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9PTI
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BU of 9pti by Molmil
BASIC PANCREATIC TRYPSIN INHIBITOR (MET 52 OXIDIZED)
Descriptor: BOVINE PANCREATIC TRYPSIN INHIBITOR, PHOSPHATE ION
Authors:Eigenbrot, C, Randal, M, Kossiakoff, A.A.
Deposit date:1991-04-08
Release date:1992-04-15
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (1.22 Å)
Cite:

8VC3
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BU of 8vc3 by Molmil
Voltage gated potassium ion channel Kv1.2 in complex with DTx
Descriptor: Kunitz-type serine protease inhibitor homolog alpha-dendrotoxin, POTASSIUM ION, Potassium voltage-gated channel subfamily A member 2
Authors:Wu, Y, Sigworth, F.J.
Deposit date:2023-12-13
Release date:2024-07-10
Last modified:2024-07-17
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Cryo-EM structures of Kv1.2 potassium channels, conducting and non-conducting.
Biorxiv, 2024
8PTI
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BU of 8pti by Molmil
CRYSTAL STRUCTURE OF A Y35G MUTANT OF BOVINE PANCREATIC TRYPSIN INHIBITOR
Descriptor: BOVINE PANCREATIC TRYPSIN INHIBITOR
Authors:Housset, D, Kim, K.-S, Fuchs, J, Woodward, C, Wlodawer, A.
Deposit date:1990-12-17
Release date:1991-04-15
Last modified:2024-06-05
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal structure of a Y35G mutant of bovine pancreatic trypsin inhibitor.
J.Mol.Biol., 220, 1991
8OTF
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BU of 8otf by Molmil
Ab typeII filament from Guam ALS/PDC
Descriptor: Amyloid-beta precursor protein
Authors:Qi, C, Yang, S, Scheres, S.H.W, Goedert, M.
Deposit date:2023-04-20
Release date:2024-03-27
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Tau filaments from amyotrophic lateral sclerosis/parkinsonism-dementia complex adopt the CTE fold.
Proc.Natl.Acad.Sci.USA, 120, 2023
8KF6
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BU of 8kf6 by Molmil
The cryo-EM structure of AV-45 bound type3 amyloid beta 42 fibril.
Descriptor: P3(40)
Authors:Zhao, Q.Y, Tao, Y.Q, Liu, C, Li, D.
Deposit date:2023-08-15
Release date:2024-08-21
Method:ELECTRON MICROSCOPY (3.7 Å)
Cite:The cryo-EM structure of type1 amyloid beta 42 fibril.
To Be Published
8KF5
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BU of 8kf5 by Molmil
The cryo-EM structure of type1 amyloid beta 42 fibril in AD3.
Descriptor: Amyloid-beta precursor protein
Authors:Zhao, Q.Y, Tao, Y.Q, Liu, C, Li, D.
Deposit date:2023-08-15
Release date:2024-08-21
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:The cryo-EM structure of type1 amyloid beta 42 fibril in AD3.
To Be Published
8KF4
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BU of 8kf4 by Molmil
The cryo-EM structure of type1 amyloid beta 42 fibril in AD2 patient.
Descriptor: Amyloid-beta precursor protein
Authors:Zhao, Q.Y, Tao, Y.Q, Liu, C, Li, D.
Deposit date:2023-08-15
Release date:2024-08-21
Method:ELECTRON MICROSCOPY (3 Å)
Cite:The cryo-EM structure of type1 amyloid beta 42 fibril in AD2 patient.
To Be Published
8KF3
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BU of 8kf3 by Molmil
The cryo-EM structure of type3 amyloid beta 42 fibril.
Descriptor: Amyloid-beta precursor protein
Authors:Zhao, Q.Y, Tao, Y.Q, Liu, C, Li, D.
Deposit date:2023-08-15
Release date:2024-08-21
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:The cryo-EM structure of type1 amyloid beta 42 fibril.
To Be Published
8KF1
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BU of 8kf1 by Molmil
The cryo-EM structure of AV-45 bound type1 amyloid beta 42 fibril.
Descriptor: 4-[2-[6-[2-[2-(2-fluoranylethoxy)ethoxy]ethoxy]pyridin-3-yl]ethyl]-~{N}-methyl-aniline, P3(40)
Authors:Zhao, Q.Y, Tao, Y.Q, Liu, C, Li, D.
Deposit date:2023-08-15
Release date:2024-08-21
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:The cryo-EM structure of AV-45 bound type1 amyloid beta 42 fibril.
To Be Published
8KEW
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BU of 8kew by Molmil
The cryo-EM structure of type1 amyloid beta 42 fibril.
Descriptor: P3(40)
Authors:Zhao, Q.Y, Tao, Y.Q, Liu, C, Li, D.
