8WGE
 
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4TNW
 | | C. elegans glutamate-gated chloride channel (GluCl) in complex with Fab and POPC in a lipid-modulated conformation | | 分子名称: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 2-acetamido-2-deoxy-beta-D-glucopyranose, Avermectin-sensitive glutamate-gated chloride channel GluCl alpha, ... | | 著者 | Althoff, T, Hibbs, R.E, Banerjee, S, Gouaux, E. | | 登録日 | 2014-06-05 | | 公開日 | 2014-08-13 | | 最終更新日 | 2024-11-20 | | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | | 主引用文献 | X-ray structures of GluCl in apo states reveal a gating mechanism of Cys-loop receptors.
Nature, 512, 2014
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4TNV
 | | C. elegans glutamate-gated chloride channel (GluCl) in complex with Fab in a non-conducting conformation | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Avermectin-sensitive glutamate-gated chloride channel GluCl alpha, CHLORIDE ION, ... | | 著者 | Althoff, T, Hibbs, R.E, Banerjee, S, Gouaux, E. | | 登録日 | 2014-06-05 | | 公開日 | 2014-08-13 | | 最終更新日 | 2024-10-16 | | 実験手法 | X-RAY DIFFRACTION (3.6 Å) | | 主引用文献 | X-ray structures of GluCl in apo states reveal a gating mechanism of Cys-loop receptors.
Nature, 512, 2014
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8BX5
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8BXD
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8BXF
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8BXB
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8BXE
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8BYI
 | | Alvinella pompejana nicotinic acetylcholine receptor Alpo4 in complex with CHAPS(Alpo4_CHAPS) | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 3-[(3-CHOLAMIDOPROPYL)DIMETHYLAMMONIO]-1-PROPANESULFONATE, Acetylcholine receptor, ... | | 著者 | De Gieter, S, Efremov, R.G, Ulens, C. | | 登録日 | 2022-12-13 | | 公開日 | 2023-07-12 | | 最終更新日 | 2024-11-06 | | 実験手法 | ELECTRON MICROSCOPY (4.1 Å) | | 主引用文献 | Sterol derivative binding to the orthosteric site causes conformational changes in an invertebrate Cys-loop receptor.
Elife, 12, 2023
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2XYS
 | | Crystal structure of Aplysia californica AChBP in complex with strychnine | | 分子名称: | SOLUBLE ACETYLCHOLINE RECEPTOR, STRYCHNINE | | 著者 | Brams, M, Pandya, A, Kuzmin, D, van Elk, R, Krijnen, L, Yakel, J.L, Tsetlin, V, Smit, A.B, Ulens, C. | | 登録日 | 2010-11-19 | | 公開日 | 2011-03-23 | | 最終更新日 | 2024-11-13 | | 実験手法 | X-RAY DIFFRACTION (1.909 Å) | | 主引用文献 | A Structural and Mutagenic Blueprint for Molecular Recognition of Strychnine and D-Tubocurarine by Different Cys-Loop Receptors.
Plos Biol., 9, 2011
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2XYT
 | | Crystal structure of Aplysia californica AChBP in complex with d- tubocurarine | | 分子名称: | D-TUBOCURARINE, SOLUBLE ACETYLCHOLINE RECEPTOR | | 著者 | Brams, M, Pandya, A, Kuzmin, D, van Elk, R, Krijnen, L, Yakel, J.L, Tsetlin, V, Smit, A.B, Ulens, C. | | 登録日 | 2010-11-19 | | 公開日 | 2011-03-23 | | 最終更新日 | 2024-11-13 | | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | | 主引用文献 | A Structural and Mutagenic Blueprint for Molecular Recognition of Strychnine and D-Tubocurarine by Different Cys-Loop Receptors.
Plos Biol., 9, 2011
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8ZTS
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5LID
 | | X-ray structure of a pentameric ligand gated ion channel from Erwinia chrysanthemi (ELIC) in complex with bromopromazine | | 分子名称: | Cys-loop ligand-gated ion channel, bromopromazine | | 著者 | Nys, M, Wijckmans, E, Farinha, A, Brams, M, Spurny, R, Ulens, C. | | 登録日 | 2016-07-14 | | 公開日 | 2016-10-26 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (4.5 Å) | | 主引用文献 | Allosteric binding site in a Cys-loop receptor ligand-binding domain unveiled in the crystal structure of ELIC in complex with chlorpromazine.
