2MOE
Solution structure of MBD4 methyl-cytosine binding domain bound to methylated DNA
Summary for 2MOE
Entry DOI | 10.2210/pdb2moe/pdb |
NMR Information | BMRB: 19939 |
Descriptor | Methyl-CpG-binding domain protein 4, DNA (5'-D(*GP*GP*AP*TP*(5CM)P*GP*GP*CP*TP*C)-3'), DNA (5'-D(*GP*AP*GP*CP*(5CM)P*GP*AP*TP*CP*C)-3') (3 entities in total) |
Functional Keywords | protein/dna, methylated dna, hydrolase-dna complex, hydrolase/dna |
Biological source | Homo sapiens (human) |
Cellular location | Nucleus: O95243 |
Total number of polymer chains | 3 |
Total formula weight | 14207.29 |
Authors | Williams, D.C.,Walavalkar, N.M. (deposition date: 2014-04-24, release date: 2014-09-10, Last modification date: 2024-05-15) |
Primary citation | Walavalkar, N.M.,Cramer, J.M.,Buchwald, W.A.,Scarsdale, J.N.,Williams, D.C. Solution structure and intramolecular exchange of methyl-cytosine binding domain protein 4 (MBD4) on DNA suggests a mechanism to scan for mCpG/TpG mismatches. Nucleic Acids Res., 42:11218-11232, 2015 Cited by PubMed: 25183517DOI: 10.1093/nar/gku782 PDB entries with the same primary citation |
Experimental method | SOLUTION NMR |
Structure validation
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