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2H5K
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Crystal Structure of Complex Between the Domain-Swapped Dimeric Grb2 SH2 Domain and Shc-Derived Ligand, Ac-NH-pTyr-Val-Asn-NH2
Descriptor: CACODYLATE ION, Growth factor receptor-bound protein 2, Shc-Derived Ligand
Authors:Benfield, A.P, Whiddon, B.B, Martin, S.F.
Deposit date:2006-05-26
Release date:2006-08-15
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (3.25 Å)
Cite:Structural and energetic aspects of Grb2-SH2 domain-swapping.
Arch.Biochem.Biophys., 462, 2007
2KK6
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BU of 2kk6 by Molmil
Solution structure of sh2 domain of proto-oncogene tyrosine-protein kinase fer from homo sapiens, northeast structural genomics consortium (nesg) target hr3461d
Descriptor: Proto-oncogene tyrosine-protein kinase FER
Authors:Tang, Y, Wang, D, Nwosu, C, Owens, L, Xiao, R, Liu, J, Baran, M.C, Swapna, G, Acton, T.B, Rost, B, Montelione, G.T, Northeast Structural Genomics Consortium (NESG)
Deposit date:2009-06-15
Release date:2009-08-11
Last modified:2024-05-01
Method:SOLUTION NMR
Cite:Solution structure of sh2 domain of proto-oncogene tyrosine-protein kinase fer from homo sapiens, northeast structural genomics consortium (nesg) target hr3461d
To be Published
2KNO
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BU of 2kno by Molmil
NMR Solution Structure of SH2 Domain of the Human Tensin Like C1 Domain Containing Phosphatase (TENC1)
Descriptor: Tensin-like C1 domain-containing phosphatase
Authors:Chen, L, Feng, R, Liu, C, Zhu, G.
Deposit date:2009-08-27
Release date:2010-09-01
Last modified:2024-05-01
Method:SOLUTION NMR
Cite:NMR Solution Structure of SH2 Domain of the Human Tensin Like C1 Domain Containing Phosphatase (TENC1)
To be Published
1A1A
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BU of 1a1a by Molmil
C-SRC (SH2 DOMAIN WITH C188A MUTATION) COMPLEXED WITH ACE-FORMYL PHOSPHOTYR-GLU-(N,N-DIPENTYL AMINE)
Descriptor: ACE-FORMYL PHOSPHOTYR-GLU-(N,N-DIPENTYL AMINE), C-SRC TYROSINE KINASE
Authors:Shewchuk, L, Jordan, S.
Deposit date:1997-12-10
Release date:1998-04-08
Last modified:2023-08-02
Method:X-RAY DIFFRACTION (2 Å)
Cite:Peptide ligands of pp60(c-src) SH2 domains: a thermodynamic and structural study.
Biochemistry, 36, 1997
1A08
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BU of 1a08 by Molmil
C-SRC (SH2 DOMAIN) COMPLEXED WITH ACE-DIFLUORO PHOSPHOTYR-GLU-(N,N-DIPENTYL AMINE)
Descriptor: ACE-DIFLUORO PHOSPHOTYR-GLU-(N,N-DIPENTYL AMINE), C-SRC TYROSINE KINASE
Authors:Shewchuk, L, Jordan, S.
Deposit date:1997-12-09
Release date:1998-04-08
Last modified:2023-08-02
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Peptide ligands of pp60(c-src) SH2 domains: a thermodynamic and structural study.
Biochemistry, 36, 1997
1A09
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BU of 1a09 by Molmil
C-src (SH2 domain) complexed with ace-formyl phosphotyr-glu-(n,n-dipentyl amine)
Descriptor: ACE-FORMYL PHOSPHOTYR-GLU-(N,N-DIPENTYL AMINE), C-SRC TYROSINE KINASE
Authors:Shewchuk, L, Jordan, S.
Deposit date:1997-12-10
Release date:1998-04-08
Last modified:2023-08-02
Method:X-RAY DIFFRACTION (2 Å)
Cite:Peptide ligands of pp60(c-src) SH2 domains: a thermodynamic and structural study.
