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1A4O
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BU of 1a4o by Molmil
14-3-3 PROTEIN ZETA ISOFORM
Descriptor: 14-3-3 PROTEIN ZETA
Authors:Liu, D, Bienkowska, J, Petosa, C, Collier, R.J, Fu, H, Liddington, R.C.
Deposit date:1998-02-01
Release date:1999-03-02
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal structure of the zeta isoform of the 14-3-3 protein.
Nature, 376, 1995
3E6Y
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Structure of 14-3-3 in complex with the differentiation-inducing agent Cotylenin A
Descriptor: 14-3-3-like protein C, CHLORIDE ION, Cotylenin A, ...
Authors:Ottmann, C, Weyand, M, Wittinghofer, A, Oecking, C.
Deposit date:2008-08-17
Release date:2009-03-10
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:A structural rationale for selective stabilization of anti-tumor interactions of 14-3-3 proteins by cotylenin A
J.Mol.Biol., 386, 2009
3EFZ
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BU of 3efz by Molmil
Crystal Structure of a 14-3-3 protein from cryptosporidium parvum (cgd1_2980)
Descriptor: 1,2-ETHANEDIOL, 14-3-3 protein
Authors:Wernimont, A.K, Dong, A, Qiu, W, Lew, J, Wasney, G.A, Vedadi, M, Kozieradzki, I, Zhao, Y, Ren, H, Alam, Z, Lin, Y.H, Sundstrom, M, Weigelt, J, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Hui, R, Brokx, S, Structural Genomics Consortium (SGC)
Deposit date:2008-09-10
Release date:2008-09-23
Last modified:2012-02-22
Method:X-RAY DIFFRACTION (2.08 Å)
Cite:Characterization of 14-3-3 proteins from Cryptosporidium parvum.
Plos One, 6, 2011
5ULO
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BU of 5ulo by Molmil
Crystal Structure of 14-3-3 zeta in Complex with a Serine 124-phosphorylated TBC1D7 peptide
Descriptor: 1,2-ETHANEDIOL, 14-3-3 protein zeta/delta, L-PROLINAMIDE, ...
Authors:DONG, A, HU, J, MADIGAN, J, WALKER, J.R, Bountra, C, Arrowsmith, C.H, Edwards, A.M, TONG, Y, Structural Genomics Consortium (SGC)
Deposit date:2017-01-25
Release date:2018-01-31
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.14 Å)
Cite:Crystal Structure of 14-3-3 zeta in Complex with a Serine 124-phosphorylated TBC1D7 peptide
to be published
3IQU
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Crystal Structure of human 14-3-3 sigma in Complex with Raf1 peptide (6mer)
Descriptor: 14-3-3 protein sigma, 6-mer from RAF proto-oncogene serine/threonine-protein kinase, CHLORIDE ION, ...
Authors:Ottmann, C, Weyand, M.
Deposit date:2009-08-21
Release date:2010-09-01
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.05 Å)
Cite:Impaired binding of 14-3-3 to C-RAF in Noonan syndrome suggests new approaches in diseases with increased Ras signaling.
Mol.Cell.Biol., 30, 2010
3IQJ
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BU of 3iqj by Molmil
Crystal Structure of human 14-3-3 sigma in Complex with Raf1 peptide (10mer)
Descriptor: 10-mer peptide from RAF proto-oncogene serine/threonine-protein kinase, 14-3-3 protein sigma, CHLORIDE ION, ...
Authors:Ottmann, C, Weyand, M.
Deposit date:2009-08-20
Release date:2010-09-01
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.15 Å)
Cite:Impaired binding of 14-3-3 to C-RAF in Noonan syndrome suggests new approaches in diseases with increased Ras signaling.
Mol.Cell.Biol., 30, 2010
3IQV
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BU of 3iqv by Molmil
Crystal Structure of human 14-3-3 sigma in Complex with Raf1 peptide (6mer) and stabilisator Fusicoccin
Descriptor: 14-3-3 protein sigma, 6-mer peptide from RAF proto-oncogene serine/threonine-protein kinase, CHLORIDE ION, ...
Authors:Ottmann, C, Weyand, M.
Deposit date:2009-08-21
Release date:2010-09-01
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:Impaired binding of 14-3-3 to C-RAF in Noonan syndrome suggests new approaches in diseases with increased Ras signaling.
Mol.Cell.Biol., 30, 2010
1A37
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14-3-3 PROTEIN ZETA BOUND TO PS-RAF259 PEPTIDE
Descriptor: 14-3-3 PROTEIN ZETA, PS-RAF259 PEPTIDE LSQRQRST(SEP)TPNVHM
Authors:Petosa, C, Masters, S.C, Pohl, J, Wang, B, Fu, H, Liddington, R.C.
Deposit date:1998-01-28
Release date:1999-03-02
Last modified:2024-06-05
Method:X-RAY DIFFRACTION (3.6 Å)
Cite:14-3-3zeta binds a phosphorylated Raf peptide and an unphosphorylated peptide via its conserved amphipathic groove.
