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1NGN
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BU of 1ngn by Molmil
Mismatch repair in methylated DNA. Structure of the mismatch-specific thymine glycosylase domain of methyl-CpG-binding protein MBD4
Descriptor: methyl-CpG binding protein MBD4
Authors:Wu, P, Qiu, C, Sohail, A, Zhang, X, Bhagwat, A.S, Cheng, X.
Deposit date:2002-12-17
Release date:2003-03-18
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Mismatch repair in methylated DNA. Structure and activity of the mismatch-specific thymine glycosylase domain of methyl-CpG-binding protein MBD4
J.Biol.Chem., 278, 2003
2MOE
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BU of 2moe by Molmil
Solution structure of MBD4 methyl-cytosine binding domain bound to methylated DNA
Descriptor: DNA (5'-D(*GP*AP*GP*CP*(5CM)P*GP*AP*TP*CP*C)-3'), DNA (5'-D(*GP*GP*AP*TP*(5CM)P*GP*GP*CP*TP*C)-3'), Methyl-CpG-binding domain protein 4
Authors:Williams, D.C, Walavalkar, N.M.
Deposit date:2014-04-24
Release date:2014-09-10
Last modified:2024-05-15
Method:SOLUTION NMR
Cite:Solution structure and intramolecular exchange of methyl-cytosine binding domain protein 4 (MBD4) on DNA suggests a mechanism to scan for mCpG/TpG mismatches.
Nucleic Acids Res., 42, 2015
7KZ0
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BU of 7kz0 by Molmil
Human MBD4 glycosylase domain bound to DNA containing substrate analog 2'-deoxy-pseudouridine
Descriptor: DNA (5'-D(*CP*CP*AP*GP*CP*GP*(P2U)P*GP*CP*AP*GP*C)-3'), DNA (5'-D(*GP*CP*TP*GP*CP*GP*CP*GP*CP*TP*GP*G)-3'), GLYCEROL, ...
Authors:Pidugu, L.S, Pozharski, E, Drohat, A.C.
Deposit date:2020-12-09
Release date:2021-11-10
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.57 Å)
Cite:Structural Insights into the Mechanism of Base Excision by MBD4.
J.Mol.Biol., 433, 2021
7KZG
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BU of 7kzg by Molmil
Human MBD4 glycosylase domain bound to DNA containing oxacarbenium-ion analog 1-aza-2'-deoxyribose
Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ...
Authors:Pidugu, L.S, Pozharski, E, Drohat, A.C.
Deposit date:2020-12-10
Release date:2021-11-10
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.68 Å)
Cite:Structural Insights into the Mechanism of Base Excision by MBD4.
J.Mol.Biol., 433, 2021
7KZ1
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BU of 7kz1 by Molmil
Human MBD4 glycosylase domain bound to DNA containing an abasic site
Descriptor: 1,2-ETHANEDIOL, DNA (5'-D(*CP*CP*AP*GP*CP*GP*(ORP)P*GP*CP*AP*GP*C)-3'), DNA (5'-D(*GP*CP*TP*GP*CP*GP*CP*GP*CP*TP*GP*G)-3'), ...
Authors:Pidugu, L.S, Bright, H, Pozharski, E, Drohat, A.C.
Deposit date:2020-12-09
Release date:2021-11-10
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.62 Å)
Cite:Structural Insights into the Mechanism of Base Excision by MBD4.
J.Mol.Biol., 433, 2021
4E9E
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BU of 4e9e by Molmil
Structure of the glycosylase domain of MBD4
Descriptor: Methyl-CpG-binding domain protein 4
Authors:Morera, S, Vigouroux, A.
Deposit date:2012-03-21
Release date:2012-08-08
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Biochemical and structural characterization of the glycosylase domain of MBD4 bound to thymine and 5-hydroxymethyuracil-containing DNA.
Nucleic Acids Res., 40, 2012
4E9H
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BU of 4e9h by Molmil
structure of glycosylase domain of MBD4 bound to 5hmU containing DNA
Descriptor: DNA (5'-D(*CP*CP*AP*GP*CP*GP*(5HU)P*GP*CP*AP*GP*C)-3'), DNA (5'-D(*GP*CP*TP*GP*CP*GP*CP*GP*CP*TP*GP*G)-3'), Methyl-CpG-binding domain protein 4
Authors:Morera, S, Vigouroux, A.
