Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

4PPI
DownloadVisualize
BU of 4ppi by Molmil
Crystal structure of Bcl-xL hexamer
Descriptor: Bcl-2-like protein 1, GLYCEROL
Authors:Sreekanth, R, Yoon, H.S.
Deposit date:2014-02-27
Release date:2015-03-04
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.851 Å)
Cite:Structural transition in Bcl-xL and its potential association with mitochondrial calcium ion transport
Sci Rep, 5, 2015
5VAY
DownloadVisualize
BU of 5vay by Molmil
Bcl-2 complex with Beclin 1 T108D BH3 domain
Descriptor: Apoptosis regulator Bcl-2 -- Bcl-2-like protein 1 Chimera, Beclin-1
Authors:Lee, E.F, Smith, B.J, Yao, S, Fairlie, W.D.
Deposit date:2017-03-28
Release date:2018-04-04
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.804 Å)
Cite:Bcl-2 complex with Beclin 1 pT108 BH3 domain
To Be Published
5VAX
DownloadVisualize
BU of 5vax by Molmil
Bcl-2 complex with Beclin 1 BH3 domain
Descriptor: Apoptosis regulator Bcl-2 -- Bcl-2-like protein 1 Chimera, Beclin-1
Authors:Lee, E.F, Smith, B.J, Yao, S, Fairlie, W.D.
Deposit date:2017-03-28
Release date:2018-04-04
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2 Å)
Cite:Bcl-2 complex with Beclin 1 pT108 BH3 domain
To Be Published
4K5A
DownloadVisualize
BU of 4k5a by Molmil
Co-crystallization with conformation-specific designed ankyrin repeat proteins explains the conformational flexibility of BCL-W
Descriptor: Bcl-2-like protein 2, Designed Ankyrin Repeat Protein 013_D12
Authors:Schilling, J, Schoeppe, J, Sauer, E, Plueckthun, A.
Deposit date:2013-04-14
Release date:2014-04-16
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Co-Crystallization with Conformation-Specific Designed Ankyrin Repeat Proteins Explains the Conformational Flexibility of BCL-W
J.Mol.Biol., 426, 2014
4K5B
DownloadVisualize
BU of 4k5b by Molmil
Co-crystallization with conformation-specific designed ankyrin repeat proteins explains the conformational flexibility of BCL-W
Descriptor: Apoptosis regulator BCL-W, Bcl-2-like protein 2
Authors:Schilling, J, Schoeppe, J, Sauer, E, Plueckthun, A.
Deposit date:2013-04-14
Release date:2014-04-16
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Co-Crystallization with Conformation-Specific Designed Ankyrin Repeat Proteins Explains the Conformational Flexibility of BCL-W
J.Mol.Biol., 426, 2014
5VX3
DownloadVisualize
BU of 5vx3 by Molmil
Bcl-xL in complex with Bim-h3Pc-RT
Descriptor: 1,2-ETHANEDIOL, Bcl-2-like protein 1, Bcl-2-like protein 11
Authors:Cowan, A.D, Brouwer, J.M, Colman, P.M, Czabotar, P.E.
Deposit date:2017-05-23
Release date:2017-11-15
Last modified:2020-01-08
Method:X-RAY DIFFRACTION (1.945 Å)
Cite:Conversion of Bim-BH3 from Activator to Inhibitor of Bak through Structure-Based Design.
Mol. Cell, 68, 2017
5VAU
DownloadVisualize
BU of 5vau by Molmil
Bcl-2 complex with Beclin 1 BH3 domain
Descriptor: Apoptosis regulator Bcl-2 -- Bcl-2-like protein 1 Chimera, Beclin-1
Authors:Lee, E.F, Smith, B.J, Yao, S, Fairlie, W.D.
Deposit date:2017-03-28
Release date:2018-04-04
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.754 Å)
Cite:Bcl-2 complex with Beclin 1 BH3 domain
To Be Published
4HNJ
DownloadVisualize
BU of 4hnj by Molmil
Crystallographic structure of BCL-xL domain-swapped dimer in complex with PUMA BH3 peptide at 2.9A resolution
Descriptor: Bcl-2-binding component 3, Bcl-2-like protein 1
Authors:Fisher, J.C, Yun, M.K, White, S.W.
Deposit date:2012-10-19
Release date:2013-01-23
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:PUMA binding induces partial unfolding within BCL-xL to disrupt p53 binding and promote apoptosis.
