8DYE
Crystal structure of human SDHA-SDHAF4 assembly intermediate
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000104 | molecular_function | succinate dehydrogenase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005730 | cellular_component | nucleolus |
| A | 0005739 | cellular_component | mitochondrion |
| A | 0005743 | cellular_component | mitochondrial inner membrane |
| A | 0005749 | cellular_component | mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone) |
| A | 0005759 | cellular_component | mitochondrial matrix |
| A | 0006099 | biological_process | tricarboxylic acid cycle |
| A | 0006105 | biological_process | succinate metabolic process |
| A | 0006121 | biological_process | mitochondrial electron transport, succinate to ubiquinone |
| A | 0007399 | biological_process | nervous system development |
| A | 0008177 | molecular_function | succinate dehydrogenase (quinone) activity |
| A | 0009055 | molecular_function | electron transfer activity |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016627 | molecular_function | oxidoreductase activity, acting on the CH-CH group of donors |
| A | 0022900 | biological_process | electron transport chain |
| A | 0022904 | biological_process | respiratory electron transport chain |
| A | 0042776 | biological_process | proton motive force-driven mitochondrial ATP synthesis |
| A | 0045257 | cellular_component | succinate dehydrogenase complex (ubiquinone) |
| A | 0050660 | molecular_function | flavin adenine dinucleotide binding |
| B | 0005975 | biological_process | carbohydrate metabolic process |
| B | 0016853 | molecular_function | isomerase activity |
Functional Information from PROSITE/UniProt
| site_id | PS00504 |
| Number of Residues | 10 |
| Details | FRD_SDH_FAD_BINDING Fumarate reductase / succinate dehydrogenase FAD-binding site. RSHTvaAqGG |
| Chain | Residue | Details |
| A | ARG97-GLY106 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | ACT_SITE: Proton acceptor => ECO:0000250|UniProtKB:Q9YHT1 |
| Chain | Residue | Details |
| A | ARG340 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 9 |
| Details | BINDING: BINDING => ECO:0000250|UniProtKB:Q0QF01 |
| Chain | Residue | Details |
| A | GLY68 | |
| A | THR91 | |
| A | ASP275 | |
| A | HIS296 | |
| A | THR308 | |
| A | HIS407 | |
| A | GLU440 | |
| A | ARG451 | |
| A | SER456 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | MOD_RES: Tele-8alpha-FAD histidine => ECO:0000250|UniProtKB:Q0QF01 |
| Chain | Residue | Details |
| A | HIS99 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 9 |
| Details | MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:Q8K2B3 |
| Chain | Residue | Details |
| A | LYS167 | |
| A | LYS182 | |
| A | LYS480 | |
| A | LYS517 | |
| A | LYS550 | |
| A | LYS598 | |
| A | LYS624 | |
| A | LYS636 | |
| A | LYS647 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 7 |
| Details | MOD_RES: N6-succinyllysine; alternate => ECO:0000250|UniProtKB:Q8K2B3 |
| Chain | Residue | Details |
| A | LYS179 | |
| A | LYS250 | |
| A | LYS335 | |
| A | LYS485 | |
| A | LYS498 | |
| A | LYS538 | |
| A | LYS547 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphotyrosine; by SRC => ECO:0000269|PubMed:22823520 |
| Chain | Residue | Details |
| A | TYR215 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | MOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861 |
| Chain | Residue | Details |
| A | LYS541 | |
| A | LYS608 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 1 |
| Details | MOD_RES: N6-succinyllysine => ECO:0000250|UniProtKB:Q8K2B3 |
| Chain | Residue | Details |
| A | LYS615 |
