1RW2
| Three-dimensional structure of Ku80 CTD | 分子名称: | ATP-dependent DNA helicase II, 80 kDa subunit | 著者 | Zhang, Z, Hu, W, Cano, L, Lee, T.D, Chen, D.J, Chen, Y. | 登録日 | 2003-12-15 | 公開日 | 2003-12-30 | 最終更新日 | 2024-05-22 | 実験手法 | SOLUTION NMR | 主引用文献 | Solution structure of the C-terminal domain of Ku80 suggests important sites for protein-protein interactions. STRUCTURE, 12, 2004
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1Q2Z
| The 3D solution structure of the C-terminal region of Ku86 | 分子名称: | ATP-dependent DNA helicase II, 80 kDa subunit | 著者 | Harris, R, Esposito, D, Sankar, A, Maman, J.D, Hinks, J.A, Pearl, L.H, Driscoll, P.C. | 登録日 | 2003-07-28 | 公開日 | 2004-01-13 | 最終更新日 | 2024-05-22 | 実験手法 | SOLUTION NMR | 主引用文献 | The 3D Solution Structure of the C-terminal Region of Ku86 (Ku86CTR) J.Mol.Biol., 335, 2004
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7K17
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7SGL
| DNA-PK complex of DNA end processing | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, DNA-dependent protein kinase catalytic subunit, Hairpin_1, ... | 著者 | Liu, L, Li, J, Chen, X, Yang, W, Gellert, M. | 登録日 | 2021-10-06 | 公開日 | 2022-01-12 | 最終更新日 | 2022-01-19 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Autophosphorylation transforms DNA-PK from protecting to processing DNA ends. Mol.Cell, 82, 2022
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7AXZ
| Ku70/80 complex apo form | 分子名称: | X-ray repair cross-complementing protein 5, X-ray repair cross-complementing protein 6 | 著者 | Hnizda, A, Tesina, P, Novak, P, Blundell, T.L. | 登録日 | 2020-11-10 | 公開日 | 2021-02-10 | 最終更新日 | 2024-05-01 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | SAP domain forms a flexible part of DNA aperture in Ku70/80. Febs J., 288, 2021
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3ISM
| Crystal structure of the EndoG/EndoGI complex: Mechanism of EndoG inhibition | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CG4930, CG8862, ... | 著者 | Loll, B, Gebhardt, M, Wahle, E, Meinhart, A. | 登録日 | 2009-08-26 | 公開日 | 2009-09-08 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Crystal structure of the EndoG/EndoGI complex: mechanism of EndoG inhibition. Nucleic Acids Res., 37, 2009
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7SU3
| CryoEM structure of DNA-PK complex VII | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, DNA (5'-D(*AP*AP*GP*CP*AP*GP*TP*AP*GP*AP*G)-3'), DNA (5'-D(*GP*CP*AP*TP*GP*CP*TP*CP*TP*AP*CP*TP*GP*CP*TP*TP*CP*GP*AP*TP*AP*TP*CP*G)-3'), ... | 著者 | Chen, X, Liu, L, Gellert, M, Yang, W. | 登録日 | 2021-11-16 | 公開日 | 2022-01-12 | 最終更新日 | 2024-06-05 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Autophosphorylation transforms DNA-PK from protecting to processing DNA ends. Mol.Cell, 82, 2022
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7SUD
| CryoEM structure of DNA-PK complex VIII | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, DNA-dependent protein kinase catalytic subunit, MAGNESIUM ION, ... | 著者 | Chen, X, Liu, L, Gellert, M, Yang, W. | 登録日 | 2021-11-16 | 公開日 | 2022-01-12 | 最終更新日 | 2022-01-19 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | Autophosphorylation transforms DNA-PK from protecting to processing DNA ends. Mol.Cell, 82, 2022
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8EZB