Nat.Chem.Biol., 9, 2013
4IEH
DownloadVisualize
BU of 4ieh by Molmil
Crystal Structure of human Bcl-2 in complex with a small molecule inhibitor targeting Bcl-2 BH3 domain interactions
Descriptor: Apoptosis regulator Bcl-2, Bcl-2-like protein 1 chimera, N-(6-{4-[(4'-chlorobiphenyl-2-yl)methyl]piperazin-1-yl}-1,1-dioxido-1,2-benzothiazol-3-yl)-4-{[(2R)-4-(dimethylamino)-1-(phenylsulfanyl)butan-2-yl]amino}-3-nitrobenzenesulfonamide
Authors:Xie, X, Kulathila, R.
Deposit date:2012-12-13
Release date:2013-07-10
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:The role of the acidity of N-heteroaryl sulfonamides as inhibitors of bcl-2 family protein-protein interactions.
ACS Med Chem Lett, 4, 2013
2YQ7
DownloadVisualize
BU of 2yq7 by Molmil
Structure of Bcl-xL bound to BimLOCK
Descriptor: BCL-2-LIKE PROTEIN 1, BCL-2-LIKE PROTEIN 11, GLYCEROL
Authors:Smith, B.J, Czabotar, P.E.
Deposit date:2012-11-06
Release date:2012-11-28
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.901 Å)
Cite:Stabilizing the Pro-Apoptotic Bimbh3 Helix (Bimsahb) Does not Necessarily Enhance Affinity or Biological Activity.
Acs Chem.Biol., 8, 2013
2YXJ
DownloadVisualize
BU of 2yxj by Molmil
Crystal structure of Bcl-xL in complex with ABT-737
Descriptor: 4-{4-[(4'-CHLOROBIPHENYL-2-YL)METHYL]PIPERAZIN-1-YL}-N-{[4-({(1R)-3-(DIMETHYLAMINO)-1-[(PHENYLTHIO)METHYL]PROPYL}AMINO)-3-NITROPHENYL]SULFONYL}BENZAMIDE, Apoptosis regulator Bcl-X, CHLORIDE ION, ...
Authors:Czabotar, P.E, Lee, E.F, Smith, B.J, Deshayes, K, Zobel, K, Fairlie, W.D, Colman, P.M.
Deposit date:2007-04-26
Release date:2007-05-22
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structure of ABT-737 complexed with Bcl-xL: implications for selectivity of antagonists of the Bcl-2 family
Cell Death Differ., 14, 2007
2YJ1
DownloadVisualize
BU of 2yj1 by Molmil
Puma BH3 foldamer in complex with Bcl-xL
Descriptor: ALPHA-BETA-PUMA BH3 FOLDAMER, BCL-2-LIKE PROTEIN 1
Authors:Lee, E.F, Smith, B.J, Horne, W.S, Mayer, K.N, Evangelista, M, Colman, P.M, Gellman, S.H, Fairlie, W.D.
Deposit date:2011-05-18
Release date:2011-10-12
Last modified:2024-05-15
Method:X-RAY DIFFRACTION (2.24 Å)
Cite:Structural Basis of Bcl-Xl Recognition by a Bh3-Mimetic Alpha-Beta-Peptide Generated Via Sequence-Based Design
Chembiochem, 12, 2011
4QNQ
DownloadVisualize
BU of 4qnq by Molmil
Crystal Structure Analysis of full-length Bcl-XL in complex with the inhibitor ABT-263
Descriptor: 4-(4-{[2-(4-chlorophenyl)-5,5-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-[(4-{[(2R)-4-(morpholin-4-yl)-1-(phenylsulfanyl)butan-2-yl]amino}-3-[(trifluoromethyl)sulfonyl]phenyl)sulfonyl]benzamide, Bcl-2-like protein 1
Authors:Korste, A, Vetter, I.R, Stoll, R.
Deposit date:2014-06-18
Release date:2015-10-28
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal Structure Analysis of full-length Bcl-XL in complex with the inhibitor ABT-263
TO BE PUBLISHED
4QVX
DownloadVisualize
BU of 4qvx by Molmil
Discovery of a Potent and Selective BCL-XL Inhibitor That Demonstrates Thrombocytopenia and Inhibits Tumor Growth in Vivo
Descriptor: 2-[8-(1,3-benzothiazol-2-ylcarbamoyl)-3,4-dihydroisoquinolin-2(1H)-yl]-5-(3-{4-[3-(dimethylamino)prop-1-yn-1-yl]-2-fluorophenoxy}propyl)-1,3-thiazole-4-carboxylic acid, Bcl-2-like protein 1
Authors:Park, C.H.
Deposit date:2014-07-16
Release date:2015-07-22
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Discovery of a Potent and Selective BCL-XL Inhibitor with in Vivo Activity.