Deposit date:2023-08-13
Release date:2024-08-14
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:The cryo-EM structure of type1 amyloid beta 42 fibril.
To Be Published
7V1N
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BU of 7v1n by Molmil
Structure of the Clade 2 C. difficile TcdB in complex with its receptor TFPI
Descriptor: Isoform Beta of Tissue factor pathway inhibitor, Toxin B
Authors:Luo, J, Yang, Q, Zhang, X, Zhang, Y, Wan, L, Li, Y, Tao, L.
Deposit date:2021-08-05
Release date:2022-02-23
Last modified:2022-03-30
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:TFPI is a colonic crypt receptor for TcdB from hypervirulent clade 2 C. difficile.
Cell, 185, 2022
7QIT
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BU of 7qit by Molmil
CRYSTAL STRUCTURE OF THE P1 trifluoroethylglycine (TfeGly) BPTI MUTANT- BOVINE CHYMOTRYPSIN COMPLEX
Descriptor: Chymotrypsin A chain A, Chymotrypsin A chain B, Chymotrypsin A chain C, ...
Authors:Dimos, N, Leppkes, J, Koksch, B, Wahl, M.C, Loll, B.
Deposit date:2021-12-15
Release date:2022-03-09
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.99 Å)
Cite:Fluorine-induced polarity increases inhibitory activity of BPTI towards chymotrypsin.
Rsc Chem Biol, 3, 2022
7QIS
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BU of 7qis by Molmil
CRYSTAL STRUCTURE OF THE P1 difluoroethylglycine (DfeGly) BPTI MUTANT- BOVINE CHYMOTRYPSIN COMPLEX
Descriptor: Chymotrypsin A chain A, Chymotrypsin A chain B, Chymotrypsin A chain C, ...
Authors:Dimos, N, Leppkes, J, Koksch, B, Wahl, M.C, Loll, B.
Deposit date:2021-12-15
Release date:2022-03-09
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.83 Å)
Cite:Fluorine-induced polarity increases inhibitory activity of BPTI towards chymotrypsin.
Rsc Chem Biol, 3, 2022
7QIR
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BU of 7qir by Molmil
CRYSTAL STRUCTURE OF THE P1 monofluorethylglycine(MfeGly) BPTI MUTANT- BOVINE CHYMOTRYPSIN COMPLEX
Descriptor: Chymotrypsin A chain A, Chymotrypsin A chain B, Chymotrypsin A chain C, ...
Authors:Dimos, N, Leppkes, J, Koksch, B, Wahl, M.C, Loll, B.
Deposit date:2021-12-15
Release date:2022-03-09
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Fluorine-induced polarity increases inhibitory activity of BPTI towards chymotrypsin.
Rsc Chem Biol, 3, 2022
7QIQ
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BU of 7qiq by Molmil
CRYSTAL STRUCTURE OF THE P1 aminobutanoic acid (ABU) BPTI MUTANT- BOVINE CHYMOTRYPSIN COMPLEX
Descriptor: Chymotrypsin A chain A, Chymotrypsin A chain B, Chymotrypsin A chain C, ...
Authors:Dimos, N, Leppkes, J, Koksch, B, Wahl, M.C, Loll, B.
Deposit date:2021-12-15
Release date:2022-03-09
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Fluorine-induced polarity increases inhibitory activity of BPTI towards chymotrypsin.
Rsc Chem Biol, 3, 2022
7PTI
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BU of 7pti by Molmil
STRUCTURAL EFFECTS INDUCED BY REMOVAL OF A DISULFIDE BRIDGE. THE X-RAY STRUCTURE OF THE C30A(SLASH)C51A MUTANT OF BASIC PANCREATIC TRYPSIN INHIBITOR AT 1.6 ANGSTROMS
Descriptor: BOVINE PANCREATIC TRYPSIN INHIBITOR, PHOSPHATE ION
Authors:Eigenbrot, C, Randal, M, Kossiakoff, A.A.
Deposit date:1990-03-08
Release date:1991-04-15
Last modified:2024-06-05
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structural effects induced by removal of a disulfide-bridge: the X-ray structure of the C30A/C51A mutant of basic pancreatic trypsin inhibitor at 1.6 A.
Protein Eng., 3, 1990
7PH1
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BU of 7ph1 by Molmil
Trypsin in complex with BPTI mutant (2S)-2-amino-4-monofluorobutanoic acid
Descriptor: CALCIUM ION, Cationic trypsin, GLYCEROL, ...
Authors:Dimos, N, Leppkes, J, Koksch, B, Loll, B.
Deposit date:2021-08-16
Release date:2022-03-30
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.18 Å)
Cite:Water Network in the Binding Pocket of Fluorinated BPTI-Trypsin Complexes─Insights from Simulation and Experiment.
