4P38

Human 11beta-Hydroxysteroid Dehydrogenase Type 1 in complex with AZD8329

Summary for 4P38

• Entry DOI: 10.2210/pdb4p38/pdb
• Related: 4HFR
• Descriptor: Corticosteroid 11-beta-dehydrogenase isozyme 1, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 4-[4-(2-adamantylcarbamoyl)-5-tert-butyl-pyrazol-1-yl]benzoic acid, ... (5 entities in total)
• Functional Keywords: alpha beta, rossmann fold, nadp, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
• Biological source: Homo sapiens (Human)
• Cellular location: Endoplasmic reticulum membrane ; Single-pass type II membrane protein : P28845
• Total number of polymer chains: 2
• Total formula weight: 60838.64

Authors

Ogg, D.,Hargreaves, D.,Gerhardt, S. (deposition date: 2014-03-06, release date: 2014-04-30, Last modification date: 2024-02-28)

• Primary citation: Scott, J.S.,deSchoolmeester, J.,Kilgour, E.,Mayers, R.M.,Packer, M.J.,Hargreaves, D.,Gerhardt, S.,Ogg, D.J.,Rees, A.,Selmi, N.,Stocker, A.,Swales, J.G.,Whittamore, P.R.; Novel acidic 11 beta-hydroxysteroid dehydrogenase type 1 (11 beta-HSD1) inhibitor with reduced acyl glucuronide liability: the discovery of 4-[4-(2-adamantylcarbamoyl)-5-tert-butyl-pyrazol-1-yl]benzoic acid (AZD8329).; J.Med.Chem., 55:10136-10147, 2012; PubMed: 23088558; DOI: 10.1021/jm301252n

Experimental method

X-RAY DIFFRACTION (2.8 Å)