6I50
 
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8KB6
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7SGM
 | | Crystal structure of a Fab variant containing a fluorescent noncanonical amino acid with blocked excited state proton transfer and in complex with its antigen, CD40L | | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 5c8* Fab heavy chain, ... | | 著者 | Henderson, J.N, Mills, J.H, Simmons, C.R. | | 登録日 | 2021-10-06 | | 公開日 | 2022-02-02 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Structural Basis for Blocked Excited State Proton Transfer in a Fluorescent, Photoacidic Non-Canonical Amino Acid-Containing Antibody Fragment.
J.Mol.Biol., 434, 2022
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5MU8
 | | HUMAN TNF-ALPHA IN COMPLEX WITH JNJ525 | | 分子名称: | Tumor necrosis factor, ~{N}4-(phenylmethyl)-~{N}4-[2-[3-(2-piperazin-1-ylpyrimidin-5-yl)phenyl]phenyl]pyrimidine-2,4-diamine | | 著者 | Blevitt, J.M, Hack, M.D, Herman, K.L, Jackson, P.F, Krawczuk, P.J, Lebsack, A.D, Liu, A.X, Mirzadegan, T, Nelen, M.I, Patrick, A.P, Steinbacher, S, Milla, M.E, Lumb, K.J. | | 登録日 | 2017-01-12 | | 公開日 | 2017-03-29 | | 最終更新日 | 2019-02-20 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | Structural Basis of Small-Molecule Aggregate Induced Inhibition of a Protein-Protein Interaction.
J. Med. Chem., 60, 2017
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8SLR
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3WD5
 | | Crystal structure of TNFalpha in complex with Adalimumab Fab fragment | | 分子名称: | Adalimumab Heavy Chain, Adalimumab Light Chain, Tumor necrosis factor | | 著者 | Hu, S, Liang, S.Y, Guo, Y.J, Lou, Z.Y. | | 登録日 | 2013-06-06 | | 公開日 | 2013-08-14 | | 最終更新日 | 2015-07-01 | | 実験手法 | X-RAY DIFFRACTION (3.101 Å) | | 主引用文献 | Comparison of the inhibition mechanisms of adalimumab and infliximab in treating tumor necrosis factor alpha-associated diseases from a molecular view
J.Biol.Chem., 288, 2013
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7X9G
 | | Crystal structure of human EDA and EDAR | | 分子名称: | Ectodysplasin-A, secreted form, Tumor necrosis factor receptor superfamily member EDAR | | 著者 | Yu, K, Wan, F, Huang, C, Wu, J, Lei, M. | | 登録日 | 2022-03-15 | | 公開日 | 2023-02-22 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Structural insights into pathogenic mechanism of hypohidrotic ectodermal dysplasia caused by ectodysplasin A variants.
Nat Commun, 14, 2023
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8Z8M
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6ZT0
 | | Crystal structure of the Eiger TNF domain/Grindelwald extracellular domain complex | | 分子名称: | 1,2-ETHANEDIOL, Protein eiger, Protein grindelwald | | 著者 | Palmerini, V, Cecatiello, V, Pasqualato, S, Mapelli, M. | | 登録日 | 2020-07-17 | | 公開日 | 2021-03-03 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (2.02 Å) | | 主引用文献 | Drosophila TNFRs Grindelwald and Wengen bind Eiger with different affinities and promote distinct cellular functions.
Nat Commun, 12, 2021
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6RMJ
 | | Crystal structure of human NGR-TNF | | 分子名称: | Tumor necrosis factor | | 著者 | Degano, M, Garau, G. | | 登録日 | 2019-05-07 | | 公開日 | 2019-10-09 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (2.65 Å) | | 主引用文献 | Mechanism of Action of the Tumor Vessel Targeting Agent NGR-hTNF: Role of Both NGR Peptide and hTNF in Cell Binding and Signaling.
Int J Mol Sci, 20, 2019
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3FC0
 | | 1.8 A crystal structure of murine GITR ligand dimer expressed in Drosophila melanogaster S2 cells | | 分子名称: | ACETATE ION, GITR ligand | | 著者 | Chattopadhyay, K, Ramagopal, U.A, Nathenson, S.G, Almo, S.C. | | 登録日 | 2008-11-20 | | 公開日 | 2008-12-30 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (1.76 Å) | | 主引用文献 | 1.8 A structure of murine GITR ligand dimer expressed in Drosophila melanogaster S2 cells.
Acta Crystallogr.,Sect.D, 65, 2009
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7TA6
 | | Trimer-to-Monomer Disruption of Tumor Necrosis Factor-alpha (TNF-alpha) by unnatural alpha/beta-peptide-1 | | 分子名称: | 1,2-ETHANEDIOL, AMINO GROUP, Alpha/Beta-peptide-1, ... | | 著者 | Niu, J, Bingman, C.A, Gellman, S.H. | | 登録日 | 2021-12-20 | | 公開日 | 2022-06-29 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (2.67 Å) | | 主引用文献 | Trimer-to-Monomer Disruption Mechanism for a Potent, Protease-Resistant Antagonist of Tumor Necrosis Factor-alpha Signaling.
