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3MDC
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BU of 3mdc by Molmil
DNA polymerase lambda in complex with dFdCTP
Descriptor: 2'-deoxy-2',2'-difluorocytidine 5'-(tetrahydrogen triphosphate), DNA (5'-D(*CP*AP*GP*TP*AP*C)-3'), DNA (5'-D(*CP*GP*GP*CP*GP*GP*TP*AP*CP*TP*G)-3'), ...
Authors:Garcia-Diaz, M, Murray, M, Kunkel, T, Chou, K.M.
Deposit date:2010-03-30
Release date:2010-04-28
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.999 Å)
Cite:Interaction between DNA Polymerase lambda and anticancer nucleoside analogs.
J.Biol.Chem., 285, 2010
2DFD
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BU of 2dfd by Molmil
Crystal Structure of Human Malate Dehydrogenase Type 2
Descriptor: ALANINE, CHLORIDE ION, D-MALATE, ...
Authors:Ugochukwu, E, Shafqat, N, Rojkova, A, Sundstrom, M, Arrowsmith, C, Weigelt, J, Edwards, A, von Delft, F, Oppermann, U, Structural Genomics Consortium (SGC)
Deposit date:2006-02-28
Release date:2006-03-28
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal Structure of Human Malate Dehydrogenase Type 2
To be Published
8DFD
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BU of 8dfd by Molmil
CryoEM structure of the 2:1 ADP-tetrafluoroaluminate stabilized nitrogenase complex from Azotobacter vinelandii
Descriptor: 3-HYDROXY-3-CARBOXY-ADIPIC ACID, ADENOSINE-5'-DIPHOSPHATE, FE (III) ION, ...
Authors:Warmack, R.A, Rees, D.C.
Deposit date:2022-06-21
Release date:2023-06-28
Last modified:2024-04-17
Method:ELECTRON MICROSCOPY (2.12 Å)
Cite:Anaerobic cryoEM protocols for air-sensitive nitrogenase proteins.
Nat Protoc, 2024
6DFD
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BU of 6dfd by Molmil
Crystal structure of CNNM3 cyclic nucleotide-binding homology domain
Descriptor: Metal transporter CNNM3
Authors:Kozlov, G, Gehring, K.
Deposit date:2018-05-14
Release date:2018-10-31
Last modified:2019-01-16
Method:X-RAY DIFFRACTION (1.901 Å)
Cite:The cyclic nucleotide-binding homology domain of the integral membrane protein CNNM mediates dimerization and is required for Mg2+efflux activity.
J. Biol. Chem., 293, 2018
4DFD
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BU of 4dfd by Molmil
Crystal structure of had family enzyme bt-2542 (target efi-501088) from bacteroides thetaiotaomicron, magnesium complex
Descriptor: CHLORIDE ION, MAGNESIUM ION, Putative haloacid dehalogenase-like hydrolase, ...
Authors:Patskovsky, Y, Toro, R, Bhosle, R, Hillerich, B, Seidel, R.D, Washington, E, Scott Glenn, A, Chowdhury, S, Evans, B, Hammonds, J, Zencheck, W.D, Imker, H.J, Gerlt, J.A, Allen, K, Dunaway-Mariano, D, Almo, S.C, Enzyme Function Initiative (EFI)
Deposit date:2012-01-23
Release date:2012-02-01
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal Structure of Protein Bt-2542 from Bacteroides Thetaiotaomicron (Target Efi-501088)
To be Published
5DFD
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BU of 5dfd by Molmil
Crystal structure of BRD2(BD2) W370F mutant with ligand 28 bound
Descriptor: Bromodomain-containing protein 2, GLYCEROL, methyl [(4S)-6-(1H-indol-4-yl)-8-methoxy-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-4-yl]acetate
Authors:Tallant, C, Baud, M, Lin-Shiao, E, Chirgadze, D.Y, Ciulli, A.
Deposit date:2015-08-26
Release date:2015-11-11
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:New Synthetic Routes to Triazolo-benzodiazepine Analogues: Expanding the Scope of the Bump-and-Hole Approach for Selective Bromo and Extra-Terminal (BET) Bromodomain Inhibition.
J.Med.Chem., 59, 2016
1DFD
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BU of 1dfd by Molmil
OXIDISED DESULFOVIBRIO AFRICANUS FERREDOXIN I, NMR, 19 STRUCTURES
Descriptor: FERREDOXIN I, IRON/SULFUR CLUSTER
Authors:Davy, S.L, Osborne, M.J, Moore, G.R.
