4V1D
| Ternary complex among two human derived single chain antibody fragments and Cn2 toxin from scorpion Centruroides noxius. | Descriptor: | BETA-MAMMAL TOXIN CN2, SINGLE CHAIN ANTIBODY FRAGMENT LR, HEAVY CHAIN, ... | Authors: | Riano-Umbarila, L, Serrano-Posada, H, Rojas-Trejo, S, Rudino-Pinera, E, Becerril, B. | Deposit date: | 2014-09-25 | Release date: | 2015-10-07 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Optimal Neutralization of Centruroides Noxius Venom is Understood Through a Structural Complex between Two Antibody Fragments and the Cn2 Toxin. J.Biol.Chem., 291, 2016
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5MOU
| NMR spatial structure of scorpion alpha-like toxin BeM9 | Descriptor: | Alpha-mammal toxin BeM9 | Authors: | Mineev, K.S, Kuldushev, N.A, Berkut, A.A, Grishin, E.V, Vassilevski, A.A, Arseniev, A.S. | Deposit date: | 2016-12-14 | Release date: | 2018-01-17 | Last modified: | 2023-06-14 | Method: | SOLUTION NMR | Cite: | Refined structure of BeM9 reveals arginine hand, an overlooked structural motif in scorpion toxins affecting sodium channels. Proteins, 86, 2018
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6VXW
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2SN3
| STRUCTURE OF SCORPION TOXIN VARIANT-3 AT 1.2 ANGSTROMS RESOLUTION | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, SCORPION NEUROTOXIN (VARIANT 3) | Authors: | Zhao, B, Carson, M, Ealick, S.E, Bugg, C.E. | Deposit date: | 1992-02-20 | Release date: | 1994-01-31 | Last modified: | 2017-11-29 | Method: | X-RAY DIFFRACTION (1.2 Å) | Cite: | Structure of scorpion toxin variant-3 at 1.2 A resolution. J.Mol.Biol., 227, 1992
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4AEI
| Crystal structure of the AaHII-Fab4C1 complex | Descriptor: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ALPHA-MAMMAL TOXIN AAH2, CHLORIDE ION, ... | Authors: | Fabrichny, I.P, Mondielli, G, Conrod, S, Martin-Eauclaire, M.F, Bourne, Y, Marchot, P. | Deposit date: | 2012-01-10 | Release date: | 2012-03-07 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structural Insights Into Antibody Sequestering and Neutralizing of Na+-Channel & [Alpha]-Type Modulator from Old-World Scorpion Venom J.Biol.Chem., 287, 2012
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6THI
| Solution structure of MeuNaTxalpha-1 toxin from Mesobuthus Eupeus | Descriptor: | Sodium channel neurotoxin MeuNaTxalpha-1 | Authors: | Mineev, K.S, Kuzmenkov, A.I, Khusainov, G.A, Arseniev, A.S, Vassilevski, A.A. | Deposit date: | 2019-11-20 | Release date: | 2020-12-02 | Last modified: | 2023-06-14 | Method: | SOLUTION NMR | Cite: | Structure of MeuNaTx alpha-1 toxin from scorpion venom highlights the importance of the nest motif. Proteins, 2021
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5CY0
| Total Chemical Synthesis, Covalent Structure Verification, and X-ray Structure of Bioactive Ts3 Toxin by Racemic Protein Crystallography | Descriptor: | GLYCEROL, Ts3 Toxin | Authors: | Dang, B, Kubota, T, Mandal, K, Correa, A.M, Bezanilla, F, Kent, S.B. | Deposit date: | 2015-07-29 | Release date: | 2016-06-01 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.93 Å) | Cite: | Elucidation of the Covalent and Tertiary Structures of Biologically Active Ts3 Toxin. Angew.Chem.Int.Ed.Engl., 55, 2016
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8BO0
| Solution structure of Lqq4 toxin from Leiurus quinquestriatus quinquestriatus | Descriptor: | Alpha-toxin Lqq4 | Authors: | Mineev, K.S, Motov, V.V, Vassilevski, A.A, Chernykh, M.A, Kuzmenkov, A.I. | Deposit date: | 2022-11-14 | Release date: | 2023-09-20 | Last modified: | 2023-10-04 | Method: | SOLUTION NMR | Cite: | A scorpion toxin affecting sodium channels shows double cis-trans isomerism. Febs Lett., 597, 2023
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4KYP
| Beta-Scorpion Toxin folded in the periplasm of E.coli | Descriptor: | Beta-insect excitatory toxin Bj-xtrIT, TETRAETHYLENE GLYCOL, TRIETHYLENE GLYCOL | Authors: | O'Reilly, A.O, Cole, A.R, Lopes, J.L, Lampert, A, Wallace, B.A. | Deposit date: | 2013-05-29 | Release date: | 2014-02-12 | Last modified: | 2018-01-24 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Chaperone-mediated native folding of a beta-scorpion toxin in the periplasm of Escherichia coli. Biochim.Biophys.Acta, 1840, 2014
