4HHF
Crystal Structure of chemically synthesized scorpion alpha-toxin OD1
Summary for 4HHF
Entry DOI | 10.2210/pdb4hhf/pdb |
Descriptor | Alpha-toxin OD1, (4S)-2-METHYL-2,4-PENTANEDIOL (3 entities in total) |
Functional Keywords | scorpion long-chain alpha-toxin, gating modulator, voltage-gated sodium channels 1.4, 1.6, 1.7, inhibition of fast channel inactivation, c-terminally amidated, venom gland, toxin |
Biological source | Odontobuthus doriae (Yellow Iranian scorpion) |
Cellular location | Secreted: P84646 |
Total number of polymer chains | 1 |
Total formula weight | 7575.71 |
Authors | Wang, C.I.A.,Lewis, R.J.,Alewood, P.F.,Durek, T. (deposition date: 2012-10-09, release date: 2013-04-24, Last modification date: 2023-09-20) |
Primary citation | Durek, T.,Vetter, I.,Wang, C.I.,Motin, L.,Knapp, O.,Adams, D.J.,Lewis, R.J.,Alewood, P.F. Chemical engineering and structural and pharmacological characterization of the alpha-scorpion toxin OD1. Acs Chem.Biol., 8:1215-1222, 2013 Cited by PubMed: 23527544DOI: 10.1021/cb400012k PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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