4OFH

Structural basis for thymine glycosylase activity on T:O6-methylG mismatch by methyl-CpG binding domain protein 4: Implications for roles of Arg468 in mismatch recognition and catalysis

Summary for 4OFH

• Entry DOI: 10.2210/pdb4ofh/pdb
• Related: 3IHO 4E9E 4E9F 4E9G 4EA4 4EA5 4OFA 4OFE
• Descriptor: Methyl-CpG-binding domain protein 4, 12-mer DNA(T), 12-mer DNA(O6MeG), ... (5 entities in total)
• Functional Keywords: protein-dna complex, mismatch, thymine glycosylase, hydrolase-dna complex, hydrolase/dna
• Biological source: Homo sapiens (human); More
• Cellular location: Nucleus: O95243
• Total number of polymer chains: 3
• Total formula weight: 29868.95

Authors

Ouzon-Shubeita, H.,Lin, Y.-L.,Lee, S. (deposition date: 2014-01-14, release date: 2015-04-22, Last modification date: 2023-09-20)

• Primary citation: Ouzon-Shubeita, H.,Lin, Y.-L.,Lee, S.; Structure of MBD4 bound to O6MeG:T mispair DNA; To be Published,

Experimental method

X-RAY DIFFRACTION (2.22 Å)