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3ZRS
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BU of 3zrs by Molmil
X-ray crystal structure of a KirBac potassium channel highlights a mechanism of channel opening at the bundle-crossing gate.
Descriptor: ATP-SENSITIVE INWARD RECTIFIER POTASSIUM CHANNEL 10, CHLORIDE ION, POTASSIUM ION
Authors:Bavro, V.N, De Zorzi, R, Schmidt, M.R, Muniz, J.R.C, Zubcevic, L, Sansom, M.S.P, Venien-Bryan, C, Tucker, S.J.
Deposit date:2011-06-17
Release date:2012-01-11
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (3.05 Å)
Cite:Structure of a Kirbac Potassium Channel with an Open Bundle Crossing Indicates a Mechanism of Channel Gating
Nat.Struct.Mol.Biol., 19, 2012
4LP8
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BU of 4lp8 by Molmil
A Novel Open-State Crystal Structure of the Prokaryotic Inward Rectifier KirBac3.1
Descriptor: CHLORIDE ION, DI(HYDROXYETHYL)ETHER, Inward rectifier potassium channel Kirbac3.1, ...
Authors:Zubcevic, L, Bavro, V.N, Muniz, J.R.C, Schmidt, M.R, Wang, S, De Zorzi, R, Venien-Bryan, C, Sansom, M.S.P, Nichols, C.G, Tucker, S.J.
Deposit date:2013-07-15
Release date:2013-11-20
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.46 Å)
Cite:Control of KirBac3.1 Potassium Channel Gating at the Interface between Cytoplasmic Domains.
J.Biol.Chem., 289, 2014
7ADI
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BU of 7adi by Molmil
KirBac3.1 W46R: role of a highly conserved tryptophan at the membrane-water interface of Kir channel
Descriptor: Inward rectifier potassium channel Kirbac3.1, MAGNESIUM ION, POTASSIUM ION
Authors:Venien-Bryan, C, Fagnen, C, De Zorzi, R, Bannwarth, L, Oubella, I, Haouz, A.
Deposit date:2020-09-15
Release date:2022-01-12
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Integrative Study of the Structural and Dynamical Properties of a KirBac3.1 Mutant: Functional Implication of a Highly Conserved Tryptophan in the Transmembrane Domain.
Int J Mol Sci, 23, 2021
5KUK
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BU of 5kuk by Molmil
Crystal Structure of Inward Rectifier Kir2.2 K62W Mutant
Descriptor: ATP-sensitive inward rectifier potassium channel 12, DECYL-BETA-D-MALTOPYRANOSIDE, POTASSIUM ION
Authors:Lee, S.-J, Ren, F, Heyman, S, Yuan, P, Nichols, C.G.
Deposit date:2016-07-13
Release date:2016-08-10
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural basis of control of inward rectifier Kir2 channel gating by bulk anionic phospholipids.
J.Gen.Physiol., 148, 2016
5KUM
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BU of 5kum by Molmil
Crystal Structure of Inward Rectifier Kir2.2 K62W Mutant In Complex with PIP2
Descriptor: ATP-sensitive inward rectifier potassium channel 12, DECYL-BETA-D-MALTOPYRANOSIDE, POTASSIUM ION, ...
Authors:Lee, S.-J, Ren, F, Heyman, S, Yuan, P, Nichols, C.G.
Deposit date:2016-07-13
Release date:2016-08-10
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural basis of control of inward rectifier Kir2 channel gating by bulk anionic phospholipids.
J.Gen.Physiol., 148, 2016
8I5M
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BU of 8i5m by Molmil
Rat Kir4.1 in complex with PIP2
Descriptor: ATP-sensitive inward rectifier potassium channel 10, [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate
Authors:Zhao, C, Guo, J.
Deposit date:2023-01-26
Release date:2024-02-28
Last modified:2024-09-11
Method:ELECTRON MICROSCOPY (2.85 Å)
Cite:Pharmacological inhibition of Kir4.1 evokes rapid-onset antidepressant responses.
Nat.Chem.Biol., 20, 2024
8I5N
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BU of 8i5n by Molmil
Rat Kir4.1 in complex with PIP2 and Lys05
Descriptor: ATP-sensitive inward rectifier potassium channel 10, [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate
Authors:Zhao, C, Guo, J.
Deposit date:2023-01-26
Release date:2024-02-28
Last modified:2024-09-11
Method:ELECTRON MICROSCOPY (2.85 Å)
Cite:Pharmacological inhibition of Kir4.1 evokes rapid-onset antidepressant responses.
Nat.Chem.Biol., 20, 2024
1XL6
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BU of 1xl6 by Molmil
Intermediate gating structure 2 of the inwardly rectifying K+ channel KirBac3.1
Descriptor: Inward rectifier potassium channel, MAGNESIUM ION, POTASSIUM ION, ...