Proc.Natl.Acad.Sci.USA, 113, 2016
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3GUA
 | | Sulfates bound in the vestibule of AChBP | | 分子名称: | SULFATE ION, Soluble acetylcholine receptor | | 著者 | Hansen, S.B, Taylor, P. | | 登録日 | 2009-03-28 | | 公開日 | 2009-07-14 | | 最終更新日 | 2024-11-06 | | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | | 主引用文献 | An Ion Selectivity Filter in the Extracellular Domain of Cys-loop Receptors Reveals Determinants for Ion Conductance
J.Biol.Chem., 283, 2008
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3RHW
 | | C. elegans glutamate-gated chloride channel (GluCl) in complex with Fab and ivermectin | | 分子名称: | (2aE,4E,5'S,6S,6'R,7S,8E,11R,13R,15S,17aR,20R,20aR,20bS)-6'-[(2S)-butan-2-yl]-20,20b-dihydroxy-5',6,8,19-tetramethyl-17 -oxo-3',4',5',6,6',10,11,14,15,17,17a,20,20a,20b-tetradecahydro-2H,7H-spiro[11,15-methanofuro[4,3,2-pq][2,6]benzodioxacy clooctadecine-13,2'-pyran]-7-yl 2,6-dideoxy-4-O-(2,6-dideoxy-3-O-methyl-alpha-L-arabino-hexopyranosyl)-3-O-methyl-alpha-L-arabino-hexopyranoside, 2-acetamido-2-deoxy-beta-D-glucopyranose, Avermectin-sensitive glutamate-gated chloride channel GluCl alpha, ... | | 著者 | Hibbs, R.E, Gouaux, E. | | 登録日 | 2011-04-12 | | 公開日 | 2011-05-25 | | 最終更新日 | 2024-11-06 | | 実験手法 | X-RAY DIFFRACTION (3.26 Å) | | 主引用文献 | Principles of activation and permeation in an anion-selective Cys-loop receptor.
Nature, 474, 2011
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3RIF
 | | C. elegans glutamate-gated chloride channel (GluCl) in complex with Fab, ivermectin and glutamate. | | 分子名称: | (2aE,4E,5'S,6S,6'R,7S,8E,11R,13R,15S,17aR,20R,20aR,20bS)-6'-[(2S)-butan-2-yl]-20,20b-dihydroxy-5',6,8,19-tetramethyl-17 -oxo-3',4',5',6,6',10,11,14,15,17,17a,20,20a,20b-tetradecahydro-2H,7H-spiro[11,15-methanofuro[4,3,2-pq][2,6]benzodioxacy clooctadecine-13,2'-pyran]-7-yl 2,6-dideoxy-4-O-(2,6-dideoxy-3-O-methyl-alpha-L-arabino-hexopyranosyl)-3-O-methyl-alpha-L-arabino-hexopyranoside, 2-acetamido-2-deoxy-beta-D-glucopyranose, Avermectin-sensitive glutamate-gated chloride channel GluCl alpha, ... | | 著者 | Hibbs, R.E, Gouaux, E. | | 登録日 | 2011-04-13 | | 公開日 | 2011-05-25 | | 最終更新日 | 2024-11-20 | | 実験手法 | X-RAY DIFFRACTION (3.345 Å) | | 主引用文献 | Principles of activation and permeation in an anion-selective Cys-loop receptor.
Nature, 474, 2011
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3RIA
 | | C. elegans glutamate-gated chloride channel (GluCl) in complex with Fab, ivermectin and iodide. | | 分子名称: | (2aE,4E,5'S,6S,6'R,7S,8E,11R,13R,15S,17aR,20R,20aR,20bS)-6'-[(2S)-butan-2-yl]-20,20b-dihydroxy-5',6,8,19-tetramethyl-17 -oxo-3',4',5',6,6',10,11,14,15,17,17a,20,20a,20b-tetradecahydro-2H,7H-spiro[11,15-methanofuro[4,3,2-pq][2,6]benzodioxacy clooctadecine-13,2'-pyran]-7-yl 2,6-dideoxy-4-O-(2,6-dideoxy-3-O-methyl-alpha-L-arabino-hexopyranosyl)-3-O-methyl-alpha-L-arabino-hexopyranoside, Avermectin-sensitive glutamate-gated chloride channel GluCl alpha, CHLORIDE ION, ... | | 著者 | Hibbs, R.E, Gouaux, E. | | 登録日 | 2011-04-13 | | 公開日 | 2011-05-25 | | 最終更新日 | 2024-11-27 | | 実験手法 | X-RAY DIFFRACTION (3.8 Å) | | 主引用文献 | Principles of activation and permeation in an anion-selective Cys-loop receptor.
