3L1W
| The crystal structure of a functionally unknown conserved protein from Enterococcus faecalis V583 | Descriptor: | 1,2-ETHANEDIOL, FORMIC ACID, SULFATE ION, ... | Authors: | Tan, K, Rakowski, E, Jedrzejczak, R, Joachimiak, A, Midwest Center for Structural Genomics (MCSG) | Deposit date: | 2009-12-14 | Release date: | 2010-01-12 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | The crystal structure of a functionally unknown conserved protein from Enterococcus faecalis V583 To be Published
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8KA4
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3U8U
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6WCD
| Crystal Structure of Xenopus laevis APE2 Catalytic Domain | Descriptor: | 1,2-ETHANEDIOL, 1,4-BUTANEDIOL, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ... | Authors: | Wojtaszek, J.L, Wallace, B.D, Williams, R.S. | Deposit date: | 2020-03-30 | Release date: | 2020-05-06 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.54 Å) | Cite: | Endogenous DNA 3' Blocks Are Vulnerabilities for BRCA1 and BRCA2 Deficiency and Are Reversed by the APE2 Nuclease. Mol.Cell, 78, 2020
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3TEB
| endonuclease/exonuclease/phosphatase family protein from Leptotrichia buccalis C-1013-b | Descriptor: | Endonuclease/exonuclease/phosphatase, MAGNESIUM ION | Authors: | Chang, C, Bigelow, L, Muniez, I, Bearden, J, Joachimiak, A, Midwest Center for Structural Genomics (MCSG) | Deposit date: | 2011-08-12 | Release date: | 2011-08-31 | Method: | X-RAY DIFFRACTION (2.99 Å) | Cite: | Crystal structure of endonuclease/exonuclease/phosphatase family protein from Leptotrichia buccalis C-1013-b To be Published
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5DFH
| Human APE1 mismatch product complex | Descriptor: | 1,2-ETHANEDIOL, DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*T)-3'), DNA (5'-D(*GP*GP*AP*TP*CP*CP*GP*TP*CP*GP*GP*GP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3'), ... | Authors: | Freudenthal, B.D, Wilson, S.H. | Deposit date: | 2015-08-26 | Release date: | 2015-10-14 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.949 Å) | Cite: | Capturing snapshots of APE1 processing DNA damage. Nat.Struct.Mol.Biol., 22, 2015
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7TR7
| APE1 product complex with abasic ssDNA | Descriptor: | DNA (5'-D(P*(3DR)P*CP*GP*AP*TP*GP*C)-3'), DNA-(apurinic or apyrimidinic site) lyase, MAGNESIUM ION | Authors: | Freudenthal, B.D, Hoitsma, N.M. | Deposit date: | 2022-01-28 | Release date: | 2023-04-12 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Mechanistic insight into AP-endonuclease 1 cleavage of abasic sites at stalled replication fork mimics. Nucleic Acids Res., 51, 2023
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1I9Y
| CRYSTAL STRUCTURE OF INOSITOL POLYPHOSPHATE 5-PHOSPHATASE DOMAIN (IPP5C) OF SPSYNAPTOJANIN | Descriptor: | PHOSPHATIDYLINOSITOL PHOSPHATE PHOSPHATASE | Authors: | Tsujishita, Y, Guo, S, Stolz, L, York, J.D, Hurley, J.H. | Deposit date: | 2001-03-21 | Release date: | 2001-05-16 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Specificity determinants in phosphoinositide dephosphorylation: crystal structure of an archetypal inositol polyphosphate 5-phosphatase. Cell(Cambridge,Mass.), 105, 2001
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5DFJ
| Human APE1 E96Q/D210N mismatch substrate complex | Descriptor: | 1,2-ETHANEDIOL, CHLORIDE ION, DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*TP*(3DR)P*CP*GP*AP*CP*GP*GP*AP*TP*CP*C)-3'), ... | Authors: | Freudenthal, B.D, Wilson, S.H. | Deposit date: | 2015-08-26 | Release date: | 2015-10-14 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Capturing snapshots of APE1 processing DNA damage. Nat.Struct.Mol.Biol., 22, 2015