Deposit date:2012-03-21
Release date:2012-08-08
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (3 Å)
Cite:Biochemical and structural characterization of the glycosylase domain of MBD4 bound to thymine and 5-hydroxymethyuracil-containing DNA.
Nucleic Acids Res., 40, 2012
4EA5
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BU of 4ea5 by Molmil
Structure of the glycoslyase domain of MBD4 bound to a 5hmU containing DNA
Descriptor: DNA (5'-D(*CP*CP*AP*GP*CP*GP*(5HU)*GP*CP*AP*GP*C)-3'), DNA (5'-D(*GP*CP*TP*GP*CP*GP*CP*GP*CP*TP*GP*G)-3'), Methyl-CpG-binding domain protein 4
Authors:Morera, S, Vigouroux, A.
Deposit date:2012-03-22
Release date:2012-08-08
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.14 Å)
Cite:Biochemical and structural characterization of the glycosylase domain of MBD4 bound to thymine and 5-hydroxymethyuracil-containing DNA.
Nucleic Acids Res., 40, 2012
4E9G
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BU of 4e9g by Molmil
structure of the glycosylase domain of MBD4 bound to thymine containing DNA
Descriptor: DNA (5'-D(*CP*CP*AP*GP*CP*GP*TP*GP*CP*AP*GP*C)-3'), DNA (5'-D(*GP*CP*TP*GP*CP*GP*CP*GP*CP*TP*GP*G)-3'), Methyl-CpG-binding domain protein 4
Authors:Morera, S, Vigouroux, A.
Deposit date:2012-03-21
Release date:2012-08-08
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Biochemical and structural characterization of the glycosylase domain of MBD4 bound to thymine and 5-hydroxymethyuracil-containing DNA.
Nucleic Acids Res., 40, 2012
4E9F
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BU of 4e9f by Molmil
Structure of the glycosylase domain of MBD4 bound to AP site containing DNA
Descriptor: 1,2-ETHANEDIOL, DNA (5'-D(*CP*CP*AP*GP*CP*GP*(3DR)P*GP*CP*AP*GP*C)-3'), DNA (5'-D(*GP*CP*TP*GP*CP*GP*CP*GP*CP*TP*GP*G)-3'), ...
Authors:Morera, S, Vigouroux, A.
Deposit date:2012-03-21
Release date:2012-08-08
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.79 Å)
Cite:Biochemical and structural characterization of the glycosylase domain of MBD4 bound to thymine and 5-hydroxymethyuracil-containing DNA.
Nucleic Acids Res., 40, 2012
4EA4
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BU of 4ea4 by Molmil
Structure of the glycosylase domain of MBD4 bound to 5hmU-containing DNA
Descriptor: DNA (5'-D(*CP*CP*AP*GP*CP*GP*(5HU)P*GP*CP*AP*GP*C)-3'), DNA (5'-D(*GP*CP*TP*GP*CP*GP*CP*GP*CP*TP*GP*G)-3'), Methyl-CpG-binding domain protein 4
Authors:Morera, S, Vigouroux, A.
Deposit date:2012-03-22
Release date:2012-08-08
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Biochemical and structural characterization of the glycosylase domain of MBD4 bound to thymine and 5-hydroxymethyuracil-containing DNA.
Nucleic Acids Res., 40, 2012
4EW0
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BU of 4ew0 by Molmil
mouse MBD4 glycosylase domain in complex with a G:5hmU (5-hydroxymethyluracil) mismatch
Descriptor: 1,2-ETHANEDIOL, DNA (5'-D(*CP*CP*AP*TP*GP*(5HU)P*GP*CP*TP*GP*A)-3'), DNA (5'-D(*TP*CP*AP*GP*CP*GP*CP*AP*TP*GP*G)-3'), ...
Authors:Hashimoto, H, Zhang, X, Cheng, X.
Deposit date:2012-04-26
Release date:2012-07-11
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.39 Å)
Cite:Excision of thymine and 5-hydroxymethyluracil by the MBD4 DNA glycosylase domain: structural basis and implications for active DNA demethylation.