Deposit date:1997-12-01
Release date:1999-01-13
Last modified:2024-05-22
Method:SOLUTION NMR
Cite:Determination of the structure of oxidised Desulfovibrio africanus ferredoxin I by 1H NMR spectroscopy and comparison of its solution structure with its crystal structure.
J.Mol.Biol., 277, 1998
6DJ3
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BU of 6dj3 by Molmil
Crystal structure of CNNM2 cyclic nucleotide-binding homology domain
Descriptor: 1,2-ETHANEDIOL, Metal transporter CNNM2
Authors:Chen, Y.S, Gehring, K.
Deposit date:2018-05-24
Release date:2018-10-31
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:The cyclic nucleotide-binding homology domain of the integral membrane protein CNNM mediates dimerization and is required for Mg2+efflux activity.
J. Biol. Chem., 293, 2018
2AC3
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BU of 2ac3 by Molmil
Structure of human Mnk2 Kinase Domain
Descriptor: MAP kinase-interacting serine/threonine kinase 2, ZINC ION
Authors:Jauch, R, Wahl, M.C, Netter, C, Jakel, S, Schreiter, K, Aicher, B, Jackle, H.
Deposit date:2005-07-18
Release date:2005-10-04
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal structures of the Mnk2 kinase domain reveal an inhibitory conformation and a zinc binding site.
Structure, 13, 2005
2QNY
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BU of 2qny by Molmil
Crystal structure of the complex between the A246F mutant of mycobacterium beta-ketoacyl-acyl carrier protein synthase III (FABH) and SS-(2-hydroxyethyl) O-decyl ester carbono(dithioperoxoic) acid
Descriptor: 3-oxoacyl-[acyl-carrier-protein] synthase 3, BETA-MERCAPTOETHANOL, DECYL FORMATE
Authors:Sachdeva, S, Musayev, F, Alhamadsheh, M, Scarsdale, J.N, Wright, H.T, Reynolds, K.A.
Deposit date:2007-07-19
Release date:2008-05-06
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Separate Entrance and Exit Portals for Ligand Traffic in Mycobacterium tuberculosis FabH
Chem.Biol., 15, 2008
2QNZ
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BU of 2qnz by Molmil
Crystal structure of the complex between the mycobacterium beta-ketoacyl-acyl carrier protein synthase III (FABH) and SS-(2-hydroxyethyl)-O-decyl ester carbono(dithioperoxoic) acid
Descriptor: 3-oxoacyl-[acyl-carrier-protein] synthase 3, BETA-MERCAPTOETHANOL, DECYL FORMATE
Authors:Sachdeva, S, Musayev, F, Alhamadsheh, M, Scarsdale, J.N, Wright, H.T, Reynolds, K.A.
Deposit date:2007-07-19
Release date:2008-05-06
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Separate Entrance and Exit Portals for Ligand Traffic in Mycobacterium tuberculosis FabH
Chem.Biol., 15, 2008
4F72
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BU of 4f72 by Molmil
Crystal structure of had family enzyme bt-2542 (target efi-501088) from Bacteroides thetaiotaomicron, asp12ala mutant, complex with magnesium and inorganic phosphate
Descriptor: GLYCEROL, MAGNESIUM ION, PHOSPHATE ION, ...
Authors:Patskovsky, Y, Farelli, J.D, Toro, R, Bhosle, R, Hillerich, B, Seidel, R.D, Washington, E, Scott Glenn, A, Chowdhury, S, Evans, B, Hammonds, J, Imker, H.J, Zencheck, W.D, Gerlt, J.A, Allen, K.N, Dunaway-Mariano, D, Almo, S.C, Enzyme Function Initiative (EFI)
Deposit date:2012-05-15
Release date:2012-06-20
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal Structure of Protein Bt-2542 from Bacteroides Thetaiotaomicron (Target Efi-501088)
To be Published
4F71
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BU of 4f71 by Molmil
Crystal structure of had family enzyme bt-2542 (target efi-501088) from Bacteroides thetaiotaomicron, wild-type protein, complex with magnesium and inorganic phosphate
Descriptor: CHLORIDE ION, GLYCEROL, MAGNESIUM ION, ...