Biochemistry, 36, 1997
1A1E
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BU of 1a1e by Molmil
C-SRC (SH2 DOMAIN) COMPLEXED WITH ACE-PHOSPHOTYR-GLU-(3-BUTYLPIPERIDINE)
Descriptor: ACE-PHOSPHOTYR-GLU-(3-BUTYLPIPERIDINE), C-SRC TYROSINE KINASE
Authors:Shewchuk, L, Jordan, S.
Deposit date:1997-12-10
Release date:1998-04-08
Last modified:2023-08-02
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Peptide ligands of pp60(c-src) SH2 domains: a thermodynamic and structural study.
Biochemistry, 36, 1997
1A1B
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C-SRC (SH2 DOMAIN) COMPLEXED WITH ACE-PHOSPHOTYR-GLU-(N,N-DIPENTYL AMINE)
Descriptor: ACE-PHOSPHOTYR-GLU-(N,N-DIPENTYL AMINE), C-SRC TYROSINE KINASE
Authors:Shewchuk, L, Jordan, S.
Deposit date:1997-12-10
Release date:1998-04-08
Last modified:2023-08-02
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Peptide ligands of pp60(c-src) SH2 domains: a thermodynamic and structural study.
Biochemistry, 36, 1997
1A1C
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BU of 1a1c by Molmil
C-SRC (SH2 DOMAIN) COMPLEXED WITH ACE-PHOSPHOTYR-GLU-(N-ME(-(CH2)3-CYCLOPENTYL))
Descriptor: ACE-PHOSPHOTYR-GLU-(N-ME(-(CH2)3-CYCLOPENTYL)), C-SRC TYROSINE KINASE
Authors:Shewchuk, L, Jordan, S.
Deposit date:1997-12-10
Release date:1998-04-08
Last modified:2023-08-02
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Peptide ligands of pp60(c-src) SH2 domains: a thermodynamic and structural study.
Biochemistry, 36, 1997
1A07
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BU of 1a07 by Molmil
C-SRC (SH2 DOMAIN) COMPLEXED WITH ACE-MALONYL TYR-GLU-(N,N-DIPENTYL AMINE)
Descriptor: ACE-MALONYL TYR-GLU-(N,N-DIPENTYL AMINE), C-SRC TYROSINE KINASE
Authors:Shewchuk, L, Jordan, S.
Deposit date:1997-12-09
Release date:1998-04-08
Last modified:2023-08-02
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Peptide ligands of pp60(c-src) SH2 domains: a thermodynamic and structural study.
Biochemistry, 36, 1997
1AB2
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BU of 1ab2 by Molmil
THREE-DIMENSIONAL SOLUTION STRUCTURE OF THE SRC HOMOLOGY 2 DOMAIN OF C-ABL
Descriptor: C-ABL TYROSINE KINASE SH2 DOMAIN
Authors:Overduin, M, Rios, C.B, Mayer, B.J, Baltimore, D, Cowburn, D.
Deposit date:1993-07-19
Release date:1994-01-31
Last modified:2024-05-22
Method:SOLUTION NMR
Cite:Three-dimensional solution structure of the src homology 2 domain of c-abl.
Cell(Cambridge,Mass.), 70, 1992
1AYD
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BU of 1ayd by Molmil
CRYSTAL STRUCTURES OF PEPTIDE COMPLEXES OF THE AMINO-TERMINAL SH2 DOMAIN OF THE SYP TYROSINE PHOSPHATASE
Descriptor: PROTEIN-TYROSINE PHOSPHATASE SYP (N-TERMINAL SH2 DOMAIN)
Authors:Lee, C.-H, Kuriyan, J.
Deposit date:1994-05-15
Release date:1994-08-31
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structures of peptide complexes of the amino-terminal SH2 domain of the Syp tyrosine phosphatase.
Structure, 2, 1994
1AYC
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BU of 1ayc by Molmil
CRYSTAL STRUCTURES OF PEPTIDE COMPLEXES OF THE AMINO-TERMINAL SH2 DOMAIN OF THE SYP TYROSINE PHOSPHATASE
Descriptor: PEPTIDE PDGFR-740, PROTEIN-TYROSINE PHOSPHATASE SYP (N-TERMINAL SH2 DOMAIN)
Authors:Lee, C.-H, Kuriyan, J.
Deposit date:1994-05-15
Release date:1994-08-31
Last modified:2024-06-05
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structures of peptide complexes of the amino-terminal SH2 domain of the Syp tyrosine phosphatase.
