PDB: 315 件ウェブページステータス検索Chemie searchBIRD

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5UND	Crystal Structure of CTCF(ZnF 4-10) With 28-mer DNA 分子名称: 1,2-ETHANEDIOL, DNA (26-MER), GLYCEROL, ... 著者 Horton, J.R, Cheng, X. 登録日 2017-01-30 公開日 2017-05-24 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.549 Å) 主引用文献 Structural Basis for the Versatile and Methylation-Dependent Binding of CTCF to DNA. Mol. Cell, 66, 2017
6VTX	Crystal structure of human KLF4 zinc finger DNA binding domain in complex with NANOG DNA 分子名称: DNA (5'-D(*AP*GP*GP*GP*GP*GP*TP*GP*TP*GP*CP*C)-3'), DNA (5'-D(*GP*GP*CP*AP*CP*AP*CP*CP*CP*CP*CP*T)-3'), Krueppel-like factor 4, ... 著者 Sharma, R, Sharma, S, Choi, K.J, Ferreon, A.C.M, Ferreon, J.C, Sankaran, B, MacKenzie, K.R, Kim, C. 登録日 2020-02-13 公開日 2021-09-01 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.14 Å) 主引用文献 Liquid condensation of reprogramming factor KLF4 with DNA provides a mechanism for chromatin organization. Nat Commun, 12, 2021
6PV3	Backbone-modified variant of zinc finger 2 from the transcription factor Sp1 DNA binding domain: altered helix, loop, turn, and sheet 分子名称: Transcription factor Sp1, ZINC ION 著者 Rao, S.R, Horne, W.S. 登録日 2019-07-19 公開日 2020-06-24 最終更新日 2023-11-15 実験手法 SOLUTION NMR 主引用文献 Proteomimetic Zinc Finger Domains with Modified Metal-binding beta-Turns. Pept Sci (Hoboken), 112, 2020
8H9H	Crystal structure of ZBTB7A in complex with GACCC-containing sequence 分子名称: DNA (5'-D(*TP*AP*AP*GP*GP*AP*CP*CP*CP*AP*GP*AP*T)-3'), DNA (5'-D(P*AP*AP*TP*CP*TP*GP*GP*GP*TP*CP*CP*TP*T)-3'), ZINC ION, ... 著者 Yang, Y. 登録日 2022-10-25 公開日 2023-04-26 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 ZBTB7A regulates primed-to-naive transition of pluripotent stem cells via recognition of the PNT-associated sequence by zinc fingers 1-2 and recognition of gamma-globin -200 gene element by zinc fingers 1-4. Febs J., 290, 2023
4X9J	EGR-1 with Doubly Methylated DNA 分子名称: DNA (5'-D(*AP*GP*(5CM)P*GP*TP*GP*GP*GP*(5CM)P*GP*T)-3'), DNA (5'-D(*TP*AP*(5CM)P*GP*CP*CP*CP*AP*(5CM)P*GP*C)-3'), Early growth response protein 1, ... 著者 White, M.A, Zandarashvili, L, Iwahara, J. 登録日 2014-12-11 公開日 2015-05-13 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.412 Å) 主引用文献 Structural impact of complete CpG methylation within target DNA on specific complex formation of the inducible transcription factor Egr-1. Febs Lett., 589, 2015
7EYI	Crystal structure of ZBTB7A in complex with gamma-globin -200 sequence element with C-194A mutation 分子名称: BORIC ACID, DNA (5'-D(*AP*TP*AP*GP*GP*GP*CP*CP*CP*CP*TP*TP*CP*CP*CP*AP*AP*C)-3'), DNA (5'-D(*TP*GP*TP*TP*GP*GP*GP*AP*AP*GP*GP*GP*GP*CP*CP*CP*TP*A)-3'), ... 著者 Yang, Y, Shi, Y.Y. 登録日 2021-05-31 公開日 2021-09-01 最終更新日 2021-10-20 実験手法 X-RAY DIFFRACTION (2.401 Å) 主引用文献 Structural basis for human ZBTB7A action at the fetal globin promoter. Cell Rep, 36, 2021