J.Biol.Chem., 273, 1998
3CU8
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BU of 3cu8 by Molmil
Impaired binding of 14-3-3 to Raf1 is linked to Noonan and LEOPARD syndrome
Descriptor: 14-3-3 protein zeta/delta, MAGNESIUM ION, PROPANOIC ACID, ...
Authors:Schumacher, B, Weyand, M, Kuhlmann, J, Ottmann, C.
Deposit date:2008-04-16
Release date:2009-05-05
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Impaired binding of 14-3-3 to C-RAF in Noonan syndrome suggests new approaches in diseases with increased Ras signaling.
Mol. Cell. Biol., 30, 2010
5WFX
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BU of 5wfx by Molmil
Structural basis for the interaction of 14-3-3beta with Tricarboxylic Acid Cycle intermediate Malate
Descriptor: 14-3-3 protein beta/alpha
Authors:Hou, Z.Q.
Deposit date:2017-07-12
Release date:2018-05-16
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.651 Å)
Cite:Structural basis for the interaction of 14-3-3 beta withTricarboxylic Acid Cycle intermediate Malate
To Be Published
5WFU
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BU of 5wfu by Molmil
Structural basis for the interaction of 14-3-3beta with Tricarboxylic Acid Cycle intermediate Malate
Descriptor: 14-3-3 protein beta/alpha, D-MALATE
Authors:Hou, Z.Q, Liu, X.Y.
Deposit date:2017-07-12
Release date:2018-07-18
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.97 Å)
Cite:Structural basis for the interaction of 14-3-3beta with Tricarboxylic Acid Cycle intermediate Malate
To Be Published
4ZQ0
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BU of 4zq0 by Molmil
crystal structure of Giardia 14-3-3 in complex with the phosphopeptide A8Ap
Descriptor: 14-3-3 protein, A8Ap phosphopeptide, PHOSPHATE ION
Authors:Fiorillo, A, Ilari, A.
Deposit date:2015-05-08
Release date:2016-03-30
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Molecular Dynamics Simulations and Structural Analysis of Giardia duodenalis 14-3-3 Protein-Protein Interactions.
J.Chem.Inf.Model., 55, 2015
4N7Y
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BU of 4n7y by Molmil
Crystal structure of 14-3-3zeta in complex with a 8-carbon-linker cyclic peptide derived from ExoS
Descriptor: 14-3-3 protein zeta/delta, Exoenzyme S
Authors:Bier, D, Glas, A, Hahne, G, Grossmann, T, Ottmann, C.
Deposit date:2013-10-16
Release date:2014-02-19
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.16 Å)
Cite:Constrained peptides with target-adapted cross-links as inhibitors of a pathogenic protein-protein interaction.
Angew.Chem.Int.Ed.Engl., 53, 2014
3LW1
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BU of 3lw1 by Molmil
Binary complex of 14-3-3 sigma and p53 pT387-peptide
Descriptor: 14-3-3 protein sigma, CHLORIDE ION, GLYCEROL, ...
Authors:Schumacher, B, Mondry, J, Thiel, P, Weyand, M, Ottmann, C.
Deposit date:2010-02-23
Release date:2010-03-23
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.28 Å)
Cite:Structure of the p53 C-terminus bound to 14-3-3: Implications for stabilization of the p53 tetramer
Febs Lett., 584, 2010
4O46
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BU of 4o46 by Molmil
14-3-3-gamma in complex with influenza NS1 C-terminal tail phosphorylated at S228
Descriptor: 14-3-3 protein gamma, Nonstructural protein 1, UNKNOWN ATOM OR ION, ...
Authors:Qin, S, Liu, Y, Tempel, W, Arrowsmith, C.H, Bountra, C, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC)
Deposit date:2013-12-18
Release date:2014-04-30
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structural basis for histone mimicry and hijacking of host proteins by influenza virus protein NS1.
Nat Commun, 5, 2014
3M51
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BU of 3m51 by Molmil
Structure of the 14-3-3/PMA2 complex stabilized by Pyrrolidone1
Descriptor: 14-3-3-like protein C, 2-hydroxy-5-[(5S)-3-hydroxy-5-(4-nitrophenyl)-2-oxo-4-(phenylcarbonyl)-2,5-dihydro-1H-pyrrol-1-yl]benzoic acid, N.plumbaginifolia H+-translocating ATPase mRNA
Authors:Ottmann, C, Rose, R, Waldmann, H.
Deposit date:2010-03-12
Release date:2010-05-26
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (3.25 Å)
Cite:Identification and structure of small-molecule stabilizers of 14-3-3 protein-protein interactions
Angew.Chem.Int.Ed.Engl., 49, 2010
3M50
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BU of 3m50 by Molmil
Structure of the 14-3-3/PMA2 complex stabilized by Epibestatin
Descriptor: 14-3-3-like protein C, N-[(2R,3R)-3-amino-2-hydroxy-4-phenylbutanoyl]-L-leucine, N.plumbaginifolia H+-translocating ATPase mRNA
Authors:Ottmann, C, Rose, R, Waldmann, H.