Structure, 2, 1994
1BHF
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BU of 1bhf by Molmil
P56LCK SH2 DOMAIN INHIBITOR COMPLEX
Descriptor: INHIBITOR ACE-IPA-GLU-GLU-ILE, T-LYMPHOCYTE-SPECIFIC PROTEIN TYROSINE KINASE P56LCK
Authors:Tong, L, Warren, T.C, Lukas, S, Schembri-King, J, Betageri, R, Proudfoot, J.R, Jakes, S.
Deposit date:1998-06-08
Release date:1998-10-21
Last modified:2024-06-05
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Carboxymethyl-phenylalanine as a replacement for phosphotyrosine in SH2 domain binding.
J.Biol.Chem., 273, 1998
1AYA
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BU of 1aya by Molmil
CRYSTAL STRUCTURES OF PEPTIDE COMPLEXES OF THE AMINO-TERMINAL SH2 DOMAIN OF THE SYP TYROSINE PHOSPHATASE
Descriptor: PEPTIDE PDGFR-1009, PROTEIN-TYROSINE PHOSPHATASE SYP (N-TERMINAL SH2 DOMAIN)
Authors:Lee, C.-H, Kuriyan, J.
Deposit date:1994-05-15
Release date:1994-08-31
Last modified:2024-06-05
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Crystal structures of peptide complexes of the amino-terminal SH2 domain of the Syp tyrosine phosphatase.
Structure, 2, 1994
1BFJ
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BU of 1bfj by Molmil
SOLUTION STRUCTURE OF THE C-TERMINAL SH2 DOMAIN OF THE P85ALPHA REGULATORY SUBUNIT OF PHOSPHOINOSITIDE 3-KINASE, NMR, MINIMIZED AVERAGE STRUCTURE
Descriptor: P85 ALPHA
Authors:Siegal, G, Davis, B, Kristensen, S.M, Sankar, A, Linacre, J, Stein, R.C, Panayotou, G, Waterfield, M.D, Driscoll, P.C.
Deposit date:1997-11-18
Release date:1998-02-25
Last modified:2024-05-22
Method:SOLUTION NMR
Cite:Solution structure of the C-terminal SH2 domain of the p85 alpha regulatory subunit of phosphoinositide 3-kinase.
J.Mol.Biol., 276, 1998
1BHH
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BU of 1bhh by Molmil
FREE P56LCK SH2 DOMAIN
Descriptor: P56 LCK TYROSINE KINASE SH2 DOMAIN, T-LYMPHOCYTE-SPECIFIC PROTEIN TYROSINE KINASE P56LCK
Authors:Tong, L, Warren, T.C, Lukas, S, Schembri-King, J, Betageri, R, Proudfoot, J.R, Jakes, S.
Deposit date:1998-06-08
Release date:1998-10-21
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Carboxymethyl-phenylalanine as a replacement for phosphotyrosine in SH2 domain binding.
J.Biol.Chem., 273, 1998
1AOU
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NMR STRUCTURE OF THE FYN SH2 DOMAIN COMPLEXED WITH A PHOSPHOTYROSYL PEPTIDE, 22 STRUCTURES
Descriptor: FYN PROTEIN-TYROSINE KINASE, PHOSPHOTYROSYL PEPTIDE
Authors:Mulhern, T.D, Shaw, G.L, Morton, C.J, Day, A.J, Campbell, I.D.
Deposit date:1997-07-10
Release date:1998-01-14
Last modified:2021-11-03
Method:SOLUTION NMR
Cite:The SH2 domain from the tyrosine kinase Fyn in complex with a phosphotyrosyl peptide reveals insights into domain stability and binding specificity.
Structure, 5, 1997
1BFI
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BU of 1bfi by Molmil
SOLUTION STRUCTURE OF THE C-TERMINAL SH2 DOMAIN OF THE P85ALPHA REGULATORY SUBUNIT OF PHOSPHOINOSITIDE 3-KINASE, NMR, 30 STRUCTURES
Descriptor: P85 ALPHA
Authors:Siegal, G, Davis, B, Kristensen, S.M, Sankar, A, Linacre, J, Stein, R.C, Panayotou, G, Waterfield, M.D, Driscoll, P.C.
