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7F7Q
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BU of 7f7q by Molmil
Enterococcus faecalis GH31 alpha-N-acetylgalactosaminidase D455A in complex with p-nitrophenyl alpha-N-acetylgalactosaminide
Descriptor: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-alpha-D-galactopyranose, GH31 alpha-N-acetylgalactosaminidase, ...
Authors:Miyazaki, T.
Deposit date:2021-06-30
Release date:2021-12-08
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.42 Å)
Cite:Structural and mechanistic insights into the substrate specificity and hydrolysis of GH31 alpha-N-acetylgalactosaminidase.
Biochimie, 195, 2022
7BW7
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BU of 7bw7 by Molmil
Cryo-EM Structure for the Ectodomain of the Full-length Human Insulin Receptor in Complex with 1 Insulin.
Descriptor: Insulin fusion, Insulin receptor
Authors:Yu, D, Zhang, X, Sun, J, Li, X, Wu, Z, Han, X, Fan, C, Ma, Y, Ouyang, Q, Wang, T.
Deposit date:2020-04-13
Release date:2021-04-14
Method:ELECTRON MICROSCOPY (4.1 Å)
Cite:Insulin Binding Induced the Ectodomain Conformational Dynamics in the Full-length Human Insulin Receptor
To Be Published
7BW8
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BU of 7bw8 by Molmil
Cryo-EM Structure for the Insulin Binding Region in the Ectodomain of the Full-length Human Insulin Receptor in Complex with 1 Insulin
Descriptor: Insulin fusion, Insulin receptor
Authors:Yu, D, Zhang, X, Sun, J, Li, X, Wu, Z, Han, X, Fan, C, Ma, Y, Ouyang, Q, Wang, T.
Deposit date:2020-04-14
Release date:2021-04-14
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Insulin Binding Induced the Ectodomain Conformational Dynamics in the Full-length Human Insulin Receptor
To Be Published
7F7R
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BU of 7f7r by Molmil
Enterococcus faecalis GH31 alpha-N-acetylgalactosaminidase D455N in complex with Tn antigen
Descriptor: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-alpha-D-galactopyranose, CALCIUM ION, ...
Authors:Miyazaki, T.
Deposit date:2021-06-30
Release date:2021-12-08
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.63 Å)
Cite:Structural and mechanistic insights into the substrate specificity and hydrolysis of GH31 alpha-N-acetylgalactosaminidase.
Biochimie, 195, 2022
1A22
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BU of 1a22 by Molmil
HUMAN GROWTH HORMONE BOUND TO SINGLE RECEPTOR
Descriptor: GROWTH HORMONE, GROWTH HORMONE RECEPTOR
Authors:De Vos, A.M, Ultsch, M.
Deposit date:1998-01-15
Release date:1998-04-29
Last modified:2023-08-02
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural and functional analysis of the 1:1 growth hormone:receptor complex reveals the molecular basis for receptor affinity.
J.Mol.Biol., 277, 1998
5N47
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BU of 5n47 by Molmil
Structure of Anticalin N7E in complex with the three-domain fragment Fn7B8 of human oncofetal fibronectin
Descriptor: Fibronectin, Neutrophil gelatinase-associated lipocalin
Authors:Schiefner, A, Skerra, A.
Deposit date:2017-02-10
Release date:2018-02-14
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (3 Å)
Cite:Anticalins Reveal High Plasticity in the Mode of Complex Formation with a Common Tumor Antigen.
Structure, 26, 2018
5N48
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BU of 5n48 by Molmil
Structure of Anticalin N9B in complex with extra-domain B of human oncofetal fibronectin
Descriptor: Fibronectin, Neutrophil gelatinase-associated lipocalin
Authors:Schiefner, A, Skerra, A.
Deposit date:2017-02-10
Release date:2018-02-14
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Anticalins Reveal High Plasticity in the Mode of Complex Formation with a Common Tumor Antigen.
Structure, 26, 2018
1AXI
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BU of 1axi by Molmil
STRUCTURAL PLASTICITY AT THE HGH:HGHBP INTERFACE
Descriptor: GROWTH HORMONE, GROWTH HORMONE RECEPTOR, SULFATE ION
Authors:Atwell, S, Ultsch, M, De Vos, A.M, Wells, J.A.
Deposit date:1997-10-15
Release date:1998-01-28
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural plasticity in a remodeled protein-protein interface.
Science, 278, 1997
7QID
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BU of 7qid by Molmil
tentative model of the human insulin receptor ectodomain bound by three insulin
Descriptor: Insulin, Insulin receptor, Isoform Short of Insulin receptor
Authors:Gutman, T, Schaefer, I.B, Poojari, C.S, Vattulainen, I, Strauss, M, Coskun, U.