Authors:Gulbis, J.M, Kuo, A, Smith, B, Doyle, D.A, Edwards, A, Arrowsmith, C, Sundstrom, M.
Deposit date:2004-09-30
Release date:2004-12-07
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Two intermediate gating state crystal structures of the KirBac3.1 K+ channel
To be Published
1XL4
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BU of 1xl4 by Molmil
Intermediate gating structure 1 of the inwardly rectifying K+ channel KirBac3.1
Descriptor: Inward rectifier potassium channel, MAGNESIUM ION, POTASSIUM ION
Authors:Gulbis, J.M, Kuo, A, Smith, B, Doyle, D.A, Edwards, A, Arrowsmith, C, Sundstrom, M.
Deposit date:2004-09-30
Release date:2004-12-07
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Two intermediate gating state crystal structures of the KirBac3.1 K+ channel
To be Published
3K6N
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BU of 3k6n by Molmil
Crystal structure of the S225E mutant Kir3.1 cytoplasmic pore domain
Descriptor: G protein-activated inward rectifier potassium channel 1, SODIUM ION
Authors:Xu, Y, Shin, H.G, Szep, S, Lu, Z.
Deposit date:2009-10-09
Release date:2009-11-17
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2 Å)
Cite:Physical determinants of strong voltage sensitivity of K(+) channel block.
Nat.Struct.Mol.Biol., 16, 2009
3JYC
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BU of 3jyc by Molmil
Crystal structure of the eukaryotic strong inward-rectifier K+ channel Kir2.2 at 3.1 Angstrom resolution
Descriptor: Inward-rectifier K+ channel Kir2.2, POTASSIUM ION
Authors:Tao, X.
Deposit date:2009-09-21
Release date:2010-01-12
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (3.11 Å)
Cite:Crystal structure of the eukaryotic strong inward-rectifier K+ channel Kir2.2 at 3.1 A resolution.
Science, 326, 2009
6O9T
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BU of 6o9t by Molmil
KirBac3.1 mutant at a resolution of 4.1 Angstroms
Descriptor: 2,3,5,6-tetramethyl-1H,7H-pyrazolo[1,2-a]pyrazole-1,7-dione, Inward rectifier potassium channel Kirbac3.1, POTASSIUM ION
Authors:Gulbis, J.M, Black, K.A, Miller, D.M.
Deposit date:2019-03-15
Release date:2020-05-27
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (4.01 Å)
Cite:A constricted opening in Kir channels does not impede potassium conduction.
Nat Commun, 11, 2020
6O9V
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BU of 6o9v by Molmil
KirBac3.1 mutant at a resolution of 3.1 Angstroms
Descriptor: 1,1-Methanediyl Bismethanethiosulfonate, DECYLAMINE-N,N-DIMETHYL-N-OXIDE, Inward rectifier potassium channel Kirbac3.1, ...
Authors:Gulbis, J.M, Black, K.A, Miller, D.M.
Deposit date:2019-03-15
Release date:2020-05-27
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (3.094 Å)
Cite:A constricted opening in Kir channels does not impede potassium conduction.
Nat Commun, 11, 2020
6O9U
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BU of 6o9u by Molmil
KirBac3.1 at a resolution of 2 Angstroms
Descriptor: 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 3,3',3''-phosphoryltripropanoic acid, BARIUM ION, ...
Authors:Gulbis, J.M, Clarke, O.B.
Deposit date:2019-03-15
Release date:2020-05-27
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2 Å)
Cite:A constricted opening in Kir channels does not impede potassium conduction.
Nat Commun, 11, 2020
7ZDZ
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BU of 7zdz by Molmil
Cryo-EM structure of the human inward-rectifier potassium 2.1 channel (Kir2.1)
Descriptor: Inward rectifier potassium channel 2, POTASSIUM ION, STRONTIUM ION
Authors:Fernandes, C.A.H, Venien-Bryan, C, Fagnen, C, Zuniga, D.
Deposit date:2022-03-30
Release date:2022-09-28
Last modified:2022-10-05
Method:ELECTRON MICROSCOPY (4.3 Å)
Cite:Cryo-electron microscopy unveils unique structural features of the human Kir2.1 channel.
Sci Adv, 8, 2022
6XIS
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BU of 6xis by Molmil
Cryo-EM structure of the G protein-gated inward rectifier K+ channel GIRK2 (Kir3.2) in apo form
Descriptor: G protein-activated inward rectifier potassium channel 2
Authors:Niu, Y, Tao, X, MacKinnon, R.
Deposit date:2020-06-21
Release date:2020-10-07
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Cryo-EM analysis of PIP 2 regulation in mammalian GIRK channels.
