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3UD7
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Crystal Structure Analysis of FGF1-Disaccharide(NI21) complexes
Descriptor: 2-deoxy-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-1-O-methyl-2-O-sulfo-alpha-L-idopyranuronic acid, Heparin-binding growth factor 1, PHOSPHATE ION
Authors:Hung, S.-C, Shi, Z.
Deposit date:2011-10-27
Release date:2012-11-28
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Divergent synthesis of 48 heparan sulfate-based disaccharides and probing the specific sugar-fibroblast growth factor-1 interaction
J.Am.Chem.Soc., 134, 2012
4OEG
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BU of 4oeg by Molmil
Crystal Structure Analysis of FGF2-Disaccharide (S9I2) complex
Descriptor: 2-deoxy-3,6-di-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-1-O-methyl-2-O-sulfo-alpha-L-idopyranuronic acid, Fibroblast growth factor 2
Authors:Li, Y.C, Hsiao, C.D.
Deposit date:2014-01-13
Release date:2014-07-09
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Interactions that influence the binding of synthetic heparan sulfate based disaccharides to fibroblast growth factor-2.
Acs Chem.Biol., 9, 2014
6KTR
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BU of 6ktr by Molmil
Crystal structure of fibroblast growth factor 19 in complex with Fab
Descriptor: Fibroblast growth factor 19, G1A8-Fab-HC, G1A8-Fab-LC, ...
Authors:Liu, H, Zheng, S, Hou, X, Liu, X, Lv, X, Li, Y, Li, W, Sui, J.
Deposit date:2019-08-28
Release date:2020-07-08
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.59775758 Å)
Cite:Novel Abs targeting the N-terminus of fibroblast growth factor 19 inhibit hepatocellular carcinoma growth without bile-acid-related side-effects.
Cancer Sci., 111, 2020
4OEF
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BU of 4oef by Molmil
Crystal Structure Analysis of FGF2-Disaccharide (S6I2) complex
Descriptor: 2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-1-O-methyl-2-O-sulfo-alpha-L-idopyranuronic acid, Fibroblast growth factor 2
Authors:Li, Y.C, Hsiao, C.D.
Deposit date:2014-01-13
Release date:2014-07-09
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Interactions that influence the binding of synthetic heparan sulfate based disaccharides to fibroblast growth factor-2.
Acs Chem.Biol., 9, 2014
2NTD
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BU of 2ntd by Molmil
Human fibroblast growth factor-1 (140 amino acid form) with Cys117Val/Pro134Cys mutations
Descriptor: Acidic fibroblast growth factor 1, FORMIC ACID
Authors:Dubey, V.K, Blaber, M.
Deposit date:2006-11-07
Release date:2007-07-24
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.52 Å)
Cite:Spackling the Crack: Stabilizing Human Fibroblast Growth Factor-1 by Targeting the N and C terminus beta-Strand Interactions
J.Mol.Biol., 371, 2007
2P39
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BU of 2p39 by Molmil
Crystal structure of human FGF23
Descriptor: 1,3,4,6-tetra-O-sulfo-beta-D-fructofuranose-(2-1)-2,3,4,6-tetra-O-sulfonato-alpha-D-glucopyranose, Fibroblast growth factor 23
Authors:Mohammadi, M.
Deposit date:2007-03-08
Release date:2007-04-10
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Molecular insights into the klotho-dependent, endocrine mode of action of fibroblast growth factor 19 subfamily members.
Mol.Cell.Biol., 27, 2007
2P23
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BU of 2p23 by Molmil
Crystal structure of human FGF19
Descriptor: Fibroblast growth factor 19
Authors:Mohammadi, M.
Deposit date:2007-03-06
Release date:2007-04-10
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Molecular insights into the klotho-dependent, endocrine mode of action of fibroblast growth factor 19 subfamily members.
Mol.Cell.Biol., 27, 2007
3UD8
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BU of 3ud8 by Molmil
Crystal Structure Analysis of FGF1-Disaccharide(NI22) complex
Descriptor: 2-deoxy-3-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-1-O-methyl-2-O-sulfo-alpha-L-idopyranuronic acid, Heparin-binding growth factor 1, PHOSPHATE ION
Authors:Hung, S.-C, Shi, Z.
