8P1H

Crystal structure of the chimera of human 14-3-3 zeta and phosphorylated cytoplasmic loop fragment of the alpha7 acetylcholine receptor

Summary for 8P1H

Entry DOI	10.2210/pdb8p1h/pdb
Descriptor	Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta,Neuronal acetylcholine receptor subunit alpha-7, 1,2-ETHANEDIOL, AZIDE ION, ... (6 entities in total)
Functional Keywords	14-3-3, acetylcholine receptor, protein binding, signaling protein
Biological source	Homo sapiens (human) More
Total number of polymer chains	2
Total formula weight	56235.12
Authors	Boyko, K.M.,Kapitonova, A.A.,Tugaeva, K.V.,Varfolomeeva, L.A.,Lyukmanova, E.N.,Sluchanko, N.N. (deposition date: 2023-05-12, release date: 2023-10-18)
Primary citation	Sluchanko, N.N.,Kapitonova, A.A.,Shulepko, M.A.,Kukushkin, I.D.,Kulbatskii, D.S.,Tugaeva, K.V.,Varfolomeeva, L.A.,Minyaev, M.E.,Boyko, K.M.,Popov, V.O.,Kirpichnikov, M.P.,Lyukmanova, E.N. Crystal structure reveals canonical recognition of the phosphorylated cytoplasmic loop of human alpha7 nicotinic acetylcholine receptor by 14-3-3 protein. Biochem.Biophys.Res.Commun., 682:91-96, 2023 Cited by PubMed: 37804592 DOI: 10.1016/j.bbrc.2023.09.086 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.95 Å)

Structure validation