4V1D

Ternary complex among two human derived single chain antibody fragments and Cn2 toxin from scorpion Centruroides noxius.

Summary for 4V1D

Entry DOI	10.2210/pdb4v1d/pdb
Descriptor	SINGLE CHAIN ANTIBODY FRAGMENT LR, HEAVY CHAIN, SINGLE CHAIN ANTIBODY FRAGMENT LR, LIGHT CHAIN, BETA-MAMMAL TOXIN CN2, ... (6 entities in total)
Functional Keywords	toxin-immune system complex, human scfv, scorpion venom neutralization, directed evolution, cn2 toxin., toxin/immune system
Biological source	HOMO SAPIENS (HUMAN) More
Cellular location	Secreted: 4V1D
Total number of polymer chains	5
Total formula weight	64315.96
Authors	Riano-Umbarila, L.,Serrano-Posada, H.,Rojas-Trejo, S.,Rudino-Pinera, E.,Becerril, B. (deposition date: 2014-09-25, release date: 2015-10-07, Last modification date: 2024-01-10)
Primary citation	Riano-Umbarila, L.,Ledezma-Candanoza, L.M.,Serrano-Posada, H.,Fernandez-Taboada, G.,Olamendi-Portugal, T.,Rojas-Trejo, S.,Gomez-Ramirez, I.V.,Rudino-Pinera, E.,Possani, L.D.,Becerril, B. Optimal Neutralization of Centruroides Noxius Venom is Understood Through a Structural Complex between Two Antibody Fragments and the Cn2 Toxin. J.Biol.Chem., 291:1619-, 2016 Cited by PubMed: 26589800 DOI: 10.1074/JBC.M115.685297 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.1 Å)

Structure validation