6NJ7
| 11-BETA DEHYDROGENASE ISOZYME 1 IN COMPLEX WITH COLLETOIC ACID | 分子名称: | (1S,4S,5S,9S)-9-hydroxy-8-methyl-4-(propan-2-yl)spiro[4.5]dec-7-ene-1-carboxylic acid, Corticosteroid 11-beta-dehydrogenase isozyme 1, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | 著者 | Miller, D.J, Rivas, F. | 登録日 | 2019-01-02 | 公開日 | 2019-07-24 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Mechanistic Insight on the Mode of Action of Colletoic Acid. J.Med.Chem., 62, 2019
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7JK9
| Helical filaments of plant light-dependent protochlorophyllide oxidoreductase (LPOR) bound to NADPH, Pchlide, and membrane | 分子名称: | 1,2-DISTEAROYL-MONOGALACTOSYL-DIGLYCERIDE, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, Protochlorophyllide, ... | 著者 | Nguyen, H.C, Gabruk, M, Frost, A. | 登録日 | 2020-07-28 | 公開日 | 2021-03-17 | 最終更新日 | 2021-10-06 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Photocatalytic LPOR forms helical lattices that shape membranes for chlorophyll synthesis. Nat.Plants, 7, 2021
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6UJK
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4RZH
| Crystal structure of FabG from Synechocystis sp. PCC 6803 | 分子名称: | 3-oxoacyl-[acyl-carrier protein] reductase | 著者 | Liu, Y, Xue, S. | 登録日 | 2014-12-22 | 公開日 | 2015-09-16 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Structure-directed construction of a high-performance version of the enzyme FabG from the photosynthetic microorganism Synechocystis sp. PCC 6803. Febs Lett., 589, 2015
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4WEO
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4TRR
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6USN
| Co-crystal structure of SPR with compound 5 | 分子名称: | (2-hydroxyphenyl)[3-methyl-1-(pyridin-2-yl)-1H-pyrazolo[3,4-b]pyridin-5-yl]methanone, DI(HYDROXYETHYL)ETHER, GLYCEROL, ... | 著者 | Huang, X, Wang, K. | 登録日 | 2019-10-28 | 公開日 | 2019-12-11 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.773 Å) | 主引用文献 | Virtual screening to identify potent sepiapterin reductase inhibitors. Bioorg.Med.Chem.Lett., 30, 2020
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4XGN
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5FYD
| Structural and biochemical insights into 7beta-hydroxysteroid dehydrogenase stereoselectivity | 分子名称: | GLYCEROL, OXIDOREDUCTASE, SHORT CHAIN DEHYDROGENASE/REDUCTASE FAMILY PROTEIN | 著者 | Savino, S, Ferrandi, E, Forneris, F, Rovida, S, Riva, S, Monti, D, Mattevi, A. | 登録日 | 2016-03-07 | 公開日 | 2016-04-06 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Structural and Biochemical Insights Into 7Beta-Hydroxysteroid Dehydrogenase Stereoselectivity. Proteins, 84, 2016
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5GT9
| The X-ray structure of 7beta-hydroxysteroid dehydrogenase | 分子名称: | NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, Oxidoreductase, short chain dehydrogenase/reductase family protein | 著者 | Wang, F, Wang, R, Lv, Z, Chen, Q, Huo, X. | 登録日 | 2016-08-19 | 公開日 | 2017-05-17 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Structure of NADP(+)-bound 7 beta-hydroxysteroid dehydrogenase reveals two cofactor-binding modes Acta Crystallogr F Struct Biol Commun, 73, 2017
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7ULH
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7LGB
| ChsB1 in complex with NAD+ | 分子名称: | 3-ketoacyl-ACP reductase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE | 著者 | Yuan, T, Werman, J.M, Yin, X, Yang, M, Garcia-Diaz, M, Sampson, N.S. | 登録日 | 2021-01-19 | 公開日 | 2021-04-21 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.21 Å) | 主引用文献 | Enzymatic beta-Oxidation of the Cholesterol Side Chain in Mycobacterium tuberculosis Bifurcates Stereospecifically at Hydration of 3-Oxo-cholest-4,22-dien-24-oyl-CoA. Acs Infect Dis., 7, 2021
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7LG9
