N.
Deposit date:2023-03-10
Release date:2024-02-07
Last modified:2024-05-01
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Structures of complete extracellular receptor assemblies mediated by IL-12 and IL-23.
Nat.Struct.Mol.Biol., 31, 2024
8OE4
DownloadVisualize
BU of 8oe4 by Molmil
Cryo-EM structure of a pre-dimerized human IL-23 complete extracellular signaling complex.
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Interleukin-12 receptor subunit beta-1,Death-associated protein kinase 1, ...
Authors:Bloch, Y, Felix, J, Savvides, S.N.
Deposit date:2023-03-10
Release date:2024-02-07
Last modified:2024-05-01
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Structures of complete extracellular receptor assemblies mediated by IL-12 and IL-23.
Nat.Struct.Mol.Biol., 31, 2024
8ODX
DownloadVisualize
BU of 8odx by Molmil
Interleukin 12 receptor subunit beta-1 Fn domains in complex with antagonistic FAb4 fragment and VHH.
Descriptor: FAb4 Heavy chain, FAb4 Light chain, Interleukin-12 receptor subunit beta-1, ...
Authors:Bloch, Y, Savvides, S.N.
Deposit date:2023-03-09
Release date:2024-02-07
Last modified:2024-05-01
Method:X-RAY DIFFRACTION (4.4 Å)
Cite:Structures of complete extracellular receptor assemblies mediated by IL-12 and IL-23.
Nat.Struct.Mol.Biol., 31, 2024
8OE0
DownloadVisualize
BU of 8oe0 by Molmil
Cryo-EM structure of a pre-dimerized murine IL-12 complete extracellular signaling complex (Class 2).
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Interleukin-12 receptor subunit beta-1,Death-associated protein kinase 1, ...
Authors:Felix, J, Bloch, Y, Savvides, S.N.
Deposit date:2023-03-10
Release date:2024-02-07
Last modified:2024-05-01
Method:ELECTRON MICROSCOPY (4.6 Å)
Cite:Structures of complete extracellular receptor assemblies mediated by IL-12 and IL-23.
Nat.Struct.Mol.Biol., 31, 2024
8PB1
DownloadVisualize
BU of 8pb1 by Molmil
Cryo-EM structure of a pre-dimerized murine IL-12 complete extracellular signaling complex (Class 1), obtained after local refinement.
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Interleukin-12 receptor subunit beta-1,Death-associated protein kinase 1, Interleukin-12 receptor subunit beta-2,Calmodulin-1, ...
Authors:Felix, J, Bloch, Y, Savvides, S.N.
Deposit date:2023-06-08
Release date:2024-02-07
Last modified:2024-05-01
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Structures of complete extracellular receptor assemblies mediated by IL-12 and IL-23.
Nat.Struct.Mol.Biol., 31, 2024
8C7M
DownloadVisualize
BU of 8c7m by Molmil
Interleukin 12 receptor subunit beta-1 Fn domains in complex with antagonistic FAb fragment.
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, FAb4 Crystal Kappa Light chain, ...
Authors:Bloch, Y, Savvides, S.N.
Deposit date:2023-01-16
Release date:2024-01-31
Last modified:2024-05-01
Method:X-RAY DIFFRACTION (2.56 Å)
Cite:Structures of complete extracellular receptor assemblies mediated by IL-12 and IL-23.
Nat.Struct.Mol.Biol., 31, 2024

225158

PDB entries from 2024-09-18

PDB statisticsPDBj update infoContact PDBjnumon