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4HHF
| Crystal Structure of chemically synthesized scorpion alpha-toxin OD1 | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, Alpha-toxin OD1 | Authors: | Wang, C.I.A, Lewis, R.J, Alewood, P.F, Durek, T. | Deposit date: | 2012-10-09 | Release date: | 2013-04-24 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Chemical engineering and structural and pharmacological characterization of the alpha-scorpion toxin OD1. Acs Chem.Biol., 8, 2013
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2KBH
| solution structure of BmKalphaTx11 (major conformation) | Descriptor: | Toxin Bmka2 | Authors: | Zhu, J, Wu, H. | Deposit date: | 2008-11-28 | Release date: | 2009-12-08 | Last modified: | 2019-12-11 | Method: | SOLUTION NMR | Cite: | Solution structure of BmKalphaTx11, a toxin from the venom of the Chinese scorpion Buthus martensii Karsch Biochem.Biophys.Res.Commun., 391, 2010
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2LKB
| Evolutionary diversification of Mesobuthus alpha-scorpion toxins affecting sodium channels | Descriptor: | Neurotoxin MeuNaTx-5 | Authors: | Zhu, S, Peigneur, S, Gao, B, Lu, X, Cao, C, Tytgat, J. | Deposit date: | 2011-10-09 | Release date: | 2011-11-02 | Last modified: | 2023-06-14 | Method: | SOLUTION NMR | Cite: | Evolutionary diversification of Mesobuthus {alpha}-scorpion toxins affecting sodium channels Mol.Cell Proteomics, 2011
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2LJM
| Solution Structure of CssII | Descriptor: | Beta-mammal toxin Css2 | Authors: | del Rio-Portilla, F, Saucedo, A.L, Corzo, G, Delepierre, M, Possani, L.D. | Deposit date: | 2011-09-20 | Release date: | 2012-02-15 | Method: | SOLUTION NMR | Cite: | Solution structure of native and recombinant expressed toxin CssII from the venom of the scorpion Centruroides suffusus suffusus, and their effects on Nav1.5 Sodium channels. Biochim.Biophys.Acta, 1824, 2012
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2LI7
| Solution Structure of CssII | Descriptor: | Beta-mammal toxin Css2 | Authors: | del Rio-Portilla, F, Saucedo, A.L, Corzo, G, Delepierre, M, Possani, L.D. | Deposit date: | 2011-08-24 | Release date: | 2012-02-15 | Method: | SOLUTION NMR | Cite: | Solution structure of native and recombinant expressed toxin CssII from the venom of the scorpion Centruroides suffusus suffusus, and their effects on Nav1.5 Sodium channels. Biochim.Biophys.Acta, 1824, 2012
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1ZVG
| Crystal Structure Of Mutant K8DP9S Of Scorpion alpha-Like Neurotoxin Bmk M1 From Buthus Martensii Karsch | Descriptor: | Alpha-like neurotoxin BmK-I | Authors: | Ye, X, Bosmans, F, Li, C, Zhang, Y, Wang, D.C, Tytgat, J. | Deposit date: | 2005-06-02 | Release date: | 2006-06-20 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.2 Å) | Cite: | Structural basis for the voltage-gated Na+ channel selectivity of the scorpion alpha-like toxin BmK M1 J.Mol.Biol., 353, 2005
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2A7T
| Crystal Structure of a novel neurotoxin from Buthus tamalus at 2.2A resolution. | Descriptor: | Neurotoxin | Authors: | Ethayathulla, A.S, Sharma, M, Saravanan, K, Sharma, S, Kaur, P, Yadav, S, Srinivasan, A, Singh, T.P. | Deposit date: | 2005-07-06 | Release date: | 2005-07-19 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Crystal structure of a highly acidic neurotoxin from scorpion Buthus tamulus at 2.2A resolution reveals novel structural features. J.Struct.Biol., 155, 2006
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2ATB
| Triple mutant 8D9D10V of scorpion toxin LQH-alpha-IT | Descriptor: | 1,2-ETHANEDIOL, CHLORIDE ION, NITRATE ION, ... | Authors: | Kahn, R, Karbat, I, Gurevitz, M, Frolow, F. | Deposit date: | 2005-08-24 | Release date: | 2006-09-05 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | X-ray structures of Lqh-alpha-IT and Lqh-alpha-IT8D9D10V mutant To be Published
