3CU8

Impaired binding of 14-3-3 to Raf1 is linked to Noonan and LEOPARD syndrome

Summary for 3CU8

• Entry DOI: 10.2210/pdb3cu8/pdb
• Descriptor: 14-3-3 protein zeta/delta, RAF proto-oncogene serine/threonine-protein kinase, MAGNESIUM ION, ... (5 entities in total)
• Functional Keywords: 14-3-3, zeta, adapter protein, craf1, noonan syndrome, leopard syndrome, phosphoprotein, protein binding, signaling protein
• Biological source: Homo sapiens (Human); More
• Cellular location: Cytoplasm : P63104 P04049
• Total number of polymer chains: 4
• Total formula weight: 57836.96

Authors

Schumacher, B.,Weyand, M.,Kuhlmann, J.,Ottmann, C. (deposition date: 2008-04-16, release date: 2009-05-05, Last modification date: 2017-10-25)

• Primary citation: Molzan, M.,Schumacher, B.,Ottmann, C.,Baljuls, A.,Polzien, L.,Weyand, M.,Thiel, P.,Rose, R.,Rose, M.,Kuhenne, P.,Kaiser, M.,Rapp, U.R.,Kuhlmann, J.,Ottmann, C.; Impaired binding of 14-3-3 to C-RAF in Noonan syndrome suggests new approaches in diseases with increased Ras signaling.; Mol. Cell. Biol., 30:4698-4711, 2010; PubMed: 20679480; DOI: 10.1128/MCB.01636-09

Experimental method

X-RAY DIFFRACTION (2.4 Å)