Nature, 474, 2011
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3RI5
 | | C. elegans glutamate-gated chloride channel (GluCl) in complex with Fab, ivermectin and picrotoxin | | 分子名称: | (1aR,2aR,3S,6R,6aS,8aS,8bR,9R)-2a-hydroxy-8b-methyl-9-(prop-1-en-2-yl)hexahydro-3,6-methano-1,5,7-trioxacyclopenta[ij]c yclopropa[a]azulene-4,8(3H)-dione, (2aE,4E,5'S,6S,6'R,7S,8E,11R,13R,15S,17aR,20R,20aR,20bS)-6'-[(2S)-butan-2-yl]-20,20b-dihydroxy-5',6,8,19-tetramethyl-17 -oxo-3',4',5',6,6',10,11,14,15,17,17a,20,20a,20b-tetradecahydro-2H,7H-spiro[11,15-methanofuro[4,3,2-pq][2,6]benzodioxacy clooctadecine-13,2'-pyran]-7-yl 2,6-dideoxy-4-O-(2,6-dideoxy-3-O-methyl-alpha-L-arabino-hexopyranosyl)-3-O-methyl-alpha-L-arabino-hexopyranoside, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Hibbs, R.E, Gouaux, E. | | 登録日 | 2011-04-12 | | 公開日 | 2011-05-25 | | 最終更新日 | 2024-10-30 | | 実験手法 | X-RAY DIFFRACTION (3.4 Å) | | 主引用文献 | Principles of activation and permeation in an anion-selective Cys-loop receptor.
Nature, 474, 2011
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5LG3
 | | X-ray structure of a pentameric ligand gated ion channel from Erwinia chrysanthemi (ELIC) in complex with chlorpromazine | | 分子名称: | 3-(2-chloro-10H-phenothiazin-10-yl)-N,N-dimethylpropan-1-amine, Gamma-aminobutyric-acid receptor subunit beta-1 | | 著者 | Nys, M, Wijckmans, E, Farinha, A, Brams, M, Spurny, R, Ulens, C. | | 登録日 | 2016-07-05 | | 公開日 | 2016-10-26 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (3.567 Å) | | 主引用文献 | Allosteric binding site in a Cys-loop receptor ligand-binding domain unveiled in the crystal structure of ELIC in complex with chlorpromazine.
Proc.Natl.Acad.Sci.USA, 113, 2016
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8YX6
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8YX7
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8YX8
 | | Structure of a Cys-loop Receptor in Apo State | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Ligand-gated cation channel ZACN | | 著者 | Lu, X.H, Yang, X, Shen, Y.Q. | | 登録日 | 2024-04-02 | | 公開日 | 2025-01-01 | | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | | 主引用文献 | Structure of a Cys-loop Receptor in Apo State
To Be Published
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4YEU
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7KOO
 | | Alpha-7 nicotinic acetylcholine receptor bound to alpha-bungarotoxin in a resting state | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Alpha-bungarotoxin isoform V31, ... | | 著者 | Noviello, C.M, Hibbs, R.E, Gharpure, A, Mukhtasimova, N, Cabuco, R, Baxter, L, Borek, D, Sine, S. | | 登録日 | 2020-11-09 | | 公開日 | 2021-03-17 | | 最終更新日 | 2025-05-21 | | 実験手法 | ELECTRON MICROSCOPY (3 Å) | | 主引用文献 | Structure and gating mechanism of the alpha 7 nicotinic acetylcholine receptor.
Cell, 184, 2021
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7KOX
 | | Alpha-7 nicotinic acetylcholine receptor bound to epibatidine and PNU-120596 in the activated state | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | | 著者 | Noviello, C.M, Hibbs, R.E, Gharpure, A, Mukhtasimova, N, Baxter, L, Cabuco, R, Borek, D, Sine, S. | | 登録日 | 2020-11-10 | | 公開日 | 2021-03-17 | | 最終更新日 | 2025-05-14 | | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | | 主引用文献 | Structure and gating mechanism of the alpha 7 nicotinic acetylcholine receptor.
Cell, 184, 2021
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