ACS MED.CHEM.LETT., 5, 2014
4QVF
DownloadVisualize
BU of 4qvf by Molmil
Crystal structure of Bcl-xL in complex with BIM BH3 domain
Descriptor: Bcl-2-like protein 1, Peptide from Bcl-2-like protein 11
Authors:Sreekanth, R, Yoon, H.S.
Deposit date:2014-07-15
Release date:2015-06-10
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (1.531 Å)
Cite:Bh3 induced conformational changes in Bcl-Xl revealed by crystal structure and comparative analysis.
Proteins, 83, 2015
6O0M
DownloadVisualize
BU of 6o0m by Molmil
crystal structure of BCL-2 F104L mutation with venetoclax
Descriptor: 4-{4-[(4'-chloro-5,5-dimethyl[3,4,5,6-tetrahydro[1,1'-biphenyl]]-2-yl)methyl]piperazin-1-yl}-N-[(3-nitro-4-{[(oxan-4-yl )methyl]amino}phenyl)sulfonyl]-2-[(1H-pyrrolo[2,3-b]pyridin-5-yl)oxy]benzamide, Apoptosis regulator Bcl-2,Bcl-2-like protein 1,Apoptosis regulator Bcl-2, DI(HYDROXYETHYL)ETHER
Authors:Birkinshaw, R.W, Luo, C.S, Colman, P.M, Czabotar, P.E.
Deposit date:2019-02-16
Release date:2019-05-22
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Structures of BCL-2 in complex with venetoclax reveal the molecular basis of resistance mutations.
Nat Commun, 10, 2019
6O0K
DownloadVisualize
BU of 6o0k by Molmil
crystal structure of BCL-2 with venetoclax
Descriptor: 4-{4-[(4'-chloro-5,5-dimethyl[3,4,5,6-tetrahydro[1,1'-biphenyl]]-2-yl)methyl]piperazin-1-yl}-N-[(3-nitro-4-{[(oxan-4-yl )methyl]amino}phenyl)sulfonyl]-2-[(1H-pyrrolo[2,3-b]pyridin-5-yl)oxy]benzamide, Apoptosis regulator Bcl-2, NONAETHYLENE GLYCOL
Authors:Birkinshaw, R.W, Luo, C.S, Colman, P.M, Czabotar, P.E.
Deposit date:2019-02-16
Release date:2019-05-22
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.62 Å)
Cite:Structures of BCL-2 in complex with venetoclax reveal the molecular basis of resistance mutations.
Nat Commun, 10, 2019
4QVE
DownloadVisualize
BU of 4qve by Molmil
Crystal structure of Bcl-xL in complex with BID BH3 domain
Descriptor: Bcl-2-like protein 1, IMIDAZOLE, Peptide from BH3-interacting domain death agonist
Authors:Sreekanth, R, Yoon, H.S.
Deposit date:2014-07-14
Release date:2015-06-10
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Bh3 induced conformational changes in Bcl-Xl revealed by crystal structure and comparative analysis.
Proteins, 83, 2015
2Y6W
DownloadVisualize
BU of 2y6w by Molmil
Structure of a Bcl-w dimer
Descriptor: BCL-2-LIKE PROTEIN 2, DI(HYDROXYETHYL)ETHER, TRIETHYLENE GLYCOL
Authors:Lee, E.F, Evangelista, M, Pettikiriarachchi, A, Dogovski, C, Perugini, M.A, Colman, P.M, Fairlie, W.D.
Deposit date:2011-01-27
Release date:2011-10-26
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal Structure of a Bcl-W Domain-Swapped Dimer: Implications for the Function of Bcl-2 Family Proteins.
Structure, 19, 2011
2YQ6
DownloadVisualize
BU of 2yq6 by Molmil
Structure of Bcl-xL bound to BimSAHB
Descriptor: BCL-2-LIKE PROTEIN 1, BIM BETA 5, GLYCEROL
Authors:Smith, B.J, Czabotar, P.E.
Deposit date:2012-11-06
Release date:2012-11-28
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.799 Å)
Cite:Stabilizing the Pro-Apoptotic Bimbh3 Helix (Bimsahb) Does not Necessarily Enhance Affinity or Biological Activity.
Acs Chem.Biol., 8, 2013
6O0L
DownloadVisualize
BU of 6o0l by Molmil
crystal structure of BCL-2 G101V mutation with venetoclax
Descriptor: 4-{4-[(4'-chloro-5,5-dimethyl[3,4,5,6-tetrahydro[1,1'-biphenyl]]-2-yl)methyl]piperazin-1-yl}-N-[(3-nitro-4-{[(oxan-4-yl )methyl]amino}phenyl)sulfonyl]-2-[(1H-pyrrolo[2,3-b]pyridin-5-yl)oxy]benzamide, Apoptosis regulator Bcl-2,Bcl-2-like protein 1,Apoptosis regulator Bcl-2, CHLORIDE ION, ...
