4EW0
mouse MBD4 glycosylase domain in complex with a G:5hmU (5-hydroxymethyluracil) mismatch
Summary for 4EW0
Entry DOI | 10.2210/pdb4ew0/pdb |
Related | 1NGN 4EVV 4EW4 |
Descriptor | Methyl-CpG-binding domain protein 4, DNA (5'-D(*TP*CP*AP*GP*CP*GP*CP*AP*TP*GP*G)-3'), DNA (5'-D(*CP*CP*AP*TP*GP*(5HU)P*GP*CP*TP*GP*A)-3'), ... (6 entities in total) |
Functional Keywords | 5-hydroxymethyluracil, deamination, 5-methylcytosine, active dna demethylation, helix-hairpin-helix, dna glycosylase, hydrolase-dna complex, hydrolase/dna |
Biological source | Mus musculus (mouse) More |
Cellular location | Nucleus: Q9Z2D7 |
Total number of polymer chains | 3 |
Total formula weight | 24547.51 |
Authors | Hashimoto, H.,Zhang, X.,Cheng, X. (deposition date: 2012-04-26, release date: 2012-07-11, Last modification date: 2023-09-13) |
Primary citation | Hashimoto, H.,Zhang, X.,Cheng, X. Excision of thymine and 5-hydroxymethyluracil by the MBD4 DNA glycosylase domain: structural basis and implications for active DNA demethylation. Nucleic Acids Res., 40:8276-8284, 2012 Cited by PubMed: 22740654DOI: 10.1093/nar/gks628 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.39 Å) |
Structure validation
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