8OTF

Ab typeII filament from Guam ALS/PDC

Summary for 8OTF

• Entry DOI: 10.2210/pdb8otf/pdb
• Related: 8OTE
• EMDB information: 17177
• Descriptor: Amyloid-beta precursor protein (1 entity in total)
• Functional Keywords: ab typeii filaments, guam als/pdc, protein fibril
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 6
• Total formula weight: 522277.31

Authors

Qi, C.,Yang, S.,Scheres, S.H.W.,Goedert, M. (deposition date: 2023-04-20, release date: 2024-03-27)

• Primary citation: Qi, C.,Verheijen, B.M.,Kokubo, Y.,Shi, Y.,Tetter, S.,Murzin, A.G.,Nakahara, A.,Morimoto, S.,Vermulst, M.,Sasaki, R.,Aronica, E.,Hirokawa, Y.,Oyanagi, K.,Kakita, A.,Ryskeldi-Falcon, B.,Yoshida, M.,Hasegawa, M.,Scheres, S.H.W.,Goedert, M.; Tau filaments from amyotrophic lateral sclerosis/parkinsonism-dementia complex adopt the CTE fold.; Proc.Natl.Acad.Sci.USA, 120:e2306767120-e2306767120, 2023; PubMed: 38100415; DOI: 10.1073/pnas.2306767120

Experimental method

ELECTRON MICROSCOPY (3.3 Å)