PDB: 278 件ウェブページステータス検索Chemie searchBIRD

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6P2U	Structure of Mortalin-NBD with N6-propargyladenosine-5'-diphosphate 分子名称: 9-{5-O-[(S)-hydroxy(phosphonooxy)phosphoryl]-alpha-D-ribofuranosyl}-N-(prop-2-yn-1-yl)-9H-purin-6-amine, MAGNESIUM ION, PHOSPHATE ION, ... 著者 Moseng, M.A, Page, R.C. 登録日 2019-05-22 公開日 2019-06-19 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 2- and N6-functionalized adenosine-5'-diphosphate analogs for the inhibition of mortalin. Febs Lett., 593, 2019
1QQN	D206S MUTANT OF BOVINE 70 KILODALTON HEAT SHOCK PROTEIN 分子名称: ADENOSINE-5'-DIPHOSPHATE, CHLORIDE ION, D206S MUTANT OF BOVINE 70 KILODALTON HEAT SHOCK PROTEIN, ... 著者 Johnson, E.R, McKay, D.B. 登録日 1999-06-07 公開日 1999-09-15 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Mapping the role of active site residues for transducing an ATP-induced conformational change in the bovine 70-kDa heat shock cognate protein. Biochemistry, 38, 1999
6NHK	Mortalin nucleotide binding domain in the ADP-bound state 分子名称: ADENOSINE-5'-DIPHOSPHATE, GLYCEROL, MAGNESIUM ION, ... 著者 Page, R.C, Moseng, M.A, Nix, J.C. 登録日 2018-12-23 公開日 2019-04-17 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.777 Å) 主引用文献 Biophysical Consequences of EVEN-PLUS Syndrome Mutations for the Function of Mortalin. J.Phys.Chem.B, 123, 2019
2KHO	NMR-RDC / XRAY structure of E. coli HSP70 (DNAK) chaperone (1-605) complexed with ADP and substrate 分子名称: Heat shock protein 70 著者 Zuiderweg, E.R.P, Bertelsen, E.B. 登録日 2009-04-10 公開日 2009-05-12 最終更新日 2024-05-22 実験手法 SOLUTION NMR 主引用文献 Solution conformation of wild-type E. coli Hsp70 (DnaK) chaperone complexed with ADP and substrate. Proc.Natl.Acad.Sci.USA, 106, 2009
5FPE	Structure of heat shock-related 70kDA protein 2 with small-molecule ligand 1H-1,2,4-triazol-3-amine (AT485) in an alternate binding site. 分子名称: 3-AMINO-1,2,4-TRIAZOLE, HEAT SHOCK-RELATED 70KDA PROTEIN 2 著者 Jhoti, H, Ludlow, R.F, Patel, S, Saini, H.K, Tickle, I.J, Verdonk, M. 登録日 2015-11-28 公開日 2015-12-23 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.96 Å) 主引用文献 Detection of Secondary Binding Sites in Proteins Using Fragment Screening. Proc.Natl.Acad.Sci.USA, 112, 2015
5MKR	HSP72-NBD bound to compound TCI 8 - Tyr15 in up-conformation 分子名称: 3-[(2~{R},3~{S},4~{R},5~{R})-5-[6-azanyl-8-[(4-chlorophenyl)methylamino]purin-9-yl]-3,4-bis(oxidanyl)oxolan-2-yl]propyl prop-2-enoate, CITRATE ANION, Heat shock 70 kDa protein 1A 著者 Pettinger, J, Westwood, I.M, Cronin, N, Le Bihan, Y.-V, Van Montfort, R.L.M. 登録日 2016-12-05 公開日 2017-03-01 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (1.87 Å) 主引用文献 An Irreversible Inhibitor of HSP72 that Unexpectedly Targets Lysine-56. Angew. Chem. Int. Ed. Engl., 56, 2017
5FPD	Structure of heat shock-related 70kDA protein 2 with small-molecule ligand pyrazine-2-carboxamide (AT513) in an alternate binding site. 分子名称: HEAT SHOCK-RELATED 70KDA PROTEIN 2, PYRAZINE-2-CARBOXAMIDE 著者 Jhoti, H, Ludlow, R.F, Patel, S, Saini, H.K, Tickle, I.J, Verdonk, M. 登録日 2015-11-28 公開日 2015-12-16 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.97 Å) 主引用文献 Detection of Secondary Binding Sites in Proteins Using Fragment Screening. Proc.Natl.Acad.Sci.USA, 112, 2015
5MB9	Crystal structure of the eukaryotic ribosome associated complex (RAC), a unique Hsp70/Hsp40 pair 分子名称: ADENOSINE-5'-TRIPHOSPHATE, GLYCEROL, MAGNESIUM ION, ... 著者 Gumiero, A, Weyer, F.A, Valentin Gese, G, Lapouge, K, Sinning, I. 登録日 2016-11-07 公開日 2016-12-28 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (3.2 Å) 主引用文献 Structural insights into a unique Hsp70-Hsp40 interaction in the eukaryotic ribosome-associated complex. Nat. Struct. Mol. Biol., 24, 2017