Deposit date:2021-12-14
Release date:2022-02-02
Method:ELECTRON MICROSCOPY (5 Å)
Cite:Cryo-EM structure of the complete and ligand-saturated insulin receptor ectodomain
J Cell Biol, 219, 2020
7CEG
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BU of 7ceg by Molmil
Crystal structure of the complex between mouse PTP delta and neuroligin-3
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Isoform C of Receptor-type tyrosine-protein phosphatase delta, Neuroligin-3
Authors:Yamagata, A, Yoshida, T, Shiroshima, T, Maeda, A, Fukai, S.
Deposit date:2020-06-23
Release date:2021-02-24
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (3.85 Å)
Cite:Canonical versus non-canonical transsynaptic signaling of neuroligin 3 tunes development of sociality in mice.
Nat Commun, 12, 2021
1BQU
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BU of 1bqu by Molmil
CYTOKYNE-BINDING REGION OF GP130
Descriptor: GLYCEROL, PROTEIN (GP130), SULFATE ION
Authors:Bravo, J, Staunton, D, Heath, J.K, Jones, E.Y.
Deposit date:1998-08-18
Release date:1998-08-26
Last modified:2022-12-21
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of a cytokine-binding region of gp130.
EMBO J., 17, 1998
7BWA
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BU of 7bwa by Molmil
Cryo-EM Structure for the Ectodomain of the Full-length Human Insulin Receptor in Complex with 2 Insulin
Descriptor: Insulin fusion, Insulin receptor
Authors:Yu, D, Zhang, X, Sun, J, Li, X, Wu, Z, Han, X, Fan, C, Ma, Y, Ouyang, Q, Wang, T.
Deposit date:2020-04-14
Release date:2021-04-14
Method:ELECTRON MICROSCOPY (4.9 Å)
Cite:Insulin Binding Induced the Ectodomain Conformational Dynamics in the Full-length Human Insulin Receptor
To Be Published
1P9M
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BU of 1p9m by Molmil
Crystal structure of the hexameric human IL-6/IL-6 alpha receptor/gp130 complex
Descriptor: Interleukin-6, Interleukin-6 receptor alpha chain, Interleukin-6 receptor beta chain
Authors:Boulanger, M.J, Chow, D.C, Brevnova, E.E, Garcia, K.C.
Deposit date:2003-05-12
Release date:2003-07-01
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (3.65 Å)
Cite:Hexameric Structure and Assembly of the Interleukin-6/IL-6 alpha-Receptor/gp130 Complex
Science, 300, 2003
1PVH
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BU of 1pvh by Molmil
Crystal structure of leukemia inhibitory factor in complex with gp130
Descriptor: IODIDE ION, Interleukin-6 receptor beta chain, Leukemia inhibitory factor
Authors:Boulanger, M.J, Bankovich, A.J, Kortemme, T, Baker, D, Garcia, K.C.
Deposit date:2003-06-27
Release date:2003-10-14
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Convergent mechanisms for recognition of divergent cytokines by the shared signaling receptor gp130.
Mol.Cell, 12, 2003
7K7J
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BU of 7k7j by Molmil
EphB6 receptor ectodomain
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Ephrin type-B receptor 6
Authors:Goldgur, Y, Himanen, J.
Deposit date:2020-09-22
Release date:2021-04-07
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (3.004 Å)
Cite:Structure of the EphB6 receptor ectodomain.
Plos One, 16, 2021
6MOK
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BU of 6mok by Molmil
Dimeric DARPin A_distance_R7 complex with EpoR
Descriptor: Dimeric DARPin ANR7 (A_distance_r7), Erythropoietin receptor
Authors:Jude, K.M, Mohan, K, Garcia, K.C, Guo, Y.
Deposit date:2018-10-04
Release date:2019-06-05
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (5.101 Å)
Cite:Topological control of cytokine receptor signaling induces differential effects in hematopoiesis.
Science, 364, 2019
6MOJ
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BU of 6moj by Molmil
Dimeric DARPin A_angle_R5 complex with EpoR
Descriptor: D(-)-TARTARIC ACID, Dimeric DARPin ACR5 (A_angle_R5), Erythropoietin receptor, ...
Authors:Jude, K.M, Mohan, K, Garcia, K.C.
Deposit date:2018-10-04
Release date:2019-06-05
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.431 Å)
Cite:Topological control of cytokine receptor signaling induces differential effects in hematopoiesis.