6PV1	Backbone-modified variant of zinc finger 2 from the transcription factor Sp1 DNA binding domain: Aib in the metal-binding turn 分子名称: Transcription factor Sp1, ZINC ION 著者 Rao, S.R, Horne, W.S. 登録日 2019-07-19 公開日 2020-06-24 最終更新日 2023-11-15 実験手法 SOLUTION NMR 主引用文献 Proteomimetic Zinc Finger Domains with Modified Metal-binding beta-Turns. Pept Sci (Hoboken), 112, 2020
7TXC	HIC2 zinc finger domain in complex with the DNA binding motif-2 of the BCL11A enhancer 分子名称: DNA (5'-D(*AP*CP*TP*GP*TP*TP*GP*GP*CP*AP*TP*TP*AP*TP*CP*T)-3'), DNA (5'-D(*AP*GP*AP*TP*AP*AP*TP*GP*CP*CP*AP*AP*CP*AP*GP*T)-3'), Hypermethylated in cancer 2 protein, ... 著者 Horton, J.R, Ren, R, Cheng, X. 登録日 2022-02-08 公開日 2022-06-01 最終更新日 2022-09-28 実験手法 X-RAY DIFFRACTION (3.04 Å) 主引用文献 HIC2 controls developmental hemoglobin switching by repressing BCL11A transcription. Nat.Genet., 54, 2022
6WMI	ZNF410 zinc fingers 1-5 with 17 mer blunt DNA Oligonucleotide 分子名称: 1,2-ETHANEDIOL, DNA (5'-D(*CP*AP*CP*AP*TP*CP*CP*CP*AP*TP*AP*AP*TP*AP*AP*TP*G)-3'), DNA (5'-D(*CP*AP*TP*TP*AP*TP*TP*AP*TP*GP*GP*GP*AP*TP*GP*TP*G)-3'), ... 著者 Ren, R, Horton, J.R, Cheng, X. 登録日 2020-04-21 公開日 2020-12-09 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (2.75 Å) 主引用文献 ZNF410 Uniquely Activates the NuRD Component CHD4 to Silence Fetal Hemoglobin Expression. Mol.Cell, 81, 2021
6WLH	RNA complex of WT1 zinc finger transcription factor 分子名称: RNA (29-MER), Wilms tumor protein, ZINC ION 著者 Wright, P.E, Dyson, H.J. 登録日 2020-04-20 公開日 2021-03-03 最終更新日 2024-05-01 実験手法 SOLUTION NMR 主引用文献 RNA Binding by the KTS Splice Variants of Wilms' Tumor Suppressor Protein WT1. Biochemistry, 59, 2020
4ZNF	HIGH-RESOLUTION THREE-DIMENSIONAL STRUCTURE OF A SINGLE ZINC FINGER FROM A HUMAN ENHANCER BINDING PROTEIN IN SOLUTION 分子名称: ZINC FINGER, ZINC ION 著者 Gronenborn, A.M, Clore, G.M, Omichinski, J.G. 登録日 1990-07-09 公開日 1992-01-15 最終更新日 2022-03-16 実験手法 SOLUTION NMR 主引用文献 High-resolution three-dimensional structure of a single zinc finger from a human enhancer binding protein in solution. Biochemistry, 29, 1990
6E93	Crystal Structure of ZBTB38 C-terminal Zinc Fingers 6-9 in complex with methylated DNA 分子名称: DNA (5'-D(*GP*CP*AP*CP*TP*CP*AP*TP*(DCM)P*GP*GP*(DCM)P*GP*CP*AP*GP*AP*C)-3'), DNA (5'-D(*GP*TP*CP*TP*GP*(DCM)P*GP*CP*(DCM)P*GP*AP*TP*GP*AP*GP*TP*GP*C)-3'), ZINC ION, ... 著者 Hudson, N.O, Whitby, F.G, Buck-Koehntop, B.A. 登録日 2018-07-31 公開日 2018-11-07 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (1.747 Å) 主引用文献 Structural insights into methylated DNA recognition by the C-terminal zinc fingers of the DNA reader protein ZBTB38. J. Biol. Chem., 293, 2018
