5D2D
Crystal structure of human 14-3-3 zeta in complex with CFTR R-domain peptide pS753-pS768
Summary for 5D2D
Entry DOI | 10.2210/pdb5d2d/pdb |
Related PRD ID | PRD_900003 |
Descriptor | 14-3-3 protein zeta/delta, Cystic fibrosis transmembrane conductance regulator, beta-D-fructofuranose-(2-1)-alpha-D-glucopyranose, ... (5 entities in total) |
Functional Keywords | protein-peptide complex, phosphorylation, tandem binding, peptide binding protein |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 3 |
Total formula weight | 56716.59 |
Authors | Stevers, L.M.,Leysen, S.F.R.,Ottmann, C. (deposition date: 2015-08-05, release date: 2016-03-16, Last modification date: 2020-07-29) |
Primary citation | Stevers, L.M.,Lam, C.V.,Leysen, S.F.,Meijer, F.A.,van Scheppingen, D.S.,de Vries, R.M.,Carlile, G.W.,Milroy, L.G.,Thomas, D.Y.,Brunsveld, L.,Ottmann, C. Characterization and small-molecule stabilization of the multisite tandem binding between 14-3-3 and the R domain of CFTR. Proc.Natl.Acad.Sci.USA, 113:E1152-E1161, 2016 Cited by PubMed: 26888287DOI: 10.1073/pnas.1516631113 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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