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7E3X
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BU of 7e3x by Molmil
Crystal structure of SDR family NAD(P)-dependent oxidoreductase from exiguobacterium
Descriptor: NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, Oxidoreductase
Authors:Chen, L, Tang, J, Yuan, S, Zhang, F, Chen, S.
Deposit date:2021-02-09
Release date:2021-09-29
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.58 Å)
Cite:Structure-guided evolution of a ketoreductase forefficient and stereoselective bioreduction of bulkyalpha-aminobeta-keto esters
Catalysis Science And Technology, 2021
7E24
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BU of 7e24 by Molmil
Crystal structure of SDR family NAD(P)-dependent oxidoreductase from Exiguobacterium
Descriptor: NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, Oxidoreductase
Authors:Chen, L, Tang, J, Yuan, S.
Deposit date:2021-02-04
Release date:2021-09-29
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.7203 Å)
Cite:Structure-guided evolution of a ketoreductase forefficient and stereoselective bioreduction of bulkyalpha-aminobeta-keto esters
Catalysis Science And Technology, 2021
7E28
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BU of 7e28 by Molmil
Crystal structure of SDR family NAD(P)-dependent oxidoreductase from Exiguobacterium
Descriptor: Oxidoreductase
Authors:Chen, L, Tang, J, Yuan, S.
Deposit date:2021-02-05
Release date:2021-09-29
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.83 Å)
Cite:Structure-guided evolution of a ketoreductase forefficient and stereoselective bioreduction of bulkyalpha-aminobeta-keto esters
Catalysis Science And Technology, 2021
7E6O
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BU of 7e6o by Molmil
Crystal structure of polyol dehydrogenase from Paracoccus denitrificans
Descriptor: Short-chain dehydrogenase/reductase SDR
Authors:Sha, F, Zheng, Y.C.
Deposit date:2021-02-22
Release date:2022-03-02
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal structure of polyol dehydrogenase from Paracoccus denitrificans
To Be Published
2ET6
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BU of 2et6 by Molmil
(3R)-Hydroxyacyl-CoA Dehydrogenase Domain of Candida tropicalis Peroxisomal Multifunctional Enzyme Type 2
Descriptor: (3R)-hydroxyacyl-CoA dehydrogenase
Authors:Ylianttila, M.S, Hiltunen, J.K, Glumoff, T.
Deposit date:2005-10-27
Release date:2006-05-23
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.22 Å)
Cite:Crystal Structure of Yeast Peroxisomal Multifunctional Enzyme: Structural Basis for Substrate Specificity of (3R)-hydroxyacyl-CoA Dehydrogenase Units.
J.Mol.Biol., 358, 2006
2GDZ
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BU of 2gdz by Molmil
Crystal structure of 15-hydroxyprostaglandin dehydrogenase type1, complexed with NAD+
Descriptor: NAD+-dependent 15-hydroxyprostaglandin dehydrogenase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE
Authors:Pilka, E.S, Guo, K, Kavanagh, K, Von Delft, F, Arrowsmith, C, Weigelt, J, Edwards, A, Sundstrom, M, Oppermann, U, Structural Genomics Consortium (SGC)
Deposit date:2006-03-17
Release date:2006-04-04
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:High-Affinity Inhibitors of Human NAD-Dependent 15-Hydroxyprostaglandin Dehydrogenase: Mechanisms of Inhibition and Structure-Activity Relationships.
Plos One, 5, 2010
2O23
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BU of 2o23 by Molmil
The structure of wild-type human HADH2 (17beta-hydroxysteroid dehydrogenase type 10) bound to NAD+ at 1.2 A
Descriptor: GLYCEROL, HADH2 protein, NICOTINAMIDE-ADENINE-DINUCLEOTIDE
Authors:Kavanagh, K.L, Shafqat, N, Scholer, K, Debreczeni, J, Zschocke, J, von Delft, F, Weigelt, J, Arrowsmith, C, Sundstrom, M, Edwards, A, Oppermann, U, Structural Genomics Consortium (SGC)
Deposit date:2006-11-29
Release date:2006-12-12
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:The structure of wild-type human HADH2 (17beta-hydroxysteroid dehydrogenase type 10) bound to NAD+ at 1.2 A
To be Published
2NWQ
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Short chain dehydrogenase from Pseudomonas aeruginosa
Descriptor: Probable short-chain dehydrogenase, SULFATE ION
Authors:McGrath, T.E, Kimber, M.S, Beattie, B, Thambipillai, D, Dharamsi, A, Virag, C, Nethery-Brokx, K, Edwards, A.M, Pai, E.F, Chirgadze, N.Y.
Deposit date:2006-11-16
Release date:2006-11-28
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Short chain dehydrogenase from Pseudomonas aeruginosa
To be Published
2PFG
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BU of 2pfg by Molmil
Crystal structure of human CBR1 in complex with BiGF2.
Descriptor: (5R,10S)-5-{[(CARBOXYMETHYL)AMINO]CARBONYL}-7-OXO-3-THIA-1,6-DIAZABICYCLO[4.4.1]UNDECANE-10-CARBOXYLIC ACID, CHLORIDE ION, Carbonyl reductase [NADPH] 1, ...