Nucleic Acids Res., 40, 2012
4EW4
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BU of 4ew4 by Molmil
mouse MBD4 glycosylase domain in complex with DNA containing a ribose sugar
Descriptor: DNA (5'-D(*CP*CP*AP*TP*GP*(3DR)P*GP*CP*TP*GP*A)-3'), DNA (5'-D(*TP*CP*AP*GP*CP*GP*CP*AP*TP*GP*G)-3'), Methyl-CpG-binding domain protein 4, ...
Authors:Hashimoto, H, Zhang, X, Cheng, X.
Deposit date:2012-04-26
Release date:2012-07-11
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.791 Å)
Cite:Excision of thymine and 5-hydroxymethyluracil by the MBD4 DNA glycosylase domain: structural basis and implications for active DNA demethylation.
Nucleic Acids Res., 40, 2012
4EVV
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BU of 4evv by Molmil
mouse MBD4 glycosylase domain in complex with a G:T mismatch
Descriptor: 1,2-ETHANEDIOL, DNA (5'-D(*CP*CP*AP*TP*GP*TP*GP*CP*TP*GP*A)-3'), DNA (5'-D(*TP*CP*AP*GP*CP*GP*CP*AP*TP*GP*G)-3'), ...
Authors:Hashimoto, H, Zhang, X, Cheng, X.
Deposit date:2012-04-26
Release date:2012-07-11
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.39 Å)
Cite:Excision of thymine and 5-hydroxymethyluracil by the MBD4 DNA glycosylase domain: structural basis and implications for active DNA demethylation.
Nucleic Acids Res., 40, 2012
3IHO
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BU of 3iho by Molmil
The C-terminal glycosylase domain of human MBD4
Descriptor: Methyl-CpG-binding domain protein 4
Authors:Amaya, M.F, Xu, C, Bian, C.B, Bountra, C, Weigelt, J, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Min, J, Structural Genomics Consortium (SGC)
Deposit date:2009-07-30
Release date:2009-08-25
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:The C-terminal glycosylase domain of human MBD4
To be Published
5CHZ
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BU of 5chz by Molmil
Structure of wild-type human MBD4 bound to a G:T mismatch
Descriptor: 12-mer DNA(G), 5-mer DNA, 7-mer DNA, ...
Authors:Ouzon-Shubeita, H, Lin, Y.-L, Lee, S.
Deposit date:2015-07-10
Release date:2016-07-20
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.83 Å)
Cite:Structure of wild-type human MBD4 bound to a G:T mismatch
To Be Published
4LG7
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BU of 4lg7 by Molmil
Crystal structure MBD4 MBD domain in complex with methylated CpG DNA
Descriptor: DNA (5'-D(*GP*CP*CP*AP*AP*(5CM)P*GP*TP*TP*GP*GP*C)-3'), Methyl-CpG-binding domain protein 4, UNKNOWN ATOM OR ION
Authors:Xu, C, Tempel, W, Wernimont, A.K, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC)
Deposit date:2013-06-27
Release date:2013-07-17
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structure MBD4 MBD domain in complex with methylated CpG DNA
To be Published
6VJW
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BU of 6vjw by Molmil
Crystal structure of WT hMBD4 complexed with T:G mismatch DNA
Descriptor: DNA (5'-D(*CP*CP*AP*GP*CP*GP*(ORP)P*GP*CP*AP*GP*C)-3'), DNA (5'-D(*GP*CP*TP*GP*CP*GP*CP*GP*CP*TP*GP*G)-3'), Methyl-CpG-binding domain protein 4
Authors:Jung, H, Lee, S.
Deposit date:2020-01-17
Release date:2021-01-27
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.02 Å)
Cite:Catalytic mechanism of the mismatch-specific DNA glycosylase methyl-CpG-binding domain 4.
Biochem.J., 477, 2020
3VXV
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BU of 3vxv by Molmil
Crystal structure of methyl CpG Binding Domain of MBD4 in complex with the 5mCG/TG sequence
Descriptor: 1,2-ETHANEDIOL, ACETATE ION, DNA (5'-D(*GP*TP*CP*AP*CP*TP*AP*CP*(5CM)P*GP*GP*AP*CP*A)-3'), ...
Authors:Otani, J, Arita, K, Kato, T, Kinoshita, M, Ariyoshi, M, Shirakawa, M.