Authors:Patskovsky, Y, Toro, R, Bhosle, R, Hillerich, B, Seidel, R.D, Washington, E, Scott Glenn, A, Chowdhury, S, Evans, B, Hammonds, J, Zencheck, W.D, Imker, H.J, Gerlt, J.A, Allen, K.N, Dunaway-Mariano, D, Almo, S.C, Enzyme Function Initiative (EFI)
Deposit date:2012-05-15
Release date:2012-06-20
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.27 Å)
Cite:Crystal Structure of Protein Bt-2542 from Bacteroides Thetaiotaomicron (Target Efi-501088)
To be Published
6FKR
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BU of 6fkr by Molmil
Crystal structure of the dolphin proline-rich antimicrobial peptide Tur1A bound to the Thermus thermophilus 70S ribosome
Descriptor: 16 ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ...
Authors:Mardirossian, M, Perebaskine, N, Benincasa, M, Gambato, S, Hofmann, S, Huter, P, Muller, C, Hilpert, K, Innis, C.A, Tossi, A, Wilson, D.N.
Deposit date:2018-01-24
Release date:2018-03-28
Last modified:2024-04-24
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:The Dolphin Proline-Rich Antimicrobial Peptide Tur1A Inhibits Protein Synthesis by Targeting the Bacterial Ribosome.
Cell Chem Biol, 25, 2018
6CAE
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BU of 6cae by Molmil
Crystal structure of the Thermus thermophilus 70S ribosome in complex with NOSO-95179 antibiotic and bound to mRNA and A-, P- and E-site tRNAs at 2.6A resolution
Descriptor: 16S Ribosomal RNA, 23S Ribosomal RNA, 30S ribosomal protein S10, ...
Authors:Pantel, L, Florin, T, Dobosz-Bartoszek, M, Racine, E, Sarciaux, M, Serri, M, Houard, J, Campagne, J.M, Marcia de Figueiredo, R, Midrier, C, Gaudriault, S, Givaudan, A, Lanois, A, Forst, S, Aumelas, A, Cotteaux-Lautard, C, Bolla, J.M, Vingsbo Lundberg, C, Huseby, D, Hughes, D, Villain-Guillot, P, Mankin, A.S, Polikanov, Y.S, Gualtieri, M.
Deposit date:2018-01-30
Release date:2018-04-18
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Odilorhabdins, Antibacterial Agents that Cause Miscoding by Binding at a New Ribosomal Site.
Mol. Cell, 70, 2018
4V6F
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BU of 4v6f by Molmil
Elongation complex of the 70S ribosome with three tRNAs and mRNA.
Descriptor: 16S ribosomal RNA, 23S RIBOSOMAL RNA, 23S RRNA, ...
Authors:Jenner, L.B, Yusupova, G, Yusupov, M.
Deposit date:2009-07-09
Release date:2014-07-09
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Structural aspects of messenger RNA reading frame maintenance by the ribosome.
Nat.Struct.Mol.Biol., 17, 2010
5Y6P
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BU of 5y6p by Molmil
Structure of the phycobilisome from the red alga Griffithsia pacifica
Descriptor: ApcD, ApcF, LC, ...
Authors:Zhang, J, Ma, J.F, Liu, D.S, Sun, S, Sui, S.F.
Deposit date:2017-08-13
Release date:2017-11-15
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Structure of phycobilisome from the red alga Griffithsia pacifica
Nature, 551, 2017
2AC5
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BU of 2ac5 by Molmil
Structure of human Mnk2 Kinase Domain mutant D228G
Descriptor: MAP kinase-interacting serine/threonine kinase 2, ZINC ION
Authors:Jauch, R, Wahl, M.C, Jakel, S, Schreiter, K, Aicher, B, Jackle, H.
Deposit date:2005-07-18
Release date:2005-10-04
Last modified:2024-05-29
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Crystal structures of the Mnk2 kinase domain reveal an inhibitory conformation and a zinc binding site.
Structure, 13, 2005
8B3Q
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BU of 8b3q by Molmil
CryoEM structure of the central filamentous region of the f1 filamentous bacteriophage, consisting of the major capsid protein pVIII
Descriptor: Capsid protein G8P
Authors:Conners, R, McLaren, M, Gold, V.A.M.
Deposit date:2022-09-16
Release date:2023-05-24
Last modified:2024-07-24
Method:ELECTRON MICROSCOPY (2.58 Å)
Cite:Cryo-electron microscopy of the f1 filamentous phage reveals insights into viral infection and assembly.