Authors:Rauh, D, Bateman, R.L, Shokat, K.M.
Deposit date:2007-04-04
Release date:2007-09-25
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.54 Å)
Cite:Glutathione traps formaldehyde by formation of a bicyclo[4.4.1]undecane adduct.
Org.Biomol.Chem., 5, 2007
2Q2V
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BU of 2q2v by Molmil
Structure of D-3-Hydroxybutyrate Dehydrogenase from Pseudomonas putida
Descriptor: Beta-D-hydroxybutyrate dehydrogenase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE
Authors:Paithankar, K.S, Feller, C, Kuettner, E.B, Keim, A, Grunow, M, Strater, N.
Deposit date:2007-05-29
Release date:2007-10-30
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Cosubstrate-induced dynamics of D-3-hydroxybutyrate dehydrogenase from Pseudomonas putida.
Febs J., 274, 2007
2Q2Q
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BU of 2q2q by Molmil
Structure of D-3-Hydroxybutyrate Dehydrogenase from Pseudomonas putida
Descriptor: Beta-D-hydroxybutyrate dehydrogenase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE
Authors:Paithankar, K.S, Feller, C, Kuettner, E.B, Keim, A, Grunow, M, Strater, N.
Deposit date:2007-05-29
Release date:2007-10-30
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.02 Å)
Cite:Cosubstrate-induced dynamics of D-3-hydroxybutyrate dehydrogenase from Pseudomonas putida.
Febs J., 274, 2007
2Q2W
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BU of 2q2w by Molmil
Structure of D-3-Hydroxybutyrate Dehydrogenase from Pseudomonas putida
Descriptor: Beta-D-hydroxybutyrate dehydrogenase
Authors:Paithankar, K.S, Feller, C, Kuettner, E.B, Keim, A, Grunow, M, Strater, N.
Deposit date:2007-05-29
Release date:2007-10-30
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.12 Å)
Cite:Cosubstrate-induced dynamics of D-3-hydroxybutyrate dehydrogenase from Pseudomonas putida.
Febs J., 274, 2007
2QQ5
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BU of 2qq5 by Molmil
Crystal structure of human SDR family member 1
Descriptor: Dehydrogenase/reductase SDR family member 1
Authors:Pilka, E.S, Hozjan, V, Ugochukwu, E, von Delft, F, Sundstrom, M, Arrowsmith, C.H, Weigelt, J, Edwards, A, Oppermann, U, Structural Genomics Consortium (SGC)
Deposit date:2007-07-26
Release date:2007-08-07
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal structure of human SDR family member 1.
TO BE PUBLISHED
1QYX
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BU of 1qyx by Molmil
Crystal structure of human estrogenic 17beta-hydroxysteroid dehydrogenase complex with androstenedione and NADP
Descriptor: 4-ANDROSTENE-3-17-DIONE, Estradiol 17 beta-dehydrogenase 1, GLYCEROL, ...
Authors:Shi, R, Lin, S.X.
Deposit date:2003-09-12
Release date:2004-08-03
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (1.89 Å)
Cite:Cofactor hydrogen bonding onto the protein main chain is conserved in the short chain dehydrogenase/reductase family and contributes to nicotinamide orientation.
J.Biol.Chem., 279, 2004
1QYV
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BU of 1qyv by Molmil
Crystal structure of human estrogenic 17beta-hydroxysteroid dehydrogenase complex with NADP
Descriptor: Estradiol 17 beta-dehydrogenase 1, GLYCEROL, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Authors:Shi, R, Lin, S.X.
Deposit date:2003-09-12
Release date:2004-08-03
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (1.81 Å)
Cite:Cofactor hydrogen bonding onto the protein main chain is conserved in the short chain dehydrogenase/reductase family and contributes to nicotinamide orientation.
J.Biol.Chem., 279, 2004
1QYW
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BU of 1qyw by Molmil
Crystal structure of human estrogenic 17beta-hydroxysteroid dehydrogenase complex with androstanedione and NADP
Descriptor: 5ALPHA-ANDROSTAN-3,17-DIONE, Estradiol 17 beta-dehydrogenase 1, GLYCEROL, ...
Authors:Shi, R, Lin, S.X.
Deposit date:2003-09-12
Release date:2004-08-03
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (1.63 Å)
Cite:Cofactor hydrogen bonding onto the protein main chain is conserved in the short chain dehydrogenase/reductase family and contributes to nicotinamide orientation.
J.Biol.Chem., 279, 2004
2RBE
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BU of 2rbe by Molmil
The discovery of 2-anilinothiazolones as 11beta-HSD1 inhibitors
Descriptor: (5R)-2-[(2-fluorophenyl)amino]-5-(1-methylethyl)-1,3-thiazol-4(5H)-one, Corticosteroid 11-beta-dehydrogenase isozyme 1, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Authors:Zhang, J, Jordan, S.R, Li, V.