5GJJ	Glutathionylated hHsp70 SBD 分子名称: Heat shock 70 kDa protein 1A 著者 Gong, W.B, Yang, J, Zhang, H, Perrett, S. 登録日 2016-06-30 公開日 2017-07-05 最終更新日 2023-06-14 実験手法 SOLUTION NMR 主引用文献 Structure of glutathionylated hHsp70 SBD (385-641) To Be Published
1U00	HscA substrate binding domain complexed with the IscU recognition peptide ELPPVKIHC 分子名称: Chaperone protein hscA, IscU recognition peptide 著者 Cupp-Vickery, J.R, Peterson, J.C, Ta, D.T, Vickery, L.E. 登録日 2004-07-12 公開日 2004-10-05 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Crystal Structure of the Molecular Chaperone HscA Substrate Binding Domain Complexed with the IscU Recognition Peptide ELPPVKIHC. J.Mol.Biol., 342, 2004
1S3X	The crystal structure of the human Hsp70 ATPase domain 分子名称: ADENOSINE-5'-DIPHOSPHATE, CALCIUM ION, Heat shock 70 kDa protein 1, ... 著者 Sriram, M, Osipiuk, J, Freeman, B, Morimoto, R.I, Joachimiak, A. 登録日 2004-01-14 公開日 2004-01-20 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (1.84 Å) 主引用文献 Human Hsp70 molecular chaperone binds two calcium ions within the ATPase domain Structure, 5, 1997
5FPM	Structure of heat shock-related 70kDA protein 2 with small-molecule ligand 5-phenyl-1,3,4-oxadiazole-2-thiol (AT809) in an alternate binding site. 分子名称: 5-PHENYL-1,3,4-OXADIAZOLE-2-THIOL, HEAT SHOCK-RELATED 70KDA PROTEIN 2 著者 Jhoti, H, Ludlow, R.F, Patel, S, Saini, H.K, Tickle, I.J, Verdonk, M. 登録日 2015-12-02 公開日 2015-12-16 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.96 Å) 主引用文献 Detection of Secondary Binding Sites in Proteins Using Fragment Screening. Proc.Natl.Acad.Sci.USA, 112, 2015
5TKY	Crystal structure of the co-translational Hsp70 chaperone Ssb in the ATP-bound, open conformation 分子名称: ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Putative uncharacterized protein 著者 Gumiero, A, Gese, G.V, Weyer, F.A, Lapouge, K, Sinning, I. 登録日 2016-10-10 公開日 2016-11-16 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Interaction of the cotranslational Hsp70 Ssb with ribosomal proteins and rRNA depends on its lid domain. Nat Commun, 7, 2016
4B9Q	Open conformation of ATP-bound Hsp70 homolog DnaK 分子名称: ADENOSINE-5'-TRIPHOSPHATE, CHAPERONE PROTEIN DNAK, MAGNESIUM ION 著者 Kopp, J, Mayer, M.P, Sinning, I. 登録日 2012-09-06 公開日 2012-11-14 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Structure and Dynamics of the ATP-Bound Open Conformation of Hsp70 Chaperones Mol.Cell, 48, 2012
6SR6	Crystal structure of the RAC core with a pseudo substrate bound to Ssz1 SBD 分子名称: ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Putative heat shock protein, ... 著者 Valentin Gese, G, Lapouge, K, Kopp, J, Sinning, I. 登録日 2019-09-05 公開日 2020-03-25 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 The ribosome-associated complex RAC serves in a relay that directs nascent chains to Ssb. Nat Commun, 11, 2020
5UMB	Crystal structure of ATPase domain of Malaria GRP78 with ADP bound 分子名称: ADENOSINE-5'-DIPHOSPHATE, Chaperone DnaK, MAGNESIUM ION, ... 著者 Chen, Y, Antoshchenko, T, Pizarro, J.C, Song, J.H, Park, H. 登録日 2017-01-26 公開日 2022-07-27 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Repurposing drugs to target the malaria parasite unfolding protein response. Sci Rep, 8, 2018
