4X9J

EGR-1 with Doubly Methylated DNA

Summary for 4X9J

• Entry DOI: 10.2210/pdb4x9j/pdb
• Related: 4R2A
• Descriptor: Early growth response protein 1, DNA (5'-D(*AP*GP*(5CM)P*GP*TP*GP*GP*GP*(5CM)P*GP*T)-3'), DNA (5'-D(*TP*AP*(5CM)P*GP*CP*CP*CP*AP*(5CM)P*GP*C)-3'), ... (5 entities in total)
• Functional Keywords: dna binding, methylated dna, zinc finger, transcription, transcription regulator-dna complex, transcription regulator/dna
• Biological source: Homo sapiens (Human); More
• Cellular location: Nucleus : P18146
• Total number of polymer chains: 3
• Total formula weight: 17684.02

Authors

White, M.A.,Zandarashvili, L.,Iwahara, J. (deposition date: 2014-12-11, release date: 2015-05-13, Last modification date: 2023-09-27)

• Primary citation: Zandarashvili, L.,White, M.A.,Esadze, A.,Iwahara, J.; Structural impact of complete CpG methylation within target DNA on specific complex formation of the inducible transcription factor Egr-1.; Febs Lett., 589:1748-1753, 2015; PubMed: 25999311; DOI: 10.1016/j.febslet.2015.05.022

Experimental method

X-RAY DIFFRACTION (1.412 Å)