J.Am.Chem.Soc., 144, 2022
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1ALY
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7TA3
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1A8M
 | | TUMOR NECROSIS FACTOR ALPHA, R31D MUTANT | | 分子名称: | TUMOR NECROSIS FACTOR ALPHA | | 著者 | Reed, C, Fu, Z.-Q, Wu, J, Xue, Y.-N, Harrison, R.W, Chen, M.-J, Weber, I.T. | | 登録日 | 1998-03-27 | | 公開日 | 1998-06-17 | | 最終更新日 | 2023-08-02 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Crystal structure of TNF-alpha mutant R31D with greater affinity for receptor R1 compared with R2.
Protein Eng., 10, 1997
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6FXN
 | | Crystal structure of human BAFF in complex with Fab fragment of anti-BAFF antibody belimumab | | 分子名称: | Tumor necrosis factor ligand superfamily member 13B, belimumab heavy chain, belimumab light chain | | 著者 | Lammens, A, Maskos, K, Willen, L, Jiang, X, Schneider, P. | | 登録日 | 2018-03-09 | | 公開日 | 2018-04-04 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | A loop region of BAFF controls B cell survival and regulates recognition by different inhibitors.
Nat Commun, 9, 2018
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4ZCH
 | | Single-chain human APRIL-BAFF-BAFF Heterotrimer | | 分子名称: | TRIS-HYDROXYMETHYL-METHYL-AMMONIUM, Tumor necrosis factor ligand superfamily member 13,Tumor necrosis factor ligand superfamily member 13B,Tumor necrosis factor ligand superfamily member 13B | | 著者 | Lammens, A, Jiang, X, Maskos, K, Schneider, P. | | 登録日 | 2015-04-16 | | 公開日 | 2015-05-13 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (2.43 Å) | | 主引用文献 | Stoichiometry of Heteromeric BAFF and APRIL Cytokines Dictates Their Receptor Binding and Signaling Properties.
J.Biol.Chem., 290, 2015
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6FIB
 | | Structure of human 4-1BB ligand | | 分子名称: | Tumor necrosis factor ligand superfamily member 9, Tumor necrosis factor ligand superfamily member 9,4-1BBL -CH/CL fusion, Tumor necrosis factor ligand superfamily member 9,Uncharacterized protein | | 著者 | Joseph, C, Claus, C, Ferrara, C, von Hirschheydt, T, Prince, C, Funk, D, Klein, C, Benz, J. | | 登録日 | 2018-01-17 | | 公開日 | 2019-03-13 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Tumor-targeted 4-1BB agonists for combination with T cell bispecific antibodies as off-the-shelf therapy.
Sci Transl Med, 11, 2019
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7DOV
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2E7A
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2O0O
 | | Crystal structure of TL1A | | 分子名称: | MAGNESIUM ION, TNF superfamily ligand TL1A | | 著者 | Jin, T.C, Kim, S, Guo, F, Howard, A.J, Zhang, Y.Z. | | 登録日 | 2006-11-27 | | 公開日 | 2007-10-30 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | X-ray crystal structure of TNF ligand family member TL1A at 2.1A.
Biochem.Biophys.Res.Commun., 364, 2007
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2AZ5
 | | Crystal Structure of TNF-alpha with a small molecule inhibitor | | 分子名称: | 6,7-DIMETHYL-3-[(METHYL{2-[METHYL({1-[3-(TRIFLUOROMETHYL)PHENYL]-1H-INDOL-3-YL}METHYL)AMINO]ETHYL}AMINO)METHYL]-4H-CHROMEN-4-ONE, Tumor necrosis factor (TNF-alpha) (Tumor necrosis factor ligand superfamily member 2) (TNF-a) (Cachectin) [Contains: Tumor necrosis factor, membrane form; Tumor necrosis factor, ... | | 著者 | He, M.M. | | 登録日 | 2005-09-09 | | 公開日 | 2005-11-29 | | 最終更新日 | 2023-08-23 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Small-molecule inhibition of TNF-alpha.
Science, 310, 2005
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7E57
 | | Crystal structure of murine GITR-GITRL complex | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Tumor necrosis factor ligand superfamily member 18, Tumor necrosis factor receptor superfamily member 18, ... | | 著者 | Zhao, M, Tan, S, Fu, L, Chai, Y, Qi, J, Gao, G.F. | | 登録日 | 2021-02-18 | | 公開日 | 2021-09-29 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (3.302 Å) | | 主引用文献 | Atypical TNF-TNFR superfamily binding interface in the GITR-GITRL complex for T cell activation.
Cell Rep, 36, 2021
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2Q8O
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5TSW
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