Deposit date:2011-10-27
Release date:2012-11-28
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.37 Å)
Cite:Divergent synthesis of 48 heparan sulfate-based disaccharides and probing the specific sugar-fibroblast growth factor-1 interaction
J.Am.Chem.Soc., 134, 2012
6M6E
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BU of 6m6e by Molmil
Solution structure of the core domain of Fibroblast growth factor 21 (FGF21)
Descriptor: Fibroblast growth factor 21
Authors:Zhu, L, Zhao, H, Wang, J.
Deposit date:2020-03-14
Release date:2021-01-20
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Dynamic folding modulation generates FGF21 variant against diabetes.
Embo Rep., 22, 2021
6M6F
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BU of 6m6f by Molmil
Solution structure of disulfide bond mutaion of the core domain of Fibroblast growth factor 21 (FGF21)
Descriptor: Fibroblast growth factor 21
Authors:Zhu, L, Zhao, H, Wang, J.
Deposit date:2020-03-14
Release date:2021-01-20
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Dynamic folding modulation generates FGF21 variant against diabetes.
Embo Rep., 22, 2021
4OEE
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BU of 4oee by Molmil
Crystal Structure Analysis of FGF2-Disaccharide (S3I2) complex
Descriptor: 2-deoxy-3-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-1-O-methyl-2-O-sulfo-alpha-L-idopyranuronic acid, Fibroblast growth factor 2
Authors:Li, Y.C, Hsiao, C.D.
Deposit date:2014-01-13
Release date:2014-07-09
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Interactions that influence the binding of synthetic heparan sulfate based disaccharides to fibroblast growth factor-2.
Acs Chem.Biol., 9, 2014
4QAL
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BU of 4qal by Molmil
Crystal structure of C117A mutant of human acidic fibroblast growth factor
Descriptor: CITRATE ANION, Fibroblast growth factor 1
Authors:Blaber, M, Xia, X.
Deposit date:2014-05-05
Release date:2015-03-11
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Mutation choice to eliminate buried free cysteines in protein therapeutics.
J.Pharm.Sci., 104, 2015
3O3Q
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BU of 3o3q by Molmil
Crystal structure of "L44F/M67I/L73V/A103G/deletion 104-106/F108Y/V109L/L111I/C117V/R119G/deletion 120-122" mutant form of Human acidic fibroblast growth factor
Descriptor: GLYCEROL, Heparin-binding growth factor 1
Authors:Lee, J, Blaber, M.
Deposit date:2010-07-25
Release date:2011-02-23
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:A polypeptide "building block"top-down symmetric deconstruction".
J.Mol.Biol., 407, 2011
3HAL
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BU of 3hal by Molmil
Crystal structure of Rabbit acidic fibroblast growth factor
Descriptor: CHLORIDE ION, Fibroblast growth factor 1 isoform 1, SULFATE ION
Authors:Blaber, M, Lee, J.
Deposit date:2009-05-01
Release date:2009-12-22
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:X-ray structure and biophysical properties of rabbit fibroblast growth factor 1.
Acta Crystallogr.,Sect.F, 65, 2009
3HOM
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BU of 3hom by Molmil
Crystal structure of oxidized A66C mutant of Human acidic fibroblast growth factor
Descriptor: Acidic fibroblast growth factor, FORMIC ACID, SULFATE ION
Authors:Blaber, M, Lee, J.
Deposit date:2009-06-02
Release date:2009-10-06
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural basis of conserved cysteine in the fibroblast growth factor family: evidence for a vestigial half-cystine.
J.Mol.Biol., 393, 2009
3K1X
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BU of 3k1x by Molmil
Acidic Fibroblast Growth Factor (FGF-1) complexed with dobesilate
Descriptor: 2,5-dihydroxybenzenesulfonic acid, Heparin-binding growth factor 1
Authors:Romero, A, Fernandez, I.S, Gimenez-Gallego, G.
Deposit date:2009-09-29
Release date:2010-02-02
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.98 Å)
Cite:Gentisic acid, a compound associated with plant defense and a metabolite of aspirin, heads a new class of in vivo fibroblast growth factor inhibitors.
J.Biol.Chem., 285, 2010
3HBW
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BU of 3hbw by Molmil
Crystal Structure of Human Fibroblast Growth Factor Homologous Factor 2A (FHF2A), also referred to as Fibroblast Growth Factor 13A (FGF13A)
Descriptor: Fibroblast growth factor 13
Authors:Mohammadi, M.