Science, 364, 2019
6MOE
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BU of 6moe by Molmil
Monomeric DARPin E2 complex with EpoR
Descriptor: 1,2-ETHANEDIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, E2 DARPin, ...
Authors:Jude, K.M, Mohan, K, Garcia, K.C.
Deposit date:2018-10-04
Release date:2019-06-05
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.091 Å)
Cite:Topological control of cytokine receptor signaling induces differential effects in hematopoiesis.
Science, 364, 2019
1I1R
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BU of 1i1r by Molmil
CRYSTAL STRUCTURE OF A CYTOKINE/RECEPTOR COMPLEX
Descriptor: INTERLEUKIN-6 RECEPTOR BETA CHAIN, VIRAL IL-6
Authors:Chow, D, He, X, Snow, A.L, Rose-John, S, Garcia, K.C.
Deposit date:2001-02-02
Release date:2001-03-28
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structure of an extracellular gp130 cytokine receptor signaling complex.
Science, 291, 2001
6MOL
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BU of 6mol by Molmil
Monoextended DARPin M_R12 complex with EpoR
Descriptor: Erythropoietin receptor, GLYCEROL, Monoextended DARPin R12 (M_R12)
Authors:Jude, K.M, Mohan, K, Garcia, K.C, Guo, Y.
Deposit date:2018-10-04
Release date:2019-06-05
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (3.163 Å)
Cite:Topological control of cytokine receptor signaling induces differential effects in hematopoiesis.
Science, 364, 2019
6MOF
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BU of 6mof by Molmil
Monomeric DARPin G2 complex with EpoR
Descriptor: 1,2-ETHANEDIOL, Erythropoietin receptor, G2 DARPin
Authors:Jude, K.M, Mohan, K, Garcia, K.C.
Deposit date:2018-10-04
Release date:2019-06-05
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.894 Å)
Cite:Topological control of cytokine receptor signaling induces differential effects in hematopoiesis.
Science, 364, 2019
6NAJ
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BU of 6naj by Molmil
Integrin AlphaVBeta3 ectodomain bound to Hr10 variant of the 10th domain of Fibronectin.
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Fibronectin, ...
Authors:van Agthoven, J, Arnaout, M.A.
Deposit date:2018-12-05
Release date:2019-12-11
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Structure-guided design of pure orthosteric inhibitors of alpha IIb beta 3 that prevent thrombosis but preserve hemostasis.
Nat Commun, 11, 2020
3L5H
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BU of 3l5h by Molmil
Crystal structure of the full ectodomain of human gp130: New insights into the molecular assembly of receptor complexes
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Interleukin-6 receptor subunit beta, SULFATE ION, ...
Authors:Xu, Y, Garrett, T.P.J, Zhang, J.G.
Deposit date:2009-12-21
Release date:2010-05-19
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (3.6 Å)
Cite:Crystal structure of the entire ectodomain of gp130: insights into the molecular assembly of the tall cytokine receptor complexes.
J.Biol.Chem., 285, 2010
6HN5
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BU of 6hn5 by Molmil
Leucine-zippered human insulin receptor ectodomain with single bound insulin - "upper" membrane-distal part
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Insulin, ...
Authors:Weis, F, Menting, J.G, Margetts, M.B, Chan, S.J, Xu, Y, Tennagels, N, Wohlfart, P, Langer, T, Mueller, C.W, Dreyer, M.K, Lawrence, M.C.
Deposit date:2018-09-14
Release date:2018-11-21
Last modified:2022-03-30
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:The signalling conformation of the insulin receptor ectodomain.
Nat Commun, 9, 2018
1KF9
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BU of 1kf9 by Molmil
PHAGE DISPLAY DERIVED VARIANT OF HUMAN GROWTH HORMONE COMPLEXED WITH TWO COPIES OF THE EXTRACELLULAR DOMAIN OF ITS RECEPTOR
Descriptor: EXTRACELLULAR DOMAIN HUMAN GROWTH HORMONE RECEPTOR (1-238), PHAGE DISPLAY DERIVED VARIANT HUMAN GROWTH HORMONE
Authors:Schiffer, C.A, Ultsch, M, Walsh, S, Somers, W, De Vos, A.M, Kossiakoff, A.A.
Deposit date:2001-11-19
Release date:2002-11-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structure of a Phage Display Derived Variant of Human Growth Hormone Complexed to Two Copies of the Extracellular Domain of its Receptor: Evidence for Strong Structural Coupling between Receptor Binding Sites
J.Mol.Biol., 316, 2002

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