Deposit date:2010-03-12
Release date:2010-05-26
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Identification and structure of small-molecule stabilizers of 14-3-3 protein-protein interactions
Angew.Chem.Int.Ed.Engl., 49, 2010
4Y5I
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BU of 4y5i by Molmil
Crystal structure of C-terminal modified Tau peptide-hybrid 126B with 14-3-3sigma
Descriptor: 14-3-3 protein sigma, CHLORIDE ION, Microtubule-associated protein tau
Authors:Leysen, S, Bartel, M, Milroy, L, Brunsveld, L, Ottmann, C.
Deposit date:2015-02-11
Release date:2016-01-13
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Stabilizer-Guided Inhibition of Protein-Protein Interactions.
Angew.Chem.Int.Ed.Engl., 54, 2015
3MHR
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BU of 3mhr by Molmil
14-3-3 sigma in complex with YAP pS127-peptide
Descriptor: 14-3-3 protein sigma, CALCIUM ION, CHLORIDE ION, ...
Authors:Schumacher, B, Skwarczynska, M, Rose, R, Ottmann, C.
Deposit date:2010-04-08
Release date:2010-09-15
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.15 Å)
Cite:Structure of a 14-3-3[sigma]-YAP phosphopeptide complex at 1.15 A resolution
Acta Crystallogr.,Sect.F, 66, 2010
4ZDR
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BU of 4zdr by Molmil
Crystal structure of 14-3-3[zeta]-LKB1 fusion protein
Descriptor: 14-3-3 protein zeta/delta,GGSGGS linker,Serine/threonine-protein kinase STK11, GLYCEROL, PROPANE, ...
Authors:Ding, S, Shi, Z.B.
Deposit date:2015-04-18
Release date:2015-09-09
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.899 Å)
Cite:Structure of the 14-3-3 zeta-LKB1 fusion protein provides insight into a novel ligand-binding mode of 14-3-3.
Acta Crystallogr.,Sect.F, 71, 2015
2O02
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BU of 2o02 by Molmil
Phosphorylation independent interactions between 14-3-3 and Exoenzyme S: from structure to pathogenesis
Descriptor: 14-3-3 protein zeta/delta, BENZOIC ACID, ExoS (416-430) peptide
Authors:Ottmann, C, Yasmin, L, Weyand, M, Hauser, A.R, Wittinghofer, A, Hallberg, B.
Deposit date:2006-11-27
Release date:2007-11-27
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Phosphorylation-independent interaction between 14-3-3 and exoenzyme S: from structure to pathogenesis
Embo J., 26, 2007
2O8P
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BU of 2o8p by Molmil
Crystal structure of a putative 14-3-3 protein from Cryptosporidium parvum, cgd7_2470
Descriptor: 14-3-3 domain containing protein
Authors:Dong, A, Lew, J, Wasney, G, Lin, L, Hassanali, A, Zhao, Y, Vedadi, M, Kozieradzki, I, Edwards, A.M, Arrowsmith, C.H, Weigelt, J, Sundstrom, M, Walker, J.R, Bochkarev, A, Hui, R, Brokx, S.J, Structural Genomics Consortium (SGC)
Deposit date:2006-12-12
Release date:2007-01-09
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (1.82 Å)
Cite:Characterization of 14-3-3 proteins from Cryptosporidium parvum.
Plos One, 6, 2011
4N7G
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BU of 4n7g by Molmil
Crystal structure of 14-3-3zeta in complex with a peptide derived from ExoS
Descriptor: 14-3-3 protein zeta/delta, Exoenzyme S, HEXAETHYLENE GLYCOL
Authors:Bier, D, Glas, A, Hahne, G, Grossmann, T, Ottmann, C.
Deposit date:2013-10-15
Release date:2014-02-19
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Constrained peptides with target-adapted cross-links as inhibitors of a pathogenic protein-protein interaction.
Angew.Chem.Int.Ed.Engl., 53, 2014
4N84
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BU of 4n84 by Molmil
Crystal structure of 14-3-3zeta in complex with a 12-carbon-linker cyclic peptide derived from ExoS
Descriptor: 14-3-3 protein zeta/delta, Exoenzyme S
Authors:Bier, D, Glas, A, Hahne, G, Grossmann, T, Ottmann, C.
Deposit date:2013-10-17
Release date:2014-02-19
Last modified:2014-03-12
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Constrained peptides with target-adapted cross-links as inhibitors of a pathogenic protein-protein interaction.
Angew.Chem.Int.Ed.Engl., 53, 2014
5BTV
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BU of 5btv by Molmil
Crystal structure of human 14-3-3 sigma in complex with a Tau-protein peptide surrounding pS324
Descriptor: 14-3-3 protein sigma, CALCIUM ION, CHLORIDE ION, ...
Authors:Ottmann, C, Schumacher, B, Bartel, M.
Deposit date:2015-06-03
Release date:2016-07-20
Last modified:2019-03-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Involvement of 14-3-3 in tubulin instability and impaired axon development is mediated by Tau.
Faseb J., 29, 2015

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