J.Phys.Chem.B, 126, 2022
6YHY
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BU of 6yhy by Molmil
A lid blocking mechanism of a cone snail toxin revealed at the atomic level
Descriptor: Conk-S1
Authors:Saikia, C, Altman-Gueta, H, Dym, O, Frolow, F, Gurevitz, M, Gordon, D, Reuveny, E, Karbat, I.
Deposit date:2020-03-31
Release date:2021-04-14
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:A Molecular Lid Mechanism of K + Channel Blocker Action Revealed by a Cone Peptide.
J.Mol.Biol., 433, 2021
6Q6C
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BU of 6q6c by Molmil
Pore-modulating toxins exploit inherent slow inactivation to block K+ channels
Descriptor: 1,2-ETHANEDIOL, Kunitz-type conkunitzin-S1, NITRATE ION, ...
Authors:Karbat, I, Gueta, H, Fine, S, Szanto, T, Hamer-Rogotner, S, Dym, O, Frolow, F, Gordon, D, Panyi, G, Gurevitz, M, Reuveny, E.
Deposit date:2018-12-10
Release date:2019-08-21
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Pore-modulating toxins exploit inherent slow inactivation to block K+channels.
Proc.Natl.Acad.Sci.USA, 116, 2019
6Q61
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BU of 6q61 by Molmil
Pore-modulating toxins exploit inherent slow inactivation to block K+ channels
Descriptor: Kunitz-type conkunitzin-S1, SULFATE ION
Authors:Karbat, I, Gueta, H, Fine, S, Szanto, T, Hamer-Rogotner, S, Dym, O, Frolow, F, Gordon, D, Panyi, G, Gurevitz, M, Reuveny, E.
Deposit date:2018-12-10
Release date:2019-08-21
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Pore-modulating toxins exploit inherent slow inactivation to block K+channels.
Proc.Natl.Acad.Sci.USA, 116, 2019
6PTI
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BU of 6pti by Molmil
STRUCTURE OF FORM III CRYSTALS OF BOVINE PANCREATIC TRYPSIN INHIBITOR
Descriptor: PANCREATIC TRYPSIN INHIBITOR PRECURSOR, PHOSPHATE ION
Authors:Wlodawer, A.
Deposit date:1987-05-13
Release date:1987-10-16
Last modified:2024-06-05
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structure of form III crystals of bovine pancreatic trypsin inhibitor.
J.Mol.Biol., 198, 1987
6NAN
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BU of 6nan by Molmil
NMR structure determination of Ixolaris and Factor X interaction reveals a noncanonical mechanism of Kunitz inhibition
Descriptor: Ixolaris
Authors:De Paula, V.S, Sgourakis, N.G, Francischetti, I.M.B, Almeida, F.C.L, Monteiro, R.Q, Valente, A.P.
Deposit date:2018-12-06
Release date:2019-06-12
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:NMR structure determination of Ixolaris and factor X(a) interaction reveals a noncanonical mechanism of Kunitz inhibition.
Blood, 134, 2019
6KZF
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BU of 6kzf by Molmil
Racemic X-ray Structure of Calcicludine
Descriptor: D-calcicludine, Kunitz-type serine protease inhibitor homolog calcicludine
Authors:Qu, Q, Gao, S, Liu, L.
Deposit date:2019-09-24
Release date:2019-11-06
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.52 Å)
Cite:Synthesis of Disulfide Surrogate Peptides Incorporating Large-Span Surrogate Bridges Through a Native-Chemical-Ligation-Assisted Diaminodiacid Strategy
Angew.Chem.Int.Ed.Engl., 59, 2020
6HAR
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BU of 6har by Molmil
Crystal structure of Mesotrypsin in complex with APPI-M17C/I18F/F34C
Descriptor: 1,2-ETHANEDIOL, Amyloid-beta A4 protein, CALCIUM ION, ...
Authors:Shahar, A, Cohen, I, Radisky, E, Papo, N.
Deposit date:2018-08-08
Release date:2019-02-06
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.497 Å)
Cite:Disulfide engineering of human Kunitz-type serine protease inhibitors enhances proteolytic stability and target affinity toward mesotrypsin.
J.Biol.Chem., 294, 2019
6GFI
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BU of 6gfi by Molmil
Structure of Human Mesotrypsin in complex with APPI variant T11V/M17R/I18F/F34V
Descriptor: 1,2-ETHANEDIOL, Amyloid-beta A4 protein, PRSS3 protein
Authors:Shahar, A, Cohen, I, Radisky, E, Papo, N, Naftaly, S.
Deposit date:2018-04-30
Release date:2018-09-12
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Mapping protein selectivity landscapes using multi-target selective screening and next-generation sequencing of combinatorial libraries.
Nat Commun, 9, 2018

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