7TR7

APE1 product complex with abasic ssDNA

Summary for 7TR7

• Entry DOI: 10.2210/pdb7tr7/pdb
• Descriptor: DNA-(apurinic or apyrimidinic site) lyase, DNA (5'-D(P*(3DR)P*CP*GP*AP*TP*GP*C)-3'), MAGNESIUM ION, ... (4 entities in total)
• Functional Keywords: dna repair, abasic ssdna, ap-endonuclease, lyase, lyase-dna complex, lyase/dna
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 4
• Total formula weight: 66340.19

Authors

Freudenthal, B.D.,Hoitsma, N.M. (deposition date: 2022-01-28, release date: 2023-04-12, Last modification date: 2023-10-25)

• Primary citation: Hoitsma, N.M.,Norris, J.,Khoang, T.H.,Kaushik, V.,Chadda, R.,Antony, E.,Hedglin, M.,Freudenthal, B.D.; Mechanistic insight into AP-endonuclease 1 cleavage of abasic sites at stalled replication fork mimics.; Nucleic Acids Res., 51:6738-6753, 2023; PubMed: 37264933; DOI: 10.1093/nar/gkad481

Experimental method

X-RAY DIFFRACTION (2 Å)