8T9B

Structure of the CK variant of Fab F1 (FabC-F1) in complex with the C-terminal FN3 domain of EphA2

Summary for 8T9B

• Entry DOI: 10.2210/pdb8t9b/pdb
• Descriptor: CK variant of Fab F1 heavy chain, CK variant of Fab F1 light chain, Ephrin type-A receptor 2 (3 entities in total)
• Functional Keywords: enhanced crystallization, epha2 binding, expressed protein, fab, complex, receptor clustering, immune system
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 12
• Total formula weight: 238492.82

Authors

Singer, A.U.,Bruce, H.A.,Enderle, L.,Blazer, L.,Adams, J.J.,Sicheri, F.,Sidhu, S.S. (deposition date: 2023-06-23, release date: 2024-05-01)

• Primary citation: Bruce, H.A.,Singer, A.U.,Filippova, E.,Blazer, L.,Adams, J.J.,Enderle, L.,Ben-David, M.,Radley, E.,Mao, D.,Pau, V.,Orlicky, S.,Sicheri, S.,Kourinov, I.,Atwell, S.,Kossiakoff, A.A.,Sidhu, S.S.; Engineered Antigen-binding Fragments for Enhanced Crystallization of Antibody:Antigen Complexes; To be Published,

Experimental method

X-RAY DIFFRACTION (4.2 Å)