Nat Commun, 14, 2023
8UD8
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BU of 8ud8 by Molmil
Crystal structure of the A2503-C2,C8-dimethylated Thermus thermophilus 70S ribosome in complex with cresomycin, mRNA, deacylated A-site tRNAphe, aminoacylated P-site fMet-tRNAmet, and deacylated E-site tRNAphe at 2.70A resolution
Descriptor: (4S,5aS,8S,8aR)-4-(2-methylpropyl)-N-[(1R,5Z,7R,8R,9R,10R,11S,12R)-10,11,12-trihydroxy-7-methyl-13-oxa-2-thiabicyclo[7.3.1]tridec-5-en-8-yl]octahydro-2H-oxepino[2,3-c]pyrrole-8-carboxamide (non-preferred name), 16S Ribosomal RNA, 23S Ribosomal RNA, ...
Authors:Aleksandrova, E.V, Syroegin, E.A, Wu, K.J.Y, Tresco, B.I.C, Ramkissoon, A, See, D.N.Y, Liow, P, Dittemore, G.A, Yu, M, Testolin, G, Mitcheltree, M.J, Liu, R.Y, Svetlov, M.S, Myers, A.G, Polikanov, Y.S.
Deposit date:2023-09-28
Release date:2024-02-21
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:An antibiotic preorganized for ribosomal binding overcomes antimicrobial resistance.
Science, 383, 2024
5WVD
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BU of 5wvd by Molmil
Structure of Mnk1 in complex with DS12881479
Descriptor: 1-methyl-N-(5-phenyl-1,3-thiazol-2-yl)piperidine-4-carboxamide, MAP kinase interacting serine/threonine kinase 1, SULFATE ION
Authors:Matsui, Y, Hanzawa, H.
Deposit date:2016-12-24
Release date:2018-01-03
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (3 Å)
Cite:A novel inhibitor stabilizes the inactive conformation of MAPK-interacting kinase 1.
Acta Crystallogr F Struct Biol Commun, 74, 2018
5F8K
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BU of 5f8k by Molmil
Crystal structure of the Bac7(1-16) antimicrobial peptide bound to the Thermus thermophilus 70S ribosome
Descriptor: 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ...
Authors:Seefeldt, A.C, Graf, M, Perebaskine, N, Nguyen, F, Arenz, S, Mardirossian, M, Scocchi, M, Wilson, D.N, Innis, C.A.
Deposit date:2015-12-09
Release date:2016-02-03
Last modified:2024-04-24
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structure of the mammalian antimicrobial peptide Bac7(1-16) bound within the exit tunnel of a bacterial ribosome.
Nucleic Acids Res., 44, 2016
5J4C
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BU of 5j4c by Molmil
Crystal structure of the Thermus thermophilus 70S ribosome in complex with cisplatin (soaked) and bound to mRNA and A-, P- and E-site tRNAs at 2.8A resolution
Descriptor: 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ...
Authors:Melnikov, S.V, Soll, D, Steitz, T.A, Polikanov, Y.S.
Deposit date:2016-03-31
Release date:2016-04-27
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Insights into RNA binding by the anticancer drug cisplatin from the crystal structure of cisplatin-modified ribosome.
Nucleic Acids Res., 44, 2016
4V9Q
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BU of 4v9q by Molmil
Crystal Structure of Blasticidin S Bound to Thermus Thermophilus 70S Ribosome.
Descriptor: 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ...
Authors:Svidritskiy, E, Ling, C, Ermolenko, D.N, Korostelev, A.A.
Deposit date:2013-06-12
Release date:2014-07-09
Last modified:2019-07-17
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:Blasticidin S inhibits translation by trapping deformed tRNA on the ribosome.
Proc.Natl.Acad.Sci.USA, 110, 2013
4V88
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BU of 4v88 by Molmil
The structure of the eukaryotic ribosome at 3.0 A resolution.
Descriptor: 18S RIBOSOMAL RNA, 18S rRNA, 25S rRNA, ...
Authors:Ben-Shem, A, Garreau de Loubresse, N, Melnikov, S, Jenner, L, Yusupova, G, Yusupov, M.
Deposit date:2011-10-11
Release date:2014-07-09
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (3 Å)
Cite:The structure of the eukaryotic ribosome at 3.0 angstrom resolution.
Science, 334, 2011

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