8T60

CryoEM structure of an inward-facing MelBSt at a Na(+)-bound and sugar low-affinity conformation

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005886	cellular_component	plasma membrane
A	0015293	molecular_function	symporter activity
A	0055085	biological_process	transmembrane transport
A	0071702	biological_process	organic substance transport

Functional Information from PROSITE/UniProt

site_id	PS00872
Number of Residues	26
Details	NA_GALACTOSIDE_SYMP Sodium:galactoside symporter family signature. DpimGwivNatrsrw..GKFKPWILiGT

Chain	Residue	Details
A	ASP59-THR84

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site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YICNVNH

Chain	Residue	Details
L	TYR192-HIS198
H	TYR194-HIS200

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	274
Details	TRANSMEM: Helical => ECO:0000269|PubMed:34341464, ECO:0007744|PDB:7L16, ECO:0007744|PDB:7L17

Chain	Residue	Details
A	LYS8-MET30
A	ALA324-VAL349
A	ILE367-ILE394
A	GLY409-ARG431
A	GLY42-VAL66
A	LYS77-ALA97
A	GLN105-SER129
A	LEU144-VAL167
A	GLY178-ASN200
A	LEU233-ILE255
A	LEU267-LEU289
A	ILE297-LEU318

---

site_id	SWS_FT_FI2
Number of Residues	52
Details	TOPO_DOM: Periplasmic => ECO:0000269|PubMed:34341464, ECO:0007744|PDB:7L16, ECO:0007744|PDB:7L17

Chain	Residue	Details
A	TYR31-VAL41
A	HIS98-ALA104
A	SER168-PHE177
A	TYR256-ASP266
A	ALA319-ASN323
A	GLY395-GLN408

---

site_id	SWS_FT_FI3
Number of Residues	119
Details	TOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:34341464, ECO:0007744|PDB:7L16, ECO:0007744|PDB:7L17

Chain	Residue	Details
A	ASN67-PHE76
A	LEU130-GLN143
A	VAL201-GLN232
A	VAL290-ARG296
A	ALA350-SER366
A	TYR432-ALA476

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269|PubMed:34341464, ECO:0007744|PDB:7L17

Chain	Residue	Details
A	LYS18
A	ASP124
A	TRP128
A	ARG149

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