1YUW	crystal structure of bovine hsc70(aa1-554)E213A/D214A mutant 分子名称: Heat shock cognate 71 kDa protein 著者 Jiang, J, Lafer, E.M, Prasad, K, Sousa, R. 登録日 2005-02-14 公開日 2005-10-04 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Structural basis of interdomain communication in the Hsc70 chaperone Mol.Cell, 20, 2005
7Q4R	Crystal structure of human HSP72-NBD in complex with fragment 1 分子名称: 4-(4-phenyl-1,3-thiazol-2-yl)piperazine-1-carboxamide, Heat shock 70 kDa protein 1A, MAGNESIUM ION, ... 著者 Le Bihan, Y.V, Westwood, I.M, van Montfort, R.L.M. 登録日 2021-11-02 公開日 2022-02-02 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.79 Å) 主引用文献 Discovery and Characterization of a Cryptic Secondary Binding Site in the Molecular Chaperone HSP70. Molecules, 27, 2022
6PMT	Structure of Mortalin-NBD with adenosine-5'-monophosphate and thiodiphosphate 分子名称: ADENOSINE MONOPHOSPHATE, PHOSPHATE ION, Stress-70 protein, ... 著者 Moseng, M.A, Nix, J.C, Page, R.C. 登録日 2019-07-02 公開日 2020-07-08 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Structure of the mortalin nucleotide binding domain in complex with adenosine monophosphate to be published
7PLK	Crystal structure bovine Hsc70(aa1-554)E213A/D214A in complex with nicotinic-acid-derivative 分子名称: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, 5-pyrrol-1-ylpyridine-3-carboxylic acid, GLYCEROL, ... 著者 Zehe, M, Grimm, C, Sotriffer, C. 登録日 2021-08-31 公開日 2022-09-07 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2.48781371 Å) 主引用文献 Combined In-Solution Fragment Screening and Crystallographic Binding-Mode Analysis with a Two-Domain Hsp70 Construct. Acs Chem.Biol., 2024
7RAX	ATP-binding state of the nucleotide-binding domain of Hsp70 DnaK mutant T199A 分子名称: ADENOSINE-5'-TRIPHOSPHATE, Chaperone protein DnaK, GLYCEROL, ... 著者 Wang, W, Hendrickson, W.A. 登録日 2021-07-04 公開日 2023-07-05 最終更新日 2024-07-17 実験手法 X-RAY DIFFRACTION (1.41 Å) 主引用文献 Conformational equilibria in allosteric control of Hsp70 chaperones. Mol.Cell, 81, 2021
6S02	Plasmodium falciparum Hsp70-x chaperone nucleotide binding domain - ADP bound state 分子名称: ADENOSINE-5'-DIPHOSPHATE, Heat shock protein 70, MAGNESIUM ION 著者 Vakonakis, I, Day, J. 登録日 2019-06-13 公開日 2019-10-02 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.87 Å) 主引用文献 ThePlasmodium falciparumHsp70-x chaperone assists the heat stress response of the malaria parasite. Faseb J., 33, 2019
6RZQ	Plasmodium falciparum Hsp70-x chaperone nucleotide binding domain - ANP-PnP bound state 分子名称: GLYCEROL, Heat shock protein 70, MAGNESIUM ION, ... 著者 Vakonakis, I, Day, J. 登録日 2019-06-13 公開日 2019-10-02 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.81 Å) 主引用文献 ThePlasmodium falciparumHsp70-x chaperone assists the heat stress response of the malaria parasite. Faseb J., 33, 2019
1DKZ	THE SUBSTRATE BINDING DOMAIN OF DNAK IN COMPLEX WITH A SUBSTRATE PEPTIDE, DETERMINED FROM TYPE 1 NATIVE CRYSTALS 分子名称: SUBSTRATE BINDING DOMAIN OF DNAK, SUBSTRATE PEPTIDE (7 RESIDUES) 著者 Zhu, X, Zhao, X, Burkholder, W.F, Gragerov, A, Ogata, C.M, Gottesman, M.E, Hendrickson, W.A. 登録日 1996-06-03 公開日 1996-12-07 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Structural analysis of substrate binding by the molecular chaperone DnaK. Science, 272, 1996
2BPR	NMR STRUCTURE OF THE SUBSTRATE BINDING DOMAIN OF DNAK, 25 STRUCTURES 分子名称: DNAK 著者 Wang, H, Kurochkin, A.V, Pang, Y, Hu, W, Flynn, G.C, Zuiderweg, E.R.P. 登録日 1998-08-11 公開日 1999-03-02 最終更新日 2024-05-22 実験手法 SOLUTION NMR 主引用文献 NMR solution structure of the 21 kDa chaperone protein DnaK substrate binding domain: a preview of chaperone-protein interaction. Biochemistry, 37, 1998

 

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