| ChsB1 | 分子名称: | 3-ketoacyl-ACP reductase | 著者 | Yuan, T, Werman, J.M, Yin, X, Yang, M, Garcia-Diaz, M, Sampson, N.S. | 登録日 | 2021-01-19 | 公開日 | 2021-04-21 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.03 Å) | 主引用文献 | Enzymatic beta-Oxidation of the Cholesterol Side Chain in Mycobacterium tuberculosis Bifurcates Stereospecifically at Hydration of 3-Oxo-cholest-4,22-dien-24-oyl-CoA. Acs Infect Dis., 7, 2021
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7N09
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7X3Z
| Crystal structure of human 17beta-hydroxysteroid dehydrogenase type 1 complexed with estrone and NAD | 分子名称: | (9beta,13alpha)-3-hydroxyestra-1,3,5(10)-trien-17-one, 17-beta-hydroxysteroid dehydrogenase type 1, NICOTINAMIDE-ADENINE-DINUCLEOTIDE | 著者 | Li, T, Lin, S.X, Yin, H. | 登録日 | 2022-03-01 | 公開日 | 2023-01-25 | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | 主引用文献 | New insights into the substrate inhibition of human 17 beta-hydroxysteroid dehydrogenase type 1. J.Steroid Biochem.Mol.Biol., 228, 2023
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7X5J
| ACP-dependent oxoacyl reductase | 分子名称: | 3-oxoacyl-ACP reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, PHENYLALANINE | 著者 | Wang, S, Bai, L. | 登録日 | 2022-03-04 | 公開日 | 2023-03-08 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | ACP-dependent oxoacyl reductase To Be Published
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8CWL
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8CVN
| Cryo-EM Structure of Human 15-PGDH in Complex with Small Molecule SW209415 | 分子名称: | 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, 15-hydroxyprostaglandin dehydrogenase [NAD(+)], 2-[butyl(oxidanyl)-$l^{3}-sulfanyl]-4-(2,3-dimethylimidazol-4-yl)-6-(1,3-thiazol-2-yl)thieno[2,3-b]pyridin-3-amine | 著者 | Huang, W, Taylor, D.J. | 登録日 | 2022-05-18 | 公開日 | 2023-03-01 | 最終更新日 | 2023-03-29 | 実験手法 | ELECTRON MICROSCOPY (2.4 Å) | 主引用文献 | Small molecule inhibitors of 15-PGDH exploit a physiologic induced-fit closing system. Nat Commun, 14, 2023
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8DT1
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8FD8
| human 15-PGDH with NADH bound | 分子名称: | 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, 15-hydroxyprostaglandin dehydrogenase [NAD(+)] | 著者 | Huang, W, Taylor, D. | 登録日 | 2022-12-02 | 公開日 | 2023-03-08 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Small molecule inhibitors of 15-PGDH exploit a physiologic induced-fit closing system. Nat Commun, 14, 2023
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5LDG
| Isopiperitenone reductase from Mentha piperita in complex with Isopiperitenone and NADP | 分子名称: | (-)-Isopiperitenone, (-)-isopiperitenone reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | 著者 | Karuppiah, V, Toogood, H.S, Leys, D, Scrutton, N.S. | 登録日 | 2016-06-26 | 公開日 | 2016-08-31 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | 主引用文献 | Pinpointing a Mechanistic Switch Between Ketoreduction and "Ene" Reduction in Short-Chain Dehydrogenases/Reductases. Angew.Chem.Int.Ed.Engl., 55, 2016
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5LCX
| Isopiperitenone reductase from Mentha piperita in complex with NADP | 分子名称: | (-)-isopiperitenone reductase, (4S)-2-METHYL-2,4-PENTANEDIOL, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | 著者 | Karuppiah, V, Toogood, H.S, Leys, D, Scrutton, N.S. | 登録日 | 2016-06-22 | 公開日 | 2016-08-31 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.709 Å) | 主引用文献 | Pinpointing a Mechanistic Switch Between Ketoreduction and "Ene" Reduction in Short-Chain Dehydrogenases/Reductases. Angew.Chem.Int.Ed.Engl., 55, 2016
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6R48
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6R46
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6YC8
| Crystal structure of KRED1-Pglu enzyme | 分子名称: | 1,2-ETHANEDIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ACETATE ION, ... | 著者 | Di Pisa, F. | 登録日 | 2020-03-18 | 公開日 | 2021-02-10 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.77 Å) | 主引用文献 | Structural insights into the desymmetrization of bulky 1,2-dicarbonyls through enzymatic monoreduction. Bioorg.Chem., 108, 2021
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