Elife, 9, 2020
6XIT
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BU of 6xit by Molmil
Cryo-EM structure of the G protein-gated inward rectifier K+ channel GIRK2 (Kir3.2) in complex with PIP2
Descriptor: G protein-activated inward rectifier potassium channel 2, POTASSIUM ION, [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate
Authors:Niu, Y, Tao, X, MacKinnon, R.
Deposit date:2020-06-21
Release date:2020-10-07
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Cryo-EM analysis of PIP 2 regulation in mammalian GIRK channels.
Elife, 9, 2020
6XEU
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BU of 6xeu by Molmil
CryoEM structure of GIRK2PIP2* - G protein-gated inwardly rectifying potassium channel GIRK2 with PIP2
Descriptor: G protein-activated inward rectifier potassium channel 2, POTASSIUM ION, SODIUM ION, ...
Authors:Mathiharan, Y.K, Glaaser, I.W, Skiniotis, G, Slesinger, P.A.
Deposit date:2020-06-13
Release date:2021-09-01
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Structural insights into GIRK2 channel modulation by cholesterol and PIP2
Cell Rep, 36, 2021
6XEV
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BU of 6xev by Molmil
CryoEM structure of GIRK2-PIP2/CHS - G protein-gated inwardly rectifying potassium channel GIRK2 with modulators cholesteryl hemisuccinate and PIP2
Descriptor: CHOLESTEROL HEMISUCCINATE, G protein-activated inward rectifier potassium channel 2, POTASSIUM ION, ...
Authors:Mathiharan, Y.K, Glaaser, I.W, Skiniotis, G, Slesinger, P.A.
Deposit date:2020-06-14
Release date:2021-09-01
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Structural insights into GIRK2 channel modulation by cholesterol and PIP2
Cell Rep, 36, 2021
6M84
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BU of 6m84 by Molmil
Crystal structure of cKir2.2 force open mutant in complex with PI(4,5)P2
Descriptor: ATP-sensitive inward rectifier potassium channel 12, DODECYL-BETA-D-MALTOSIDE, POTASSIUM ION, ...
Authors:Lee, S.-J, Ren, F, Yuan, P, Nichols, C.G.
Deposit date:2018-08-21
Release date:2019-09-04
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.81 Å)
Cite:Atomistic basis of opening and conduction in mammalian inward rectifier potassium (Kir2.2) channels.
J.Gen.Physiol., 152, 2020
6M85
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BU of 6m85 by Molmil
Crystal Structure of Inward Rectifier Kir2.2 in a different salt condition
Descriptor: ATP-sensitive inward rectifier potassium channel 12, POTASSIUM ION
Authors:Lee, S.-J, Nichols, C.G.
Deposit date:2018-08-21
Release date:2019-09-04
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.71 Å)
Cite:Atomistic basis of opening and conduction in mammalian inward rectifier potassium (Kir2.2) channels.
J.Gen.Physiol., 152, 2020
6M86
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BU of 6m86 by Molmil
Crystal Structure of Inward Rectifier Kir2.2 Force Open Mutant
Descriptor: ATP-sensitive inward rectifier potassium channel 12, POTASSIUM ION
Authors:Lee, S.-J, Ren, F, Yuan, P, Nichols, C.G.
Deposit date:2018-08-21
Release date:2019-09-04
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (3.6 Å)
Cite:Potassium conduction through an eukarytoic inwardly rectifying potassium channel
To be published
7S5T
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BU of 7s5t by Molmil
Human KATP channel in open conformation, focused on Kir (C166S G334D double mutant) and SUR TMD0
Descriptor: ATP-sensitive inward rectifier potassium channel 11, POTASSIUM ION
Authors:Zhao, C, MacKinnon, R.
Deposit date:2021-09-12
Release date:2021-12-01
Last modified:2021-12-08
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Molecular structure of an open human K ATP channel.
Proc.Natl.Acad.Sci.USA, 118, 2021
7N9L
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BU of 7n9l by Molmil
KirBac3.1 C71S C262S
Descriptor: 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, Inward rectifier potassium channel Kirbac3.1, POTASSIUM ION, ...
Authors:Gulbis, J.M, Black, K.A.
Deposit date:2021-06-18
Release date:2021-12-29
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Ion currents through Kir potassium channels are gated by anionic lipids.
Nat Commun, 13, 2022
7N9K
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BU of 7n9k by Molmil
KirBac3.1 L124M mutant
Descriptor: 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, Inward rectifier potassium channel Kirbac3.1, N-OCTANE, ...
Authors:Black, T.A, Gulbis, J.M.
Deposit date:2021-06-18
Release date:2021-12-29
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.72 Å)
Cite:Ion currents through Kir potassium channels are gated by anionic lipids.
Nat Commun, 13, 2022

 

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