3WD5

Crystal structure of TNFalpha in complex with Adalimumab Fab fragment

Summary for 3WD5

• Entry DOI: 10.2210/pdb3wd5/pdb
• Related: 4G3Y
• Descriptor: Tumor necrosis factor, Adalimumab Light Chain, Adalimumab Heavy Chain, ... (4 entities in total)
• Functional Keywords: antibody binding epitope, immune system
• Biological source: Homo sapiens (human); More
• Cellular location: Cell membrane ; Single-pass type II membrane protein . Tumor necrosis factor, membrane form: Membrane; Single-pass type II membrane protein. Tumor necrosis factor, soluble form: Secreted. C-domain 1: Secreted. C-domain 2: Secreted: P01375
• Total number of polymer chains: 3
• Total formula weight: 63935.43

Authors

Hu, S.,Liang, S.Y.,Guo, Y.J.,Lou, Z.Y. (deposition date: 2013-06-06, release date: 2013-08-14, Last modification date: 2015-07-01)

• Primary citation: Hu, S.,Liang, S.Y.,Guo, H.,Zhang, D.,Li, H.,Wang, X.,Yang, W.,Qian, W.,Hou, S.,Wang, H.,Guo, Y.J.,Lou, Z.Y.; Comparison of the inhibition mechanisms of adalimumab and infliximab in treating tumor necrosis factor alpha-associated diseases from a molecular view; J.Biol.Chem., 288:27059-27067, 2013; PubMed: 23943614; DOI: 10.1074/jbc.M113.491530

Experimental method

X-RAY DIFFRACTION (3.101 Å)