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8BWE
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BU of 8bwe by Molmil
Small molecule stabilizer for 14-3-3/ChREBP (Cmd 43)
Descriptor: 14-3-3 protein sigma, Carbohydrate-responsive element-binding protein, MAGNESIUM ION, ...
Authors:Visser, E.J, Pennings, M.A.M, Ottmann, C.
Deposit date:2022-12-06
Release date:2024-05-01
Method:X-RAY DIFFRACTION (2 Å)
Cite:Molecular glues of the regulatory ChREBP/14-3-3 complex protect beta cells from glucolipotoxicity.
Biorxiv, 2024
8C3C
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BU of 8c3c by Molmil
14-3-3 sigma with Pin1 binding site pS72 and bound Fusicoccin A
Descriptor: 14-3-3 protein sigma, FUSICOCCIN, MAGNESIUM ION, ...
Authors:Verhoef, C.J, Cossar, P.
Deposit date:2022-12-23
Release date:2023-06-14
Last modified:2023-07-05
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Tracking the mechanism of covalent molecular glue stabilization using native mass spectrometry.
Chem Sci, 14, 2023
8C2G
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BU of 8c2g by Molmil
14-3-3 sigma with Pin1 binding site pS72 and covalently bound CV1040
Descriptor: 14-3-3 protein sigma, 2-iodanyl-4-(2-phenylimidazol-1-yl)benzaldehyde, MAGNESIUM ION, ...
Authors:Verhoef, C.J, Cossar, P.
Deposit date:2022-12-22
Release date:2023-06-14
Last modified:2023-07-05
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Tracking the mechanism of covalent molecular glue stabilization using native mass spectrometry.
Chem Sci, 14, 2023
6BYJ
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BU of 6byj by Molmil
Structure of human 14-3-3 gamma bound to O-GlcNAc peptide
Descriptor: 14-3-3 protein gamma, 2-acetamido-2-deoxy-beta-D-glucopyranose, TSTTATPPVSQASSTTTSTW O-GlcNac peptide
Authors:Schumacher, M.A.
Deposit date:2017-12-20
Release date:2018-05-09
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structural basis of O-GlcNAc recognition by mammalian 14-3-3 proteins.
Proc.Natl.Acad.Sci.USA, 115, 2018
6BYL
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BU of 6byl by Molmil
Structure of 14-3-3 gamma bound to O-GlcNAcylated thr peptide
Descriptor: 14-3-3 protein gamma, 2-acetamido-2-deoxy-beta-D-glucopyranose, TSASTTVPVTTATTTTTSTW O-GlcNac peptide
Authors:Schumacher, M.A.
Deposit date:2017-12-20
Release date:2018-05-09
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (3.35 Å)
Cite:Structural basis of O-GlcNAc recognition by mammalian 14-3-3 proteins.
Proc.Natl.Acad.Sci.USA, 115, 2018
5D2D
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BU of 5d2d by Molmil
Crystal structure of human 14-3-3 zeta in complex with CFTR R-domain peptide pS753-pS768
Descriptor: 14-3-3 protein zeta/delta, CHLORIDE ION, Cystic fibrosis transmembrane conductance regulator, ...
Authors:Stevers, L.M, Leysen, S.F.R, Ottmann, C.
Deposit date:2015-08-05
Release date:2016-03-16
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Characterization and small-molecule stabilization of the multisite tandem binding between 14-3-3 and the R domain of CFTR.
Proc.Natl.Acad.Sci.USA, 113, 2016
6BQT
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BU of 6bqt by Molmil
Complex of 14-3-3 theta with an IRSp53 peptide doubly-phosphorylated at T340 and T360
Descriptor: 1,2-ETHANEDIOL, 14-3-3 protein theta, 2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL, ...
Authors:Kast, D.J, Dominguez, R.
Deposit date:2017-11-28
Release date:2018-12-05
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Mechanism of IRSp53 inhibition by 14-3-3.
Nat Commun, 10, 2019
6BYK
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BU of 6byk by Molmil
Structure of 14-3-3 beta/alpha bound to O-ClcNAc peptide
Descriptor: 14-3-3 protein beta/alpha, 2-acetamido-2-deoxy-beta-D-glucopyranose, ATPPVSQASSTT O-GlcNac peptide
Authors:Schumacher, M.A.
Deposit date:2017-12-20
Release date:2018-05-09
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structural basis of O-GlcNAc recognition by mammalian 14-3-3 proteins.
Proc.Natl.Acad.Sci.USA, 115, 2018
6BZD
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BU of 6bzd by Molmil
Structure of 14-3-3 gamma R57E mutant bound to GlcNAcylated peptide
Descriptor: 14-3-3 protein gamma, 2-acetamido-2-deoxy-beta-D-glucopyranose, GlcNAcylated peptide
Authors:Schumacher, M.A.