6E94	Crystal Structure of ZBTB38 C-terminal Zinc Fingers 6-9 K1055R in complex with methylated DNA 分子名称: DNA (5'-D(*GP*CP*AP*CP*TP*CP*AP*TP*(DCM)P*GP*GP*(DCM)P*GP*CP*AP*GP*AP*C)-3'), DNA (5'-D(*GP*TP*CP*TP*GP*(DCM)P*GP*CP*(DCM)P*GP*AP*TP*GP*AP*GP*TP*GP*C)-3'), ZINC ION, ... 著者 Hudson, N.O, Whitby, F.G, Buck-Koehntop, B.A. 登録日 2018-07-31 公開日 2018-11-07 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (1.594 Å) 主引用文献 Structural insights into methylated DNA recognition by the C-terminal zinc fingers of the DNA reader protein ZBTB38. J. Biol. Chem., 293, 2018
5A7U	Single-particle cryo-EM of co-translational folded adr1 domain inside the E. coli ribosome exit tunnel. 分子名称: REGULATORY PROTEIN ADR1, ZINC ION 著者 Nilsson, O.B, Hedman, R, Marino, J, Wickles, S, Bischoff, L, Johansson, M, Muller-Lucks, A, Trovato, F, Puglisi, J.D, O'Brien, E, Beckmann, R, von Heijne, G. 登録日 2015-07-10 公開日 2015-09-16 最終更新日 2017-08-23 実験手法 ELECTRON MICROSCOPY (4.8 Å) 主引用文献 Cotranslational Protein Folding Inside the Ribosome Exit Tunnel. Cell Rep., 12, 2015
4M9V	Zfp57 mutant (E182Q) in complex with 5-carboxylcytosine DNA 分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, ACETATE ION, CALCIUM ION, ... 著者 Liu, Y, Olanrewaju, Y.O, Zhang, X, Cheng, X. 登録日 2013-08-15 公開日 2013-11-27 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (0.969 Å) 主引用文献 DNA recognition of 5-carboxylcytosine by a zfp57 mutant at an atomic resolution of 0.97 angstrom. Biochemistry, 52, 2013
4M9E	Structure of Klf4 zinc finger DNA binding domain in complex with methylated DNA 分子名称: ACETATE ION, DNA (5'-D(*GP*AP*GP*GP*(5CM)P*GP*TP*GP*GP*C)-3'), DNA (5'-D(*GP*CP*CP*AP*(5CM)P*GP*CP*CP*TP*C)-3'), ... 著者 Liu, Y, Olanrewaju, Y.O, Blumenthal, R.M, Zhang, X, Cheng, X. 登録日 2013-08-14 公開日 2014-02-12 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.851 Å) 主引用文献 Structural basis for Klf4 recognition of methylated DNA. Nucleic Acids Res., 42, 2014
5KL3	Wilms Tumor Protein (WT1) ZnF2-4 Q369H in complex with DNA 分子名称: 1,2-ETHANEDIOL, DNA (5'-D(*AP*GP*CP*GP*TP*GP*GP*GP*AP*GP*T)-3'), DNA (5'-D(*TP*AP*CP*TP*CP*CP*CP*AP*CP*GP*C)-3'), ... 著者 Hashimoto, H, Cheng, X. 登録日 2016-06-23 公開日 2016-09-14 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.449 Å) 主引用文献 Denys-Drash syndrome associated WT1 glutamine 369 mutants have altered sequence-preferences and altered responses to epigenetic modifications. Nucleic Acids Res., 44, 2016
5KL7	Wilms Tumor Protein (WT1) ZnF2-4Q369R in complex with carboxylated DNA 分子名称: 1,2-ETHANEDIOL, DNA (5'-D(*AP*GP*CP*GP*TP*GP*GP*GP*(1CC)P*GP*T)-3'), DNA (5'-D(*TP*AP*(5CM)P*GP*CP*CP*CP*AP*CP*GP*C)-3'), ... 著者 Hashimoto, H, Cheng, X. 登録日 2016-06-23 公開日 2016-09-14 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.579 Å) 主引用文献 Denys-Drash syndrome associated WT1 glutamine 369 mutants have altered sequence-preferences and altered responses to epigenetic modifications. Nucleic Acids Res., 44, 2016