Authors:Birkinshaw, R.W, Luo, C.S, Colman, P.M, Czabotar, P.E.
Deposit date:2019-02-16
Release date:2019-05-22
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structures of BCL-2 in complex with venetoclax reveal the molecular basis of resistance mutations.
Nat Commun, 10, 2019
6O0P
DownloadVisualize
BU of 6o0p by Molmil
crystal structure of BCL-2 G101A mutation with venetoclax
Descriptor: 4-{4-[(4'-chloro-5,5-dimethyl[3,4,5,6-tetrahydro[1,1'-biphenyl]]-2-yl)methyl]piperazin-1-yl}-N-[(3-nitro-4-{[(oxan-4-yl )methyl]amino}phenyl)sulfonyl]-2-[(1H-pyrrolo[2,3-b]pyridin-5-yl)oxy]benzamide, Apoptosis regulator Bcl-2,Bcl-2-like protein 1,Apoptosis regulator Bcl-2, DI(HYDROXYETHYL)ETHER
Authors:Birkinshaw, R.W, Luo, C.S, Colman, P.M, Czabotar, P.E.
Deposit date:2019-02-17
Release date:2019-05-22
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structures of BCL-2 in complex with venetoclax reveal the molecular basis of resistance mutations.
Nat Commun, 10, 2019
6O0O
DownloadVisualize
BU of 6o0o by Molmil
crystal structure of BCL-2 G101V mutation with S55746
Descriptor: Apoptosis regulator Bcl-2,Bcl-2-like protein 1,Apoptosis regulator Bcl-2, ~{N}-(4-hydroxyphenyl)-3-[6-[[(3~{S})-3-(morpholin-4-ylmethyl)-3,4-dihydro-1~{H}-isoquinolin-2-yl]carbonyl]-1,3-benzodioxol-5-yl]-~{N}-phenyl-5,6,7,8-tetrahydroindolizine-1-carboxamide
Authors:Birkinshaw, R.W, Luo, C.S, Colman, P.M, Czabotar, P.E.
Deposit date:2019-02-17
Release date:2019-05-22
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.998 Å)
Cite:Structures of BCL-2 in complex with venetoclax reveal the molecular basis of resistance mutations.
Nat Commun, 10, 2019
1YSN
DownloadVisualize
BU of 1ysn by Molmil
Solution structure of the anti-apoptotic protein Bcl-xL complexed with an acyl-sulfonamide-based ligand
Descriptor: 3-NITRO-N-{4-[2-(2-PHENYLETHYL)-1,3-BENZOTHIAZOL-5-YL]BENZOYL}-4-{[2-(PHENYLSULFANYL)ETHYL]AMINO}BENZENESULFONAMIDE, Apoptosis regulator Bcl-X
Authors:Oltersdorf, T, Elmore, S.W, Shoemaker, A.R, Armstrong, R.C, Augeri, D.J, Belli, B.A, Bruncko, M, Deckwerth, T.L, Dinges, J, Hajduk, P.J, Joseph, M.K, Kitada, S, Korsmeyer, S.J, Kunzer, A.R, Letai, A, Li, C, Mitten, M.J, Nettesheim, D.G, Ng, S, Nimmer, P.M, O'Connor, J.M, Oleksijew, A, Petros, A.M, Reed, J.C, Shen, W, Tahir, S.K, Thompson, C.B, Tomaselli, K.J, Wang, B, Wendt, M.D, Zhang, H, Fesik, S.W, Rosenberg, S.H.
Deposit date:2005-02-08
Release date:2005-06-07
Last modified:2023-11-29
Method:SOLUTION NMR
Cite:An inhibitor of Bcl-2 family proteins induces regression of solid tumours
Nature, 435, 2005
4TUH
DownloadVisualize
BU of 4tuh by Molmil
Bcl-xL in complex with inhibitor (Compound 10)
Descriptor: 1,2-ETHANEDIOL, 2-[8-(1,3-benzothiazol-2-ylcarbamoyl)-3,4-dihydroisoquinolin-2(1H)-yl]-5-{3-[4-(1H-pyrazolo[3,4-d]pyrimidin-1-yl)phenoxy]propyl}-1,3-thiazole-4-carboxylic acid, ACETATE ION, ...
Authors:Czabotar, P.E, Lessense, G, Smith, B.J, Colman, P.M.
Deposit date:2014-06-24
Release date:2014-10-15
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structure-Guided Rescaffolding of Selective Antagonists of BCL-XL.
Acs Med.Chem.Lett., 5, 2014

225158

PDB entries from 2024-09-18

PDB statisticsPDBj update infoContact PDBjnumon