| NHEJ Long-range complex with ATP | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, DNA (30-MER), DNA (31-MER), ... | 著者 | Chen, S, He, Y. | 登録日 | 2022-10-31 | 公開日 | 2023-06-14 | 最終更新日 | 2024-06-19 | 実験手法 | ELECTRON MICROSCOPY (8.9 Å) | 主引用文献 | Cryo-EM visualization of DNA-PKcs structural intermediates in NHEJ. Sci Adv, 9, 2023
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8EZA
| NHEJ Long-range complex with PAXX | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, DNA (30-MER), DNA (31-MER), ... | 著者 | Chen, S, He, Y. | 登録日 | 2022-10-31 | 公開日 | 2023-06-14 | 最終更新日 | 2024-06-19 | 実験手法 | ELECTRON MICROSCOPY (4.39 Å) | 主引用文献 | Cryo-EM visualization of DNA-PKcs structural intermediates in NHEJ. Sci Adv, 9, 2023
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8BH3
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8BHV
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8BHY
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6ZHE
| Cryo-EM structure of DNA-PK dimer | 分子名称: | DNA (25-MER), DNA (26-MER), DNA (27-MER), ... | 著者 | Chaplin, A.K, Hardwick, S.W, Chirgadze, D.Y, Blundell, T.L. | 登録日 | 2020-06-23 | 公開日 | 2020-10-21 | 最終更新日 | 2024-05-01 | 実験手法 | ELECTRON MICROSCOPY (7.24 Å) | 主引用文献 | Dimers of DNA-PK create a stage for DNA double-strand break repair. Nat.Struct.Mol.Biol., 28, 2021
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6ZH6
| Cryo-EM structure of DNA-PKcs:Ku80ct194 | 分子名称: | DNA-dependent protein kinase catalytic subunit,DNA-PKcs, X-ray repair cross-complementing protein 5 | 著者 | Chaplin, A.K, Hardwick, S.W, Chirgadze, D.Y, Blundell, T.L. | 登録日 | 2020-06-21 | 公開日 | 2020-10-21 | 最終更新日 | 2024-05-01 | 実験手法 | ELECTRON MICROSCOPY (3.93 Å) | 主引用文献 | Dimers of DNA-PK create a stage for DNA double-strand break repair. Nat.Struct.Mol.Biol., 28, 2021
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6ZHA
| Cryo-EM structure of DNA-PK monomer | 分子名称: | DNA, DNA-dependent protein kinase catalytic subunit,DNA-dependent protein kinase catalytic subunit,DNA-dependent protein kinase catalytic subunit,DNA-PKcs, X-ray repair cross-complementing protein 5, ... | 著者 | Chaplin, A.K, Hardwick, S.W, Chirgadze, D.Y, Blundell, T.L. | 登録日 | 2020-06-21 | 公開日 | 2020-10-21 | 最終更新日 | 2024-05-01 | 実験手法 | ELECTRON MICROSCOPY (3.91 Å) | 主引用文献 | Dimers of DNA-PK create a stage for DNA double-strand break repair. Nat.Struct.Mol.Biol., 28, 2021
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7LSY
| NHEJ Short-range synaptic complex | 分子名称: | DNA (26-MER), DNA (5'-D(P*CP*AP*AP*TP*GP*AP*AP*AP*CP*GP*GP*AP*AP*CP*AP*GP*TP*CP*AP*G)-3'), DNA (5'-D(P*GP*TP*TP*CP*TP*TP*AP*GP*TP*AP*TP*AP*TP*A)-3'), ... | 著者 | He, Y, Chen, S. | 登録日 | 2021-02-18 | 公開日 | 2021-04-14 | 最終更新日 | 2023-08-16 | 実験手法 | ELECTRON MICROSCOPY (8.4 Å) | 主引用文献 | Structural basis of long-range to short-range synaptic transition in NHEJ. Nature, 593, 2021
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7NFC
| Cryo-EM structure of NHEJ super-complex (dimer) | 分子名称: | DNA (27-MER), DNA (28-MER), DNA ligase 4, ... | 著者 | Chaplin, A.K, Hardwick, S.W, Kefala Stavridi, A, Chirgadze, D.Y, Blundell, T.L. | 登録日 | 2021-02-05 | 公開日 | 2021-08-18 | 最終更新日 | 2024-07-10 | 実験手法 | ELECTRON MICROSCOPY (4.14 Å) | 主引用文献 | Cryo-EM of NHEJ supercomplexes provides insights into DNA repair. Mol.Cell, 81, 2021
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7NFE