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2YEO
| A39L mutation of scorpion toxin lqh-alpha-it | Descriptor: | 1,2-ETHANEDIOL, ALPHA-INSECT TOXIN LQHAIT, CHLORIDE ION, ... | Authors: | Frolow, F, Kahn, R, Gurevitz, M. | Deposit date: | 2011-03-28 | Release date: | 2011-04-13 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.08 Å) | Cite: | Crystal Structures of Scorpion Alpha-Toxinsmutants Reveal Conformational Constraints that Dictate Preference for Mammalian Brain Voltage-Gated Na- Channels To be Published
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2YC1
| Crystal structure of the human derived single chain antibody fragment (scFv) 9004G in complex with Cn2 toxin from the scorpion Centruroides noxius Hoffmann | Descriptor: | BETA-MAMMAL TOXIN CN2, GLYCEROL, SINGLE CHAIN ANTIBODY FRAGMENT 9004G | Authors: | Canul-Tec, J.C, Riano-Umbarila, L, Rudino-Pinera, E, Becerril, B, Possani, L.D, Torres-Larios, A. | Deposit date: | 2011-03-10 | Release date: | 2011-04-13 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structural Basis of Neutralization of the Major Toxic Component from the Scorpion Centruroides Noxius Hoffmann by a Human-Derived Single Chain Antibody Fragment. J.Biol.Chem., 286, 2011
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2YBR
| Crystal structure of the human derived single chain antibody fragment (scFv) 9004G in complex with Cn2 toxin from the scorpion Centruroides noxius Hoffmann | Descriptor: | BETA-MAMMAL TOXIN CN2, SINGLE CHAIN ANTIBODY FRAGMENT 9004G | Authors: | Canul-Tec, J.C, Riano-Umbarila, L, Rudino-Pinera, E, Becerril, B, Possani, L.D, Torres-Larios, A. | Deposit date: | 2011-03-09 | Release date: | 2011-04-13 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.55 Å) | Cite: | Structural Basis of Neutralization of the Major Toxic Component from the Scorpion Centruroides Noxius Hoffmann by a Human-Derived Single Chain Antibody Fragment J.Biol.Chem., 286, 2011
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2E0H
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2ASC
| Scorpion toxin LQH-alpha-IT | Descriptor: | 1,2-ETHANEDIOL, CHLORIDE ION, ETHANOL, ... | Authors: | Kahn, R, Karbat, I, Gurevitz, M, Frolow, F. | Deposit date: | 2005-08-23 | Release date: | 2006-09-05 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.1 Å) | Cite: | X-ray structures of Lqh-alpha-IT and Lqh-alpha-IT8D9D10V mutant To be Published
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2B3C
| SOLUTION STRUCTURE OF A BETA-NEUROTOXIN FROM THE NEW WORLD SCORPION CENTRUROIDES SCULPTURATUS EWING | Descriptor: | PROTEIN (NEUROTOXIN CSE-I) | Authors: | Jablonsky, M.J, Jackson, P.L, Trent, J.O, Watt, D.D, Krishna, N.R. | Deposit date: | 1998-12-09 | Release date: | 1998-12-16 | Last modified: | 2023-12-27 | Method: | SOLUTION NMR | Cite: | Solution structure of a beta-neurotoxin from the New World scorpion Centruroides sculpturatus Ewing. Biochem.Biophys.Res.Commun., 254, 1999
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2I61
| Depressant anti-insect neurotoxin, LqhIT2 from Leiurus quinquestriatus hebraeus | Descriptor: | 1,2-ETHANEDIOL, ACETIC ACID, CARBON DIOXIDE, ... | Authors: | Frolow, F, Gurevitz, M, Karbat, I, Turkov, M, Gordon, D. | Deposit date: | 2006-08-27 | Release date: | 2006-12-26 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.2 Å) | Cite: | X-ray Structure and Mutagenesis of the Scorpion Depressant Toxin LqhIT2 Reveals Key Determinants Crucial for Activity and Anti-Insect Selectivity. J.Mol.Biol., 366, 2007
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2KBJ
| solution structure of BmKalphaTx11 (minor conformation) | Descriptor: | Toxin Bmka2 | Authors: | Zhu, J, Wu, H. | Deposit date: | 2008-11-28 | Release date: | 2009-12-08 | Last modified: | 2022-03-16 | Method: | SOLUTION NMR | Cite: | Solution structure of BmKalphaTx11, a toxin from the venom of the Chinese scorpion Buthus martensii Karsch Biochem.Biophys.Res.Commun., 391, 2010
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