Deposit date:2009-05-05
Release date:2009-05-26
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal structure of a fibroblast growth factor homologous factor (FHF) defines a conserved surface on FHFs for binding and modulation of voltage-gated sodium channels.
J.Biol.Chem., 284, 2009
3JUT
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BU of 3jut by Molmil
Acidic Fibroblast Growth Factor (FGF-1) complexed with gentisic acid
Descriptor: 2,5-dihydroxybenzoic acid, Heparin-binding growth factor 1
Authors:Fernandez, I.S, Gimenez-Gallego, G, Romero, A.
Deposit date:2009-09-15
Release date:2010-02-02
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Gentisic acid, a compound associated with plant defense and a metabolite of aspirin, heads a new class of in vivo fibroblast growth factor inhibitors.
J.Biol.Chem., 285, 2010
4Q9G
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BU of 4q9g by Molmil
Crystal structure of K12V/C16S/C117V/P134V mutant of human acidic fibroblast growth factor
Descriptor: FORMIC ACID, Fibroblast growth factor 1, PHOSPHATE ION
Authors:Blaber, M, Xia, X.
Deposit date:2014-05-01
Release date:2015-03-11
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.554 Å)
Cite:Mutation choice to eliminate buried free cysteines in protein therapeutics.
J.Pharm.Sci., 104, 2015
4QBC
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BU of 4qbc by Molmil
Crystal structure of C117T mutant of human acidic fibroblast growth factor in sodium formate buffer
Descriptor: FORMIC ACID, Fibroblast growth factor 1, SULFATE ION
Authors:Blaber, M, Xia, X.
Deposit date:2014-05-07
Release date:2015-03-11
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.519 Å)
Cite:Mutation choice to eliminate buried free cysteines in protein therapeutics.
J.Pharm.Sci., 104, 2015
4QBV
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BU of 4qbv by Molmil
Crystal structure of C117T mutant of human acidic fibroblast growth factor in sodium citrate buffer
Descriptor: CITRATE ANION, Fibroblast growth factor 1
Authors:Blaber, M, Xia, X.
Deposit date:2014-05-08
Release date:2015-03-11
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.497 Å)
Cite:Mutation choice to eliminate buried free cysteines in protein therapeutics.
J.Pharm.Sci., 104, 2015
4QC4
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BU of 4qc4 by Molmil
Crystal structure of C117S mutant of human acidic fibroblast growth factor
Descriptor: CITRATE ANION, Fibroblast growth factor 1, IMIDAZOLE, ...
Authors:Blaber, M, Xia, X.
Deposit date:2014-05-09
Release date:2015-03-11
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.491 Å)
Cite:Mutation choice to eliminate buried free cysteines in protein therapeutics.
J.Pharm.Sci., 104, 2015
4Q9P
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BU of 4q9p by Molmil
Crystal structure of C16T/K12V/C117V/P134V mutant of human acidic fibroblast growth factor
Descriptor: Fibroblast growth factor 1
Authors:Blaber, M, Xia, X.
Deposit date:2014-05-01
Release date:2015-03-11
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Mutation choice to eliminate buried free cysteines in protein therapeutics.
J.Pharm.Sci., 104, 2015
4Q91
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BU of 4q91 by Molmil
Crystal structure of C16A/K12V/C117V/P134V mutant of human acidic fibroblast growth factor
Descriptor: FORMIC ACID, Fibroblast growth factor 1, PHOSPHATE ION
Authors:Xia, X, Blaber, M.
Deposit date:2014-04-28
Release date:2015-03-11
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.799 Å)
Cite:Mutation choice to eliminate buried free cysteines in protein therapeutics.
J.Pharm.Sci., 104, 2015
4QO3
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BU of 4qo3 by Molmil
Crystal structure of C16S/N18S/K12V/C117V/P134V mutant of human acidic fibroblast growth factor
Descriptor: CITRATE ANION, Fibroblast growth factor 1, IMIDAZOLE
Authors:Blaber, M, Xia, X.
Deposit date:2014-06-19
Release date:2015-05-06
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.047 Å)
Cite:Thermodynamics of Cysteine Substitution Suggest Unique Structural Role for Cysteine in Proteins
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