Deposit date:2007-09-18
Release date:2008-01-15
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:The discovery of 2-anilinothiazolones as 11beta-HSD1 inhibitors.
Bioorg.Med.Chem.Lett., 17, 2007
2RH4
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BU of 2rh4 by Molmil
Actinorhodin ketoreductase, actKR, with NADPH and Inhibitor Emodin
Descriptor: 3-METHYL-1,6,8-TRIHYDROXYANTHRAQUINONE, Actinorhodin Polyketide Ketoreductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Authors:Korman, T.P, Tsai, S.-C.
Deposit date:2007-10-05
Release date:2008-08-19
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Inhibition kinetics and emodin cocrystal structure of a type II polyketide ketoreductase
Biochemistry, 47, 2008
2RHC
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BU of 2rhc by Molmil
Actinorhodin ketordeuctase, actKR, with NADP+ and Inhibitor Emodin
Descriptor: 3-METHYL-1,6,8-TRIHYDROXYANTHRAQUINONE, Actinorhodin Polyketide Ketoreductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Authors:Korman, T.P, Tsai, S.-C.
Deposit date:2007-10-08
Release date:2008-08-19
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Inhibition kinetics and emodin cocrystal structure of a type II polyketide ketoreductase
Biochemistry, 47, 2008
2RHR
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BU of 2rhr by Molmil
P94L actinorhodin ketordeuctase mutant, with NADPH and Inhibitor Emodin
Descriptor: 3-METHYL-1,6,8-TRIHYDROXYANTHRAQUINONE, Actinorhodin Polyketide Ketoreductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Authors:Korman, T.P, Tsai, S.-C.
Deposit date:2007-10-09
Release date:2008-08-19
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Inhibition kinetics and emodin cocrystal structure of a type II polyketide ketoreductase
Biochemistry, 47, 2008
1SO8
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BU of 1so8 by Molmil
Abeta-bound human ABAD structure [also known as 3-hydroxyacyl-CoA dehydrogenase type II (Type II HADH), Endoplasmic reticulum-associated amyloid beta-peptide binding protein (ERAB)]
Descriptor: 3-hydroxyacyl-CoA dehydrogenase type II, CHLORIDE ION, SODIUM ION
Authors:Lustbader, J.W, Cirilli, M, Wu, H.
Deposit date:2004-03-13
Release date:2004-05-11
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:ABAD directly links Abeta to mitochondrial toxicity in Alzheimer's disease.
Science, 304, 2004
1SBY
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BU of 1sby by Molmil
Alcohol dehydrogenase from Drosophila lebanonensis complexed with NAD+ and 2,2,2-trifluoroethanol at 1.1 A resolution
Descriptor: Alcohol dehydrogenase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, TRIFLUOROETHANOL
Authors:Benach, J, Meijers, R, Atrian, S, Gonzalez-Duarte, R, Lamzin, V.S, Ladenstein, R.
Deposit date:2004-02-11
Release date:2005-02-22
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (1.1 Å)
Cite:1.1-A crystal structure of D. lebanonensis ADH complexed with NAD+ and 2,2,2-trifluoroethanol
To be Published
1SNY
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BU of 1sny by Molmil
Carbonyl reductase Sniffer of D. melanogaster
Descriptor: NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, sniffer CG10964-PA
Authors:Sgraja, T, Ulschmid, J, Becker, K, Schneuwly, S, Klebe, G, Reuter, K, Heine, A.
Deposit date:2004-03-12
Release date:2004-09-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Structural Insights into the Neuroprotective-acting Carbonyl Reductase Sniffer of Drosophila melanogaster.
J.Mol.Biol., 342, 2004
1SEP
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BU of 1sep by Molmil
MOUSE SEPIAPTERIN REDUCTASE COMPLEXED WITH NADP AND SEPIAPTERIN
Descriptor: BIOPTERIN, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, SEPIAPTERIN REDUCTASE
Authors:Auerbach, G, Herrmann, A, Guetlich, M, Fischer, M, Jacob, U, Bacher, A, Huber, R.
Deposit date:1997-05-23
Release date:1999-01-13
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:The 1.25 A crystal structure of sepiapterin reductase reveals its binding mode to pterins and brain neurotransmitters.
EMBO J., 16, 1997
1U7T
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Crystal Structure of ABAD/HSD10 with a Bound Inhibitor
Descriptor: 1-AZEPAN-1-YL-2-PHENYL-2-(4-THIOXO-1,4-DIHYDRO-PYRAZOLO[3,4-D]PYRIMIDIN-5-YL)ETHANONE ADDUCT, 3-hydroxyacyl-CoA dehydrogenase type II, NICOTINAMIDE-ADENINE-DINUCLEOTIDE
Authors:Kissinger, C.R, Rejto, P.A, Pelletier, L.A, Showalter, R.E, Villafranca, J.E.
Deposit date:2004-08-04
Release date:2004-10-05
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of human ABAD/HSD10 with a bound inhibitor: implications for design of Alzheimer's disease therapeutics
J.Mol.Biol., 342, 2004

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