2AC5

Structure of human Mnk2 Kinase Domain mutant D228G

Summary for 2AC5

• Entry DOI: 10.2210/pdb2ac5/pdb
• Related: 2AC3
• Descriptor: MAP kinase-interacting serine/threonine kinase 2, ZINC ION (3 entities in total)
• Functional Keywords: dfg motif, transferase
• Biological source: Homo sapiens (human)
• Cellular location: Isoform 2: Nucleus, PML body. Isoform 1: Cytoplasm: Q9HBH9
• Total number of polymer chains: 1
• Total formula weight: 35669.87

Authors

Jauch, R.,Wahl, M.C.,Jakel, S.,Schreiter, K.,Aicher, B.,Jackle, H. (deposition date: 2005-07-18, release date: 2005-10-04, Last modification date: 2021-11-10)

• Primary citation: Jauch, R.,Jakel, S.,Netter, C.,Schreiter, K.,Aicher, B.,Jackle, H.,Wahl, M.C.; Crystal structures of the Mnk2 kinase domain reveal an inhibitory conformation and a zinc binding site.; Structure, 13:1559-1568, 2005; PubMed: 16216586; DOI: 10.1016/j.str.2005.07.013

Experimental method

X-RAY DIFFRACTION (3.2 Å)