Deposit date:2017-12-22
Release date:2018-05-09
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.67 Å)
Cite:Structural basis of O-GlcNAc recognition by mammalian 14-3-3 proteins.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6EF5
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BU of 6ef5 by Molmil
14-3-3 with peptide
Descriptor: 14-3-3 protein zeta/delta, ARG-SER-LEU-SEP-ALA-PRO-GLY, LYS-LEU-SEP-LEU-GLN
Authors:Dhagat, U, Langendorf, C.G, Parker, M.W.P, Oakhill, J.S, Scott, J.W.
Deposit date:2018-08-16
Release date:2019-10-30
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.44 Å)
Cite:14-3-3 with peptide
To Be Published
5EXA
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BU of 5exa by Molmil
Small-molecule stabilization of the 14-3-3/Gab2 PPI interface
Descriptor: 14-3-3 protein zeta/delta, BENZOIC ACID, Fusicoccin A-THF derivative, ...
Authors:Bier, D, Ottmann, C.
Deposit date:2015-11-23
Release date:2016-05-04
Last modified:2018-12-19
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Small-Molecule Stabilization of the 14-3-3/Gab2 Protein-Protein Interaction (PPI) Interface.
Chemmedchem, 11, 2016
5EWZ
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BU of 5ewz by Molmil
Small-molecule stabilization of the 14-3-3/Gab2 PPI interface
Descriptor: 14-3-3 protein zeta/delta, BENZOIC ACID, GRB2-associated-binding protein 2
Authors:Bier, D, Ottmann, C.
Deposit date:2015-11-23
Release date:2016-05-04
Last modified:2018-12-19
Method:X-RAY DIFFRACTION (2.34 Å)
Cite:Small-Molecule Stabilization of the 14-3-3/Gab2 Protein-Protein Interaction (PPI) Interface.
Chemmedchem, 11, 2016
5D3F
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BU of 5d3f by Molmil
Crystal structure of human 14-3-3 zeta in complex with CFTR R-domain peptide pS753-pS768 and stabilizer fusicoccin-A
Descriptor: 14-3-3 protein zeta/delta, Cystic fibrosis transmembrane conductance regulator, FUSICOCCIN
Authors:Stevers, L.M, Leysen, S.F.R, Ottmann, C.
Deposit date:2015-08-06
Release date:2016-03-16
Last modified:2019-03-13
Method:X-RAY DIFFRACTION (2.74 Å)
Cite:Characterization and small-molecule stabilization of the multisite tandem binding between 14-3-3 and the R domain of CFTR.
Proc.Natl.Acad.Sci.USA, 113, 2016
5F74
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BU of 5f74 by Molmil
Crystal structure of ChREBP:14-3-3 complex bound with AMP
Descriptor: 14-3-3 protein beta/alpha, ADENOSINE MONOPHOSPHATE, Carbohydrate-responsive element-binding protein
Authors:Jung, H, Uyeda, K.
Deposit date:2015-12-07
Release date:2016-03-23
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Metabolite Regulation of Nuclear Localization of Carbohydrate-response Element-binding Protein (ChREBP): ROLE OF AMP AS AN ALLOSTERIC INHIBITOR.
J.Biol.Chem., 291, 2016
5D3E
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BU of 5d3e by Molmil
Crystal structure of human 14-3-3 gamma in complex with CFTR R-domain peptide pS768-pS795
Descriptor: 14-3-3 protein gamma, Cystic fibrosis transmembrane conductance regulator
Authors:Stevers, L.M, Leysen, S.F.R, Ottmann, C.
Deposit date:2015-08-06
Release date:2016-03-16
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Characterization and small-molecule stabilization of the multisite tandem binding between 14-3-3 and the R domain of CFTR.
Proc.Natl.Acad.Sci.USA, 113, 2016
6EJL
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BU of 6ejl by Molmil
Structure of 14-3-3 zeta in complex with ASK1 14-3-3 binding motif
Descriptor: 14-3-3 protein zeta/delta, Mitogen-activated protein kinase kinase kinase 5
Authors:Petrvalska, O, Lentini Santo, D, Obsilova, V, Obsil, T.
Deposit date:2017-09-21
Release date:2017-11-08
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.382 Å)
Cite:Crystal structure of 14-3-3 zeta in complex with ASK1 14-3-3 binding motif
To Be Published
5BY9
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BU of 5by9 by Molmil
The crystal structure of polyglycilated 14-3-3 protein from Giardia intestinalis
Descriptor: 14-3-3 protein
Authors:Fiorillo, A, Ilari, A, Lalle, M.
Deposit date:2015-06-10
Release date:2016-04-27
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (4 Å)
Cite:Molecular Dynamics Simulations and Structural Analysis of Giardia duodenalis 14-3-3 Protein-Protein Interactions.
