6Z1S
 
 | | Structure of Polyphenol Oxidase (mutant G292N) from Thermothelomyces thermophila | | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Dimarogona, M, Nikolaivits, E, Valmas, A, Topakas, E. | | 登録日 | 2020-05-14 | | 公開日 | 2021-03-24 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (1.53 Å) | | 主引用文献 | Considerations Regarding Activity Determinants of Fungal Polyphenol Oxidases Based on Mutational and Structural Studies.
Appl.Environ.Microbiol., 87, 2021
|
|
8HPI
 | |
6QXD
 | | Crystal Structure of tyrosinase from Bacillus megaterium with JKB inhibitor in the active site. | | 分子名称: | (2,4-dinitrophenyl)-[4-[(4-fluorophenyl)methyl]piperazin-1-yl]methanone, COPPER (II) ION, Tyrosinase | | 著者 | Deri Zenaty, B, Gitto, R, Pazy, Y, Fishman, A. | | 登録日 | 2019-03-07 | | 公開日 | 2019-06-19 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (2.317 Å) | | 主引用文献 | Exploiting the 1-(4-fluorobenzyl)piperazine fragment for the development of novel tyrosinase inhibitors as anti-melanogenic agents: Design, synthesis, structural insights and biological profile.
Eur.J.Med.Chem., 178, 2019
|
|
6EI4
 | | Crystal Structure of tyrosinase from Bacillus megaterium with B5N inhibitor in the active site | | 分子名称: | COPPER (II) ION, Tyrosinase, [4-[(4-fluorophenyl)methyl]piperazin-1-yl]-(2-methylphenyl)methanone | | 著者 | Deri, B, Gitto, R, Pazy Benhar, Y, Fishman, A. | | 登録日 | 2017-09-17 | | 公開日 | 2018-04-25 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Targeting Tyrosinase: Development and Structural Insights of Novel Inhibitors Bearing Arylpiperidine and Arylpiperazine Fragments.
J. Med. Chem., 61, 2018
|
|
4D87
 | |
5I3A
 | | Crystal Structure of tyrosinase from Bacillus megaterium with configuration A of hydroquinone inhibitor in the active site | | 分子名称: | Tyrosinase, ZINC ION, benzene-1,4-diol | | 著者 | Kanteev, M, Deri, B, Adir, N, Fishman, A. | | 登録日 | 2016-02-10 | | 公開日 | 2016-10-12 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | The unravelling of the complex pattern of tyrosinase inhibition.
Sci Rep, 6, 2016
|
|
6GSG
 | | Crystal structure of Aspergillus oryzae catechol oxidase complexed with resorcinol | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, COPPER (II) ION, Catechol oxidase, ... | | 著者 | Penttinen, L, Hakulinen, N, Rouvinen, J. | | 登録日 | 2018-06-14 | | 公開日 | 2018-09-19 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (2.192 Å) | | 主引用文献 | Unraveling Substrate Specificity and Catalytic Promiscuity of Aspergillus oryzae Catechol Oxidase.
Chembiochem, 19, 2018
|
|
5I3B
 | | Crystal Structure of tyrosinase from Bacillus megaterium with configuration B of hydroquinone inhibitor in the active site | | 分子名称: | Tyrosinase, ZINC ION, benzene-1,4-diol | | 著者 | Kanteev, M, Deri, B, Adir, N, Fishman, A. | | 登録日 | 2016-02-10 | | 公開日 | 2016-10-12 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | The unravelling of the complex pattern of tyrosinase inhibition.
Sci Rep, 6, 2016
|
|
4P6S
 | | Crystal Structure of tyrosinase from Bacillus megaterium with L-DOPA in the active site | | 分子名称: | 3,4-DIHYDROXYPHENYLALANINE, Tyrosinase, ZINC ION | | 著者 | Goldfeder, M, Kanteev, M, Adir, N, Fishman, A. | | 登録日 | 2014-03-25 | | 公開日 | 2014-07-30 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Determination of tyrosinase substrate-binding modes reveals mechanistic differences between type-3 copper proteins.
Nat Commun, 5, 2014
|
|
4P6R
 | | Crystal Structure of tyrosinase from Bacillus megaterium with tyrosine in the active site | | 分子名称: | TYROSINE, Tyrosinase, ZINC ION | | 著者 | Goldfeder, M, Kanteev, M, Adir, N, Fishman, A. | | 登録日 | 2014-03-25 | | 公開日 | 2014-07-30 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Determination of tyrosinase substrate-binding modes reveals mechanistic differences between type-3 copper proteins.
Nat Commun, 5, 2014
|
|
5I38
 | | Crystal Structure of tyrosinase from Bacillus megaterium with inhibitor kojic acid in the active site | | 分子名称: | 5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE, COPPER (II) ION, Tyrosinase | | 著者 | Kanteev, M, Goldfeder, M, Deri, B, Adir, N, Fishman, A. | | 登録日 | 2016-02-10 | | 公開日 | 2016-10-12 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | The unravelling of the complex pattern of tyrosinase inhibition.
Sci Rep, 6, 2016
|
|
4P6T
 | | Crystal Structure of tyrosinase from Bacillus megaterium with p-tyrosol in the active site | | 分子名称: | 4-(2-hydroxyethyl)phenol, COPPER (II) ION, Tyrosinase | | 著者 | Goldfeder, M, Kanteev, M, Adir, N, Fishman, A. | | 登録日 | 2014-03-25 | | 公開日 | 2014-07-30 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Determination of tyrosinase substrate-binding modes reveals mechanistic differences between type-3 copper proteins.