Deposit date:1997-11-18
Release date:1998-02-25
Last modified:2024-05-22
Method:SOLUTION NMR
Cite:Solution structure of the C-terminal SH2 domain of the p85 alpha regulatory subunit of phosphoinositide 3-kinase.
J.Mol.Biol., 276, 1998
1AYB
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BU of 1ayb by Molmil
CRYSTAL STRUCTURES OF PEPTIDE COMPLEXES OF THE AMINO-TERMINAL SH2 DOMAIN OF THE SYP TYROSINE PHOSPHATASE
Descriptor: PEPTIDE IRS-1-895, PROTEIN-TYROSINE PHOSPHATASE SYP (N-TERMINAL SH2 DOMAIN)
Authors:Lee, C.-H, Kuriyan, J.
Deposit date:1994-05-15
Release date:1994-08-31
Last modified:2024-06-05
Method:X-RAY DIFFRACTION (3 Å)
Cite:Crystal structures of peptide complexes of the amino-terminal SH2 domain of the Syp tyrosine phosphatase.
Structure, 2, 1994
1BKL
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BU of 1bkl by Molmil
SELF-ASSOCIATED APO SRC SH2 DOMAIN
Descriptor: PP60 V-SRC TYROSINE KINASE TRANSFORMING PROTEIN
Authors:Holland, D.R, Rubin, J.R.
Deposit date:1997-05-02
Release date:1997-07-23
Last modified:2024-05-22
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Novel Pp60Src Sh2 Domain Crystal Structures: A 2.0 Angstrom Co-Crystal Structure of a D-Amino Acid Substituted Phosphopeptide Complex and a 2.1 Angstrom Apo Structure Displaying Self-Association
To be Published
1BLJ
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BU of 1blj by Molmil
NMR ENSEMBLE OF BLK SH2 DOMAIN, 20 STRUCTURES
Descriptor: P55 BLK PROTEIN TYROSINE KINASE
Authors:Metzler, W.J, Leiting, B, Pryor, K, Mueller, L, Farmer II, B.T.
Deposit date:1996-03-26
Release date:1997-03-12
Last modified:2024-05-22
Method:SOLUTION NMR
Cite:The three-dimensional solution structure of the SH2 domain from p55blk kinase.
Biochemistry, 35, 1996
1BMB
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GRB2-SH2 DOMAIN IN COMPLEX WITH KPFY*VNVEF (PKF270-974)
Descriptor: PROTEIN (GROWTH FACTOR RECEPTOR BOUND PROTEIN 2), PROTEIN (PKF270-974)
Authors:Rondeau, J.M, Zurini, M.
Deposit date:1998-07-23
Release date:1998-07-29
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural and conformational requirements for high-affinity binding to the SH2 domain of Grb2(1).
J.Med.Chem., 42, 1999
1BM2
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GRB2-SH2 DOMAIN IN COMPLEX WITH CYCLO-[N-ALPHA-ACETYL-L-THI ALYSYL-O-PHOSPHOTYROSYL-VALYL-ASPARAGYL-VALYL-PROLYL] (PKF273-791)
Descriptor: PROTEIN (GROWTH FACTOR RECEPTOR BOUND PROTEIN 2), PROTEIN (PKF273-791)
Authors:Rondeau, J.M, Zurini, M.
Deposit date:1998-07-27
Release date:1998-08-05
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural and conformational requirements for high-affinity binding to the SH2 domain of Grb2(1).
J.Med.Chem., 42, 1999
1AOT
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BU of 1aot by Molmil
NMR STRUCTURE OF THE FYN SH2 DOMAIN COMPLEXED WITH A PHOSPHOTYROSYL PEPTIDE, MINIMIZED AVERAGE STRUCTURE
Descriptor: FYN PROTEIN-TYROSINE KINASE, PHOSPHOTYROSYL PEPTIDE
Authors:Mulhern, T.D, Shaw, G.L, Morton, C.J, Day, A.J, Campbell, I.D.
Deposit date:1997-07-10
Release date:1998-01-14
Last modified:2021-11-03
Method:SOLUTION NMR
Cite:The SH2 domain from the tyrosine kinase Fyn in complex with a phosphotyrosyl peptide reveals insights into domain stability and binding specificity.
Structure, 5, 1997

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