J.Chem.Inf.Model., 55, 2015
5XY9
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BU of 5xy9 by Molmil
Structure of the MST4 and 14-3-3 complex
Descriptor: 14-3-3 protein zeta/delta, 2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL, GLYCEROL, ...
Authors:Shi, Z.B, Zhou, Z.C.
Deposit date:2017-07-06
Release date:2018-07-11
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.303 Å)
Cite:Structure of the MST4 and 14-3-3 complex
To Be Published
8P1H
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BU of 8p1h by Molmil
Crystal structure of the chimera of human 14-3-3 zeta and phosphorylated cytoplasmic loop fragment of the alpha7 acetylcholine receptor
Descriptor: 1,2-ETHANEDIOL, AZIDE ION, BENZOIC ACID, ...
Authors:Boyko, K.M, Kapitonova, A.A, Tugaeva, K.V, Varfolomeeva, L.A, Lyukmanova, E.N, Sluchanko, N.N.
Deposit date:2023-05-12
Release date:2023-10-18
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Crystal structure reveals canonical recognition of the phosphorylated cytoplasmic loop of human alpha7 nicotinic acetylcholine receptor by 14-3-3 protein.
Biochem.Biophys.Res.Commun., 682, 2023
8P0D
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BU of 8p0d by Molmil
Human 14-3-3 sigma in complex with human MDM2 peptide
Descriptor: 14-3-3 protein sigma, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ...
Authors:Roversi, P, Ward, J, Doveston, R, Kwon, H, Romartinez Alonso, B.
Deposit date:2023-05-10
Release date:2024-02-21
Method:X-RAY DIFFRACTION (1.31 Å)
Cite:Characterizing the protein-protein interaction between MDM2 and 14-3-3 sigma ; proof of concept for small molecule stabilization.
J.Biol.Chem., 300, 2024
6A5Q
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BU of 6a5q by Molmil
Structure of 14-3-3 beta in complex with TFEB 14-3-3 binding motif
Descriptor: 14-3-3 protein beta/alpha, MALONIC ACID, TFEB pS211-peptide
Authors:Xu, Y, Ren, J.Q, Feng, W.
Deposit date:2018-06-25
Release date:2019-02-13
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2 Å)
Cite:YWHA/14-3-3 proteins recognize phosphorylated TFEB by a noncanonical mode for controlling TFEB cytoplasmic localization.
Autophagy, 15, 2019
6A5S
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BU of 6a5s by Molmil
Structure of 14-3-3 gamma in complex with TFEB 14-3-3 binding motif
Descriptor: 14-3-3 protein gamma, MAGNESIUM ION, SODIUM ION, ...
Authors:Xu, Y, Ren, J.Q, Feng, W.
Deposit date:2018-06-25
Release date:2019-02-13
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.099 Å)
Cite:YWHA/14-3-3 proteins recognize phosphorylated TFEB by a noncanonical mode for controlling TFEB cytoplasmic localization.
Autophagy, 15, 2019
8Q1S
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BU of 8q1s by Molmil
Pathogenic mutations of human phosphorylation sites affect protein-protein interactions
Descriptor: 1,2-ETHANEDIOL, 14-3-3 protein epsilon, BROMIDE ION, ...
Authors:Roske, Y, Daumke, O, Rrustemi, T, Selbach, M.
Deposit date:2023-08-01
Release date:2024-02-21
Last modified:2024-04-24
Method:X-RAY DIFFRACTION (3.23 Å)
Cite:Pathogenic mutations of human phosphorylation sites affect protein-protein interactions.
Nat Commun, 15, 2024
8QT5
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BU of 8qt5 by Molmil
Crystal structure of Arabidopsis thaliana 14-3-3 isoform lambda in complex with a phosphopeptide from the transcription factor BZR1.
Descriptor: 14-3-3-like protein G-BOX factor 14 lambda,Protein BRASSINAZOLE-RESISTANT 1, ACETATE ION
Authors:Hothorn, M, Obergfell, E.
Deposit date:2023-10-12
Release date:2023-10-25
Last modified:2024-06-05
Method:X-RAY DIFFRACTION (2.69 Å)
Cite:Mechanistic insights into the function of 14-3-3 proteins as negative regulators of brassinosteroid signaling in Arabidopsis.
Plant Cell.Physiol., 2024
8QTC
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BU of 8qtc by Molmil
Crystal structure of Arabidopsis thaliana 14-3-3 omega in complex with a phosphopeptide from the transcription factor BZR1.
Descriptor: 14-3-3-like protein GF14 omega, COBALT (II) ION, Protein BRASSINAZOLE-RESISTANT 1, ...
Authors:Hothorn, M, Obergfell, E.
Deposit date:2023-10-12
Release date:2023-11-15
Last modified:2024-06-05
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Mechanistic insights into the function of 14-3-3 proteins as negative regulators of brassinosteroid signaling in Arabidopsis.
Plant Cell.Physiol., 2024

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PDB entries from 2024-09-18

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