Nat Commun, 5, 2014
|
|
4HD7
 | | Crystal Structure of Tyrosinase from Bacillus megaterium V218G mutant soaked in CuSO4 | | 分子名称: | COPPER (II) ION, Tyrosinase | | 著者 | Goldfeder, M, Kanteev, M, Adir, N, Fishman, A. | | 登録日 | 2012-10-02 | | 公開日 | 2013-01-23 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Influencing the monophenolase/diphenolase activity ratio in tyrosinase.
Biochim.Biophys.Acta, 1834, 2013
|
|
4HD4
 | | Crystal Structure of Tyrosinase from Bacillus megaterium V218F mutant | | 分子名称: | COPPER (II) ION, Tyrosinase | | 著者 | Goldfeder, M, Kanteev, M, Adir, N, Fishman, A. | | 登録日 | 2012-10-02 | | 公開日 | 2013-01-23 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Influencing the monophenolase/diphenolase activity ratio in tyrosinase.
Biochim.Biophys.Acta, 1834, 2013
|
|
4HD6
 | | Crystal Structure of Tyrosinase from Bacillus megaterium V218F mutant soaked in CuSO4 | | 分子名称: | COPPER (II) ION, Tyrosinase | | 著者 | Goldfeder, M, Kanteev, M, Adir, N, Fishman, A. | | 登録日 | 2012-10-02 | | 公開日 | 2013-01-23 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Influencing the monophenolase/diphenolase activity ratio in tyrosinase.
Biochim.Biophys.Acta, 1834, 2013
|
|
9EY8
 | |
9EY5
 | |
9EY6
 | | Crystal structure of human tyrosinase-related protein 1 (TYRP1) | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, 5,6-dihydroxyindole-2-carboxylic acid oxidase, ... | | 著者 | Ng, Y.M, Soler-Lopez, M. | | 登録日 | 2024-04-09 | | 公開日 | 2024-05-22 | | 最終更新日 | 2024-07-03 | | 実験手法 | X-RAY DIFFRACTION (2.228 Å) | | 主引用文献 | Interactions of Phenylalanine Derivatives with Human Tyrosinase: Lessons from Experimental and Theoretical tudies.
Chembiochem, 25, 2024
|
|
9EY7
 | |
5M8N
 | | Crystal structure of human tyrosinase related protein 1 in complex with mimosine | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Lai, X, Soler-Lopez, M, Wichers, H.J, Dijkstra, B.W. | | 登録日 | 2016-10-29 | | 公開日 | 2017-07-12 | | 最終更新日 | 2020-07-29 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Structure of Human Tyrosinase Related Protein 1 Reveals a Binuclear Zinc Active Site Important for Melanogenesis.
Angew. Chem. Int. Ed. Engl., 56, 2017
|
|
5M8M
 | | Crystal structure of human tyrosinase related protein 1 in complex with kojic acid | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Lai, X, Soler-Lopez, M, Wichers, H.J, Dijkstra, B.W. | | 登録日 | 2016-10-29 | | 公開日 | 2017-07-12 | | 最終更新日 | 2020-07-29 | | 実験手法 | X-RAY DIFFRACTION (2.65 Å) | | 主引用文献 | Structure of Human Tyrosinase Related Protein 1 Reveals a Binuclear Zinc Active Site Important for Melanogenesis.
Angew. Chem. Int. Ed. Engl., 56, 2017
|
|
5M8Q
 | | Crystal structure of human tyrosinase related protein 1 mutant (T391V-R374S-Y362F) in complex with kojic acid | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Lai, X, Soler-Lopez, M, Wichers, H.J, Dijkstra, B.W. | | 登録日 | 2016-10-29 | | 公開日 | 2017-07-12 | | 最終更新日 | 2020-07-29 | | 実験手法 | X-RAY DIFFRACTION (2.85 Å) | | 主引用文献 | Structure of Human Tyrosinase Related Protein 1 Reveals a Binuclear Zinc Active Site Important for Melanogenesis.
Angew. Chem. Int. Ed. Engl., 56, 2017
|
|
5M8P
 | | Crystal structure of human tyrosinase related protein 1 in complex with tyrosine | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-3)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Lai, X, Soler-Lopez, M, Wichers, H.J, Dijkstra, B.W. | | 登録日 | 2016-10-29 | | 公開日 | 2017-07-12 | | 最終更新日 | 2022-12-07 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Structure of Human Tyrosinase Related Protein 1 Reveals a Binuclear Zinc Active Site Important for Melanogenesis.
Angew. Chem. Int. Ed. Engl., 56, 2017
|
|
5M8T
 | | Crystal structure of human tyrosinase related protein 1 (T391V-R374S-Y362F) in complex with tropolone | | 分子名称: | 2-HYDROXYCYCLOHEPTA-2,4,6-TRIEN-1-ONE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Lai, X, Soler-Lopez, M, Wichers, H.J, Dijkstra, B.W. | | 登録日 | 2016-10-29 | | 公開日 | 2017-07-12 | | 最終更新日 | 2020-07-29 | | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | | 主引用文献 | Structure of Human Tyrosinase Related Protein 1 Reveals a Binuclear Zinc Active Site Important for Melanogenesis.
Angew. Chem. Int. Ed. Engl., 56, 2017
|
|
5M8O
 | | Crystal structure of human tyrosinase related protein 1 in complex with tropolone | | 分子名称: | 2-HYDROXYCYCLOHEPTA-2,4,6-TRIEN-1-ONE, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Lai, X, Soler-Lopez, M, Wichers, H.J, Dijkstra, B.W. | | 登録日 | 2016-10-29 | | 公開日 | 2017-07-12 | | 最終更新日 | 2020-07-29 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Structure of Human Tyrosinase Related Protein 1 Reveals a Binuclear Zinc Active Site Important for Melanogenesis.
Angew. Chem. Int. Ed. Engl., 56, 2017
|
|
