5M8M

Crystal structure of human tyrosinase related protein 1 in complex with kojic acid

Summary for 5M8M

• Entry DOI: 10.2210/pdb5m8m/pdb
• Descriptor: 5,6-dihydroxyindole-2-carboxylic acid oxidase, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... (11 entities in total)
• Functional Keywords: human tyrosinase related protein 1, melanin biosynthesis, tyrosinase, oxidoreductase, unknown function
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 4
• Total formula weight: 214037.88

Authors

Lai, X.,Soler-Lopez, M.,Wichers, H.J.,Dijkstra, B.W. (deposition date: 2016-10-29, release date: 2017-07-12, Last modification date: 2020-07-29)

• Primary citation: Lai, X.,Wichers, H.J.,Soler-Lopez, M.,Dijkstra, B.W.; Structure of Human Tyrosinase Related Protein 1 Reveals a Binuclear Zinc Active Site Important for Melanogenesis.; Angew. Chem. Int. Ed. Engl., 56:9812-9815, 2017; PubMed: 28661582; DOI: 10.1002/anie.201704616

Experimental method

X-RAY DIFFRACTION (2.65 Å)