| Cryo-EM structure of NHEJ super-complex (monomer) | 分子名称: | DNA (5'-D(P*AP*AP*TP*AP*AP*AP*CP*TP*AP*AP*AP*AP*AP*CP*TP*AP*TP*TP*AP*TP*TP*AP*TP*G)-3'), DNA (5'-D(P*TP*AP*AP*TP*AP*AP*TP*AP*GP*TP*TP*TP*TP*TP*AP*GP*TP*TP*TP*AP*TP*TP*AP*G)-3'), DNA ligase 4, ... | 著者 | Chaplin, A.K, Hardwick, S.W, Kefala Stavridi, A, Chirgadze, D.Y, Blundell, T.L. | 登録日 | 2021-02-06 | 公開日 | 2021-08-18 | 最終更新日 | 2024-07-10 | 実験手法 | ELECTRON MICROSCOPY (4.29 Å) | 主引用文献 | Cryo-EM of NHEJ supercomplexes provides insights into DNA repair. Mol.Cell, 81, 2021
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7LT3
| NHEJ Long-range synaptic complex | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, DNA (30-MER), DNA (31-MER), ... | 著者 | He, Y, Chen, S. | 登録日 | 2021-02-18 | 公開日 | 2021-04-14 | 最終更新日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (4.6 Å) | 主引用文献 | Structural basis of long-range to short-range synaptic transition in NHEJ. Nature, 593, 2021
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7K0Y
| Cryo-EM structure of activated-form DNA-PK (complex VI) | 分子名称: | DNA (5'-D(*AP*AP*GP*CP*AP*GP*TP*AP*GP*AP*GP*CP*A)-3'), DNA (5'-D(*GP*CP*AP*TP*GP*CP*TP*CP*TP*AP*CP*TP*GP*CP*TP*TP*CP*GP*AP*TP*AP*TP*CP*G)-3'), DNA-dependent protein kinase catalytic subunit, ... | 著者 | Chen, X, Gellert, M, Yang, W. | 登録日 | 2020-09-06 | 公開日 | 2021-01-06 | 最終更新日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | 主引用文献 | Structure of an activated DNA-PK and its implications for NHEJ. Mol.Cell, 81, 2021
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7K1J
| CryoEM structure of inactivated-form DNA-PK (Complex III) | 分子名称: | DNA (5'-D(*AP*AP*GP*CP*AP*GP*TP*AP*GP*AP*GP*CP*A)-3'), DNA (5'-D(*GP*CP*AP*TP*GP*CP*TP*CP*TP*AP*CP*TP*GP*CP*TP*TP*CP*GP*AP*TP*AP*TP*CP*G)-3'), DNA-dependent protein kinase catalytic subunit, ... | 著者 | Chen, X, Gellert, M, Yang, W. | 登録日 | 2020-09-07 | 公開日 | 2021-01-06 | 最終更新日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | 主引用文献 | Structure of an activated DNA-PK and its implications for NHEJ. Mol.Cell, 81, 2021
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7K1N
| CryoEM structure of inactivated-form DNA-PK (Complex V) | 分子名称: | DNA (5'-D(P*AP*AP*GP*CP*AP*GP*TP*AP*GP*AP*GP*CP*A)-3'), DNA (5'-D(P*GP*CP*AP*TP*GP*CP*TP*CP*TP*AP*CP*TP*GP*CP*TP*TP*CP*GP*AP*TP*AP*TP*CP*G)-3'), DNA-dependent protein kinase catalytic subunit, ... | 著者 | Chen, X, Gellert, M, Yang, W. | 登録日 | 2020-09-08 | 公開日 | 2021-01-06 | 最終更新日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | 主引用文献 | Structure of an activated DNA-PK and its implications for NHEJ. Mol.Cell, 81, 2021
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7K1K
| CryoEM structure of inactivated-form DNA-PK (Complex IV) | 分子名称: | DNA (5'-D(*AP*AP*GP*CP*AP*GP*TP*AP*GP*AP*GP*CP*A)-3'), DNA (5'-D(*GP*CP*AP*TP*GP*CP*TP*CP*TP*AP*CP*TP*GP*CP*TP*TP*CP*GP*AP*TP*AP*TP*CP*G)-3'), DNA-dependent protein kinase catalytic subunit, ... | 著者 | Chen, X, Gellert, M, Yang, W. | 登録日 | 2020-09-07 | 公開日 | 2021-01-06 | 最終更新日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (4.1 Å) | 主引用文献 | Structure of an activated DNA-PK and its implications for NHEJ. Mol.Cell, 81, 2021
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7Z88
| DNA-PK in the intermediate state | 分子名称: | (~{S})-[2-chloranyl-4-fluoranyl-5-(7-morpholin-4-ylquinazolin-4-yl)phenyl]-(6-methoxypyridazin-3-yl)methanol, DNA (26-MER), DNA-dependent protein kinase catalytic subunit, ... | 著者 | Liang, S, Blundell, T.L. | 登録日 | 2022-03-16 | 公開日 | 2023-01-18 | 最終更新日 | 2024-07-24 | 実験手法 | ELECTRON MICROSCOPY (3.33 Å) | 主引用文献 | Human DNA-dependent protein kinase activation mechanism. Nat.Struct.Mol.Biol., 30, 2023
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