8E3D	ZBTB7A Zinc Finger Domain Bound to DNA Duplex Containing CAST sequence (#11) 分子名称: 1,2-ETHANEDIOL, DNA (5'-D(*AP*TP*TP*TP*GP*GP*GP*GP*AP*GP*GP*GP*GP*TP*CP*TP*TP*TP*AP*AP*CP*C)-3'), DNA (5'-D(P*GP*GP*TP*AP*AP*AP*AP*GP*AP*CP*CP*CP*CP*TP*CP*CP*CP*CP*AP*AP*AP*T)-3'), ... 著者 Horton, J.R, Ren, R, Cheng, X. 登録日 2022-08-17 公開日 2023-02-08 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.62 Å) 主引用文献 Structural basis for transcription factor ZBTB7A recognition of DNA and effects of ZBTB7A somatic mutations that occur in human acute myeloid leukemia. J.Biol.Chem., 299, 2023
8E3E	ZBTB7A Zinc Finger Domain Bound to DNA Duplex Containing CAST sequence (#10) 分子名称: DNA (5'-D(*CP*TP*TP*TP*GP*GP*GP*GP*AP*GP*GP*GP*GP*TP*CP*TP*TP*TP*TP*AP*C)-3'), DNA (5'-D(*GP*GP*TP*AP*AP*AP*AP*GP*AP*CP*CP*CP*CP*TP*CP*CP*CP*CP*AP*AP*A)-3'), ZINC ION, ... 著者 Horton, J.R, Ren, R, Cheng, X. 登録日 2022-08-17 公開日 2023-02-08 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.99 Å) 主引用文献 Structural basis for transcription factor ZBTB7A recognition of DNA and effects of ZBTB7A somatic mutations that occur in human acute myeloid leukemia. J.Biol.Chem., 299, 2023
7MC3	Solution structure of Miz-1 zinc finger 12 分子名称: Isoform 2 of Zinc finger and BTB domain-containing protein 17, ZINC ION 著者 Boisvert, O, Lavigne, P. 登録日 2021-04-01 公開日 2021-04-21 最終更新日 2023-06-14 実験手法 SOLUTION NMR 主引用文献 Zinc Fingers 10 and 11 of Miz-1 undergo conformational exchange to achieve specific DNA binding. Structure, 30, 2022
7MC1	Solution structure of Miz-1 Zinc finger 10 分子名称: Isoform 2 of Zinc finger and BTB domain-containing protein 17, ZINC ION 著者 Boisvert, O, Lavigne, P. 登録日 2021-04-01 公開日 2021-04-28 最終更新日 2023-06-14 実験手法 SOLUTION NMR 主引用文献 Zinc Fingers 10 and 11 of Miz-1 undergo conformational exchange to achieve specific DNA binding. Structure, 30, 2022
7MC2	Solution structure of Miz-1 Zinc finger 11 H586Y 分子名称: Isoform 2 of Zinc finger and BTB domain-containing protein 17, ZINC ION 著者 Boisvert, O, Lavigne, P. 登録日 2021-04-01 公開日 2021-04-28 最終更新日 2023-06-14 実験手法 SOLUTION NMR 主引用文献 Zinc Fingers 10 and 11 of Miz-1 undergo conformational exchange to achieve specific DNA binding. Structure, 30, 2022
4GZN	Mouse ZFP57 zinc fingers in complex with methylated DNA 分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, ACETATE ION, CALCIUM ION, ... 著者 Liu, Y, Zhang, X, Cheng, X. 登録日 2012-09-06 公開日 2012-10-17 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (0.99 Å) 主引用文献 An atomic model of Zfp57 recognition of CpG methylation within a specific DNA sequence. Genes Dev., 26, 2012
1F2I	COCRYSTAL STRUCTURE OF SELECTED ZINC FINGER DIMER BOUND TO DNA 分子名称: 5'-D(*AP*TP*GP*GP*GP*CP*GP*CP*GP*CP*CP*CP*AP*T)-3', FUSION OF N-TERMINAL 17-MER PEPTIDE EXTENSION TO ZIF12, ZINC ION 著者 Wang, B.S, Grant, R.A, Pabo, C.O. 登録日 2000-05-25 公開日 2001-09-14 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2.35 Å) 主引用文献 Selected peptide extension contacts hydrophobic patch on neighboring zinc finger and mediates dimerization on DNA. Nat.Struct.Biol., 8, 2001

 

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