3K1X

Acidic Fibroblast Growth Factor (FGF-1) complexed with dobesilate

Summary for 3K1X

• Entry DOI: 10.2210/pdb3k1x/pdb
• Related: 3JUT
• Descriptor: Heparin-binding growth factor 1, 2,5-dihydroxybenzenesulfonic acid (3 entities in total)
• Functional Keywords: acidic fibroblast growth factor, inhibitors, acetylation, hormone
• Biological source: Homo sapiens (human)
• Cellular location: Secreted: P05230
• Total number of polymer chains: 6
• Total formula weight: 88896.57

Authors

Romero, A.,Fernandez, I.S.,Gimenez-Gallego, G. (deposition date: 2009-09-29, release date: 2010-02-02, Last modification date: 2023-11-01)

• Primary citation: Fernandez, I.S.,Cuevas, P.,Angulo, J.,Lopez-Navajas, P.,Canales-Mayordomo, A.,Gonzalez-Corrochano, R.,Lozano, R.M.,Valverde, S.,Jimenez-Barbero, J.,Romero, A.,Gimenez-Gallego, G.; Gentisic acid, a compound associated with plant defense and a metabolite of aspirin, heads a new class of in vivo fibroblast growth factor inhibitors.; J.Biol.Chem., 285:11714-11729, 2010; PubMed: 20145243; DOI: 10.1074/jbc.M109.064618

Experimental method

X-RAY DIFFRACTION (1.98 Å)