Deposit date:2012-09-21
Release date:2013-01-16
Last modified:2013-08-14
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural basis of the versatile DNA recognition ability of the methyl-CpG binding domain of methyl-CpG binding domain protein 4
J.Biol.Chem., 288, 2013
3VYB
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BU of 3vyb by Molmil
Crystal structure of methyl CpG binding domain of MBD4 in complex with the 5mCG/hmCG sequence
Descriptor: 1,2-ETHANEDIOL, ACETATE ION, DNA (5'-D(*GP*TP*CP*(5HC)P*GP*GP*TP*AP*GP*TP*GP*AP*CP*T)-3'), ...
Authors:Otani, J, Arita, K, Kato, T, Kinoshita, M, Ariyoshi, M, Shirakawa, M.
Deposit date:2012-09-22
Release date:2013-01-16
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural basis of the versatile DNA recognition ability of the methyl-CpG binding domain of methyl-CpG binding domain protein 4
J.Biol.Chem., 288, 2013
3VXX
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BU of 3vxx by Molmil
Crystal structure of methyl CpG binding domain of MBD4 in complex with the 5mCG/5mCG sequence
Descriptor: 1,2-ETHANEDIOL, ACETATE ION, DNA (5'-D(*GP*TP*CP*(5CM)P*GP*GP*TP*AP*GP*TP*GP*AP*CP*T)-3'), ...
Authors:Otani, J, Arita, K, Kato, T, Kinoshita, M, Ariyoshi, M, Shirakawa, M.
Deposit date:2012-09-21
Release date:2013-01-16
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.204 Å)
Cite:Structural basis of the versatile DNA recognition ability of the methyl-CpG binding domain of methyl-CpG binding domain protein 4
J.Biol.Chem., 288, 2013
3VYQ
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BU of 3vyq by Molmil
Crystal structure of the methyl CpG Binding Domain of MBD4 in complex with the 5mCG/TG sequence in space group P1
Descriptor: 1,2-ETHANEDIOL, DNA (5'-D(*AP*CP*AP*TP*CP*(5CM)P*GP*GP*TP*GP*A)-3'), DNA (5'-D(*TP*CP*AP*CP*TP*GP*GP*AP*TP*GP*T)-3'), ...
Authors:Otani, J, Arita, K, Kato, T, Kinoshita, M, Ariyoshi, M, Shirakawa, M.
Deposit date:2012-10-02
Release date:2013-01-16
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.525 Å)
Cite:Structural basis of the versatile DNA recognition ability of the methyl-CpG binding domain of methyl-CpG binding domain protein 4
J.Biol.Chem., 288, 2013
4OFH
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BU of 4ofh by Molmil
Structural basis for thymine glycosylase activity on T:O6-methylG mismatch by methyl-CpG binding domain protein 4: Implications for roles of Arg468 in mismatch recognition and catalysis
Descriptor: 12-mer DNA(O6MeG), 12-mer DNA(T), MAGNESIUM ION, ...
Authors:Ouzon-Shubeita, H, Lin, Y.-L, Lee, S.
Deposit date:2014-01-14
Release date:2015-04-22
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.22 Å)
Cite:Structure of MBD4 bound to O6MeG:T mispair DNA
To be Published
4OFE
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BU of 4ofe by Molmil
Structural basis for thymine glycosylase activity on T:O6-methylG mismatch by methyl-CpG binding domain protein 4: Implications for roles of Arg468 in mismatch recognition and catalysis
Descriptor: 12-mer DNA(G), 12-mer DNA(T), MAGNESIUM ION, ...
Authors:Ouzon-Shubeita, H, Lin, Y.-L, Lee, S.
Deposit date:2014-01-14
Release date:2015-04-22
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Structure of R468K/D560N MBD4 bound to G:T mispair DNA
To be Published
4OFA
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BU of 4ofa by Molmil
Structural basis for thymine glycosylase activity on T:O6-methylG mismatch by methyl-CpG binding domain protein 4: Implications for roles of Arg468 in mismatch recognition and catalysis
Descriptor: 12-mer DNA(G), 12-mer DNA(T), MAGNESIUM ION, ...
Authors:Ouzon-Shubeita, H, Lin, Y.-L, Lee, S.
Deposit date:2014-01-14
Release date:2015-04-22
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Structure of MBD4 bound to G:T mispair DNA
To be Published

 

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