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4LND
| Crystal structure of human apurinic/apyrimidinic endonuclease 1 with essential Mg2+ cofactor | Descriptor: | DNA-(apurinic or apyrimidinic site) lyase, MAGNESIUM ION | Authors: | Manvilla, B.A, Pozharski, E, Toth, E.A, Drohat, A.C. | Deposit date: | 2013-07-11 | Release date: | 2013-11-27 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.92 Å) | Cite: | Structure of human apurinic/apyrimidinic endonuclease 1 with the essential Mg(2+) cofactor. Acta Crystallogr.,Sect.D, 69, 2013
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2O3C
| Crystal structure of zebrafish Ape | Descriptor: | APEX nuclease 1, LEAD (II) ION | Authors: | Georgiadis, M.M, Gaur, R.K, Delaplane, S, Svenson, J. | Deposit date: | 2006-12-01 | Release date: | 2007-12-11 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Evolution of the redox function in mammalian apurinic/apyrimidinic endonuclease Mutat.Res., 643, 2008
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2O3H
| Crystal structure of the human C65A Ape | Descriptor: | ACETATE ION, DNA-(apurinic or apyrimidinic site) lyase, SAMARIUM (III) ION | Authors: | Georgiadis, M.M, Gaur, R.K, Delaplane, S, Svenson, J. | Deposit date: | 2006-12-01 | Release date: | 2007-12-11 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Evolution of the redox function in mammalian apurinic/apyrimidinic endonuclease Mutat.Res., 643, 2008
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1I9Z
| CRYSTAL STRUCTURE OF INOSITOL POLYPHOSPHATE 5-PHOSPHATASE DOMAIN (IPP5C) OF SPSYNAPTOJANIN IN COMPLEX WITH INOSITOL (1,4)-BISPHOSPHATE AND CALCIUM ION | Descriptor: | CALCIUM ION, D-MYO-INOSITOL-1,4-BISPHOSPHATE, PHOSPHATIDYLINOSITOL PHOSPHATE PHOSPHATASE | Authors: | Tsujishita, Y, Guo, S, Stolz, L, York, J.D, Hurley, J.H. | Deposit date: | 2001-03-21 | Release date: | 2001-05-16 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Specificity determinants in phosphoinositide dephosphorylation: crystal structure of an archetypal inositol polyphosphate 5-phosphatase. Cell(Cambridge,Mass.), 105, 2001
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1AKO
| EXONUCLEASE III FROM ESCHERICHIA COLI | Descriptor: | EXONUCLEASE III | Authors: | Mol, C.D, Kuo, C.-F, Thayer, M.M, Cunningham, R.P, Tainer, J.A. | Deposit date: | 1997-05-26 | Release date: | 1997-08-20 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Structure and function of the multifunctional DNA-repair enzyme exonuclease III. Nature, 374, 1995
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4F1R
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4F1H
| Crystal structure of TDP2 from Danio rerio complexed with a single strand DNA | Descriptor: | DNA (5'-D(P*TP*GP*CP*AP*G)-3'), GLYCEROL, MAGNESIUM ION, ... | Authors: | Shi, K, Kurahashi, K, Aihara, H. | Deposit date: | 2012-05-06 | Release date: | 2012-10-31 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.662 Å) | Cite: | Structural basis for recognition of 5'-phosphotyrosine adducts by Tdp2. Nat.Struct.Mol.Biol., 19, 2012
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3W2X
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1VYB
| Endonuclease domain of human LINE1 ORF2p | Descriptor: | GLYCEROL, ORF2 CONTAINS A REVERSE TRANSCRIPTASE DOMAIN, SULFATE ION, ... | Authors: | Weichenrieder, O, Repanas, K, Perrakis, A. | Deposit date: | 2004-04-25 | Release date: | 2004-06-04 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Crystal structure of the targeting endonuclease of the human LINE-1 retrotransposon. Structure, 12, 2004
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6FK5
| Structure of 3' phosphatase NExo (D146N) from Neisseria bound to DNA substrate in presence of magnesium ion | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, DNA (5'-D(P*CP*TP*AP*GP*CP*GP*AP*AP*GP*CP*TP*AP*GP*A)-3'), MAGNESIUM ION, ... | Authors: | Silhan, J, Zhao, Q, Boura, E, Thomson, H, Foster, A, Tang, C.M, Freemont, P.S, Baldwin, G.S. | Deposit date: | 2018-01-23 | Release date: | 2018-10-31 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.02 Å) | Cite: | Structural basis for recognition and repair of the 3'-phosphate by NExo, a base excision DNA repair nuclease from Neisseria meningitidis. Nucleic Acids Res., 46, 2018
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6FKE
| Structure of 3' phosphatase NExo (D146N) from Neisseria bound to product DNA hairpin | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, DNA (5'-D(*GP*TP*AP*GP*CP*GP*AP*AP*GP*CP*TP*A)-3'), Exodeoxyribonuclease III, ... | Authors: | Silhan, J, Zhao, Q, Boura, E, Thomson, H, Foster, A, Tang, C.M, Freemont, P.S, Baldwin, G.S. | Deposit date: | 2018-01-23 | Release date: | 2018-10-31 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.151 Å) | Cite: | Structural basis for recognition and repair of the 3'-phosphate by NExo, a base excision DNA repair nuclease from Neisseria meningitidis. Nucleic Acids Res., 46, 2018
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6FK4
| Structure of 3' phosphatase NExo (WT) from Neisseria bound to DNA substrate | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, DNA (5'-D(P*GP*CP*TP*AP*GP*CP*GP*AP*AP*GP*CP*TP*AP*GP*A)-3'), Exodeoxyribonuclease III | Authors: | Silhan, J, Zhao, Q, Boura, E, Thomson, H, Foster, A, Tang, C.M, Freemont, P.S, Baldwin, G.S. | Deposit date: | 2018-01-23 | Release date: | 2018-10-31 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.297 Å) | Cite: | Structural basis for recognition and repair of the 3'-phosphate by NExo, a base excision DNA repair nuclease from Neisseria meningitidis. Nucleic Acids Res., 46, 2018
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1BIX
| THE CRYSTAL STRUCTURE OF THE HUMAN DNA REPAIR ENDONUCLEASE HAP1 SUGGESTS THE RECOGNITION OF EXTRA-HELICAL DEOXYRIBOSE AT DNA ABASIC SITES | Descriptor: | AP ENDONUCLEASE 1, PLATINUM (II) ION, SAMARIUM (III) ION | Authors: | Gorman, M.A, Morera, S, Rothwell, D.G, De La Fortelle, E, Mol, C.D, Tainer, J.A, Hickson, I.D, Freemont, P.S. | Deposit date: | 1998-06-19 | Release date: | 1999-06-22 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | The crystal structure of the human DNA repair endonuclease HAP1 suggests the recognition of extra-helical deoxyribose at DNA abasic sites. EMBO J., 16, 1997
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5UVG
| Crystal structure of the human neutral sphingomyelinase 2 (nSMase2) catalytic domain with insertion deleted and calcium bound | Descriptor: | CALCIUM ION, Sphingomyelin phosphodiesterase 3,Sphingomyelin phosphodiesterase 3 | Authors: | Airola, M.V, Guja, K.E, Garcia-Diaz, M, Hannun, Y.A. | Deposit date: | 2017-02-20 | Release date: | 2017-06-28 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (1.849 Å) | Cite: | Structure of human nSMase2 reveals an interdomain allosteric activation mechanism for ceramide generation. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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3W2Y
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1ZWX
| Crystal Structure of SmcL | Descriptor: | GLYCEROL, PHOSPHATE ION, sphingomyelinase-c | Authors: | Openshaw, A.E.A, Race, P.R, Monzo, H.J, Vasquez-Boland, J.A, Banfield, M.J. | Deposit date: | 2005-06-06 | Release date: | 2005-08-16 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Crystal structure of SmcL, a bacterial neutral sphingomyelinase C from Listeria. J.Biol.Chem., 280, 2005
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