2IRW

Human 11-beta-Hydroxysteroid Dehydrogenase (HSD1) with NADP and Adamantane Ether Inhibitor

Summary for 2IRW

• Entry DOI: 10.2210/pdb2irw/pdb
• Related: 2ILT
• Descriptor: Corticosteroid 11-beta-dehydrogenase isozyme 1, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, (1S,3R,4S,5S,7S)-4-{[2-(4-METHOXYPHENOXY)-2-METHYLPROPANOYL]AMINO}ADAMANTANE-1-CARBOXAMIDE (3 entities in total)
• Functional Keywords: hsd1, nadp, inhibitor, oxidoreductase
• Biological source: Homo sapiens (human)
• Cellular location: Endoplasmic reticulum membrane ; Single-pass type II membrane protein : P28845
• Total number of polymer chains: 8
• Total formula weight: 241365.54

Authors

Longenecker, K.L.,Patel, J.R.,Russell, J.,Qin, W. (deposition date: 2006-10-16, release date: 2007-01-23, Last modification date: 2024-02-21)

• Primary citation: Patel, J.R.,Shuai, Q.,Dinges, J.,Winn, M.,Pliushchev, M.,Fung, S.,Monzon, K.,Chiou, W.,Wang, J.,Pan, L.,Wagaw, S.,Engstrom, K.,Kerdesky, F.A.,Longenecker, K.,Judge, R.,Qin, W.,Imade, H.M.,Stolarik, D.,Beno, D.W.,Brune, M.,Chovan, L.E.,Sham, H.L.,Jacobson, P.,Link, J.T.; Discovery of adamantane ethers as inhibitors of 11beta-HSD-1: Synthesis and biological evaluation.; Bioorg.Med.Chem.Lett., 17:750-755, 2007; PubMed: 17110106; DOI: 10.1016/j.bmcl.2006.10.074

Experimental method

